Research works

Evaluating the Cost-Effectiveness of Interlinked Fire Alarm Systems in Scotland and England

Abstract This paper applies the J value framework to assess when interlinked domestic fire alarm systems would be cost effective in Scotland and England. Pre policy national statistics pool dwellings with no alarms, standalone alarms (the vast majority), and some interlinked syst...

When habit prevails: a causal test of policy feedback theory using a pension reform

Abstract Elderly voters are a growing, politically powerful electoral bloc, and their pensions often constitute the largest component of welfare state. We know that cuts can provoke electoral backlash, but it is less clear whether benefit expansions mobilize retirees. Some policy...

Tier 2 racial disparities in reading: An illustration of exploring opportunities and outcomes

Abstract Important questions exist about the extent to which racial gaps exist in instructional opportunities and achievement outcomes for elementary students in schools implementing multi-tiered systems of support. In the United States, concerns about gaps for Black and White st...

Gut virome instability in HSCT

The gut virome remains one of the least resolved components of the human microbiome, limiting interpretation of how viral communities shape intestinal injury and recovery. Hematopoietic stem cell transplantation (HSCT), particularly in the allogeneic setting, offers an informativ...

Multimodal imaging diagnosis of concurrent left pulmonary arterial hypoplasia and right pulmonary arterial stenosis in a cat

A 10-month-old intact male British Shorthair cat weighing 4.1 kg was referred for evaluation of suspected heart disease, characterized by open-mouth respiration after physical activity. On physical examination, a grade 4/6 bilateral systolic murmur was auscultated. Thoracic radio...

Fertility support needs of reproductive-age women based on the Kano model and ERG theory: a cross-sectional study

Amidst the declining fertility rate and population aging, providing effective fertility supports for reproductive-age women is urgently needed. Hence, understanding their fertility support needs is paramount. An observational design was implemented and the STROBE Checklist was ad...

Laparoscopic versus open appendectomy for appendicitis in children: a systematic review and meta-analysis

Acute appendicitis is among the most common pediatric surgical emergencies worldwide. Laparoscopic appendectomy (LA) has gained wide acceptance in recent years ; however, its superiority over the traditional open appendectomy (OA) is still a topic of debate, particularly regardin...

Interactive effects of warming, nutrient enrichment, and substrate type on zooplankton communities associated with submerged macrophyte

Abstract Warming and eutrophication can alter the structure of aquatic communities. In shallow lakes, zooplankton associated with submerged macrophytes exhibit high species richness and play a key role in maintaining clear-water conditions and enhancing water quality. However, th...

Glycemic risk stratification in older adults with heart failure: the prognostic role of HbA1c in an aging society

Glycated haemoglobin (HbA1c) is central to diabetes mellitus (DM) management, but its prognostic value in older adults, aged ≥80 years, with heart failure (HF) remains uncertain. Thus, the study aimed to evaluate the association between HbA1c levels and all-cause mortality among...

Behavior change support in the new era of obesity care

Evidence of the effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to improve cardiometabolic health has increased rapidly, as has patient and public demand. This has, and continues to, reshape clinical practice and public health priorities. The World Health O...

A review of synthetic strategies for macrocyclic bifunctional chelators in molecular imaging and radiopharmaceutical applications

Metal complexes play indispensable roles in modern medicine, underpinning diagnostic techniques such as magnetic resonance imaging and nuclear imaging, as well as targeted radionuclide therapy. Their clinical success relies on chelators that form thermodynamically stable and kine...

Problematic Smartphone Use in Parkinson’s Disease: Associations with Mood, Non-Motor Burden, and Impulsivity

Objective: To investigate problematic smartphone use and its associations with mood symptoms, impulsivity, and non-motor symptom burden in Parkinson's disease (PD). Methods: Forty-five patients with PD younger than 60 years and 43 matched healthy controls completed the Smartphone...

Understanding responses to domestic violence and abuse among older adults: a systematic review and meta-synthesis of stakeholder perspectives

Domestic violence and abuse (DVA) among older adults is an increasingly recognized public health and human rights concern with significant physical, psychological, and social consequences. This systematic review and meta-synthesis aimed to synthesize qualitative evidence on respo...

Engineered nanocomplex for targeted delivery of Beclin1 peptide enables autophagy-mediated tumor suppression and immune activation

Although autophagy is a central regulator of cellular homeostasis, its potential to reprogram the immunosuppressive tumor microenvironment (TME) remains largely unexplored. Within the TME, the dysregulated deposition of Tenascin-C (TNC) establishes a formidable extracellular matr...

E3 Ubiquitin Ligases in MASH ‐Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities

Metabolic dysfunction-associated steatohepatitis (MASH) is a major cause of progressive liver fibrosis and can ultimately lead to cirrhosis and hepatocellular carcinoma (HCC). MASH-associated liver fibrosis develops through a complex interplay among lipotoxic hepatocyte injury, o...

Deletion of protein tyrosine phosphatase 1B in hepatocytes attenuates inflammation, steatosis, and fibrosis in a dietary mouse model of metabolic dysfunction-associated steatohepatitis

Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver-related morbidity and mortality. The current interventions are limited, underscoring the need for novel mechanism-based therapies. Protein tyrosine phosphatase 1B (PTP1B) regul...

Series approximations of the polylogarithm with applications to Euler sums and certain integrals

Abstract A series approximation of the polylogarithm based on values of the Riemann zeta function is proposed, and truncation of this series yields finite approximations of the polylogarithm. Both the series representation and its truncated versions of the series are applied to c...

Latent profiles and influencing factors of missed nursing care among ICU nurses

Abstract Background Missed nursing care (MNC) is common in intensive care units (ICUs) and seriously threatens patient safety. Most existing studies treat ICU nurses as a homogeneous group, overlooking within-group heterogeneity. Based on the Job Demands-Resources model, this stu...

Silicon Use Efficiency and Response in Sugarcane Genotypes Under Greenhouse Conditions

Abstract Given the wide genetic variability of sugarcane ( Saccharum spp.) and the importance of silicon (Si) for this crop, this study aimed to assess the response of 50 genotypes to Si supply under greenhouse conditions, screening for genotypes with contrasting efficiency and r...

Risk factors for external apical root resorption in orthodontics: the role of treatment modalities and tooth-related conditions

External apical root resorption (EARR) is a multifactorial and often irreversible complication observed during orthopaedic and fixed appliance treatment. This study aimed to identify possible risk factors for orthodontically induced EARR and to determine whether there is an incre...