Research works

APOS-SRR approach: a result of the networking of theories between APOS Theory and semiotic representation registers

Abstract The objective of this research was to formally articulate Action, Process, Object, and Schema (APOS) Theory and Semiotic Representation Registers (SRR) Theory through the Networking of Theories methodology. As a result, we propose an approach denominated APOS-SRR, an exp...

Single‐Atom and Subnanocluster Platforms for Next‐Generation Clinical Practice: A Bench‐to‐Bedside Approach

ABSTRACT Single‐atom and subnanocluster platforms are at the cutting edge of translational sensing technologies for future clinical use. Their dispersion at the atomic level ensures optimal metal utilization, clearly defined active sites, and precise control over electronic struc...

Efficient Hydrogen Evolution Enabled by a Noble‐Metal‐Free NiTiCu Thin‐Film Metallic Glass Electrocatalyst

Hydrogen is a promising green alternative to fossil fuels. However, the scarcity and high cost of platinum group metals pose a major economic challenge to the large‐scale production of hydrogen. To address this issue, we investigated a novel, noble‐metal‐free NiTiCu thin‐film met...

Antimicrobial Efficacy of Plasma-Activated Water Against Enterococcus faecalis Biofilms: An In Vitro and Ex Vivo Study

Abstract This study evaluated the antimicrobial efficacy of plasma-activated water (PAW) against Enterococcus faecalis biofilms using in vitro and ex vivo tooth models. E. faecalis biofilms were cultivated in 96-well plates and exposed to PAW with activated times of 2, 4, 6, 8, 1...

Governance Adaptation Time (GAT): A Qualitative Reconstruction Protocol for Temporal Fit under AI Conditions

This research note develops Governance Adaptation Time (GAT) as a qualitative event-response reconstruction protocol for examining temporal fit under AI conditions. GAT is scenario-specific and is not presented as a metric, score, KPI or benchmark. Its proposed constructs and pro...

E8-Phi Resonance-Preserving Quantum Trajectories for Continuous-Time Meta-Stability — E8 Intelligence Research

By encoding Hamiltonian loop invariants into the E8 cyclic root vectors' phi-scaled harmonic potentials, we derive geodesic particle trajectories that maintain coherence through deterministic bifurcation points aligned with the 240-fold spin forest symmetry — enabling continuous-...

Behavioural Friction Theory: Toward a Common Currency for Behavioural Science

Behavioural science has produced robust findings across dozens of research traditions, yet lacks the integrative architecture needed to connect them — a common unit or map for relating constructs across domains and anticipating cross-field interactions. Behavioural Friction Theor...

Current smoking and COPD are associated with differentiation-dependent secretory and inflammatory programs in airway basal cells

Abstract Background Persistent airway epithelial abnormalities contribute to chronic obstructive pulmonary disease (COPD), but it remains unclear whether smoking- and COPD-associated epithelial remodeling is retained in airway basal cells and transmitted during differentiation. W...

The Processing Twin

This paper investigates whether mine-to-mill recommendations remain technically defensible when laboratory evidence, feed identity, process measurements, instrument calibration and mass-water-metal accounting refer to the same controlled operating period. The Processing Twin test...

Identification of the Novel HLA‐B*57:212 Allele by Next‐Generation Sequencing

HLA-B*57:212 differs from HLA-B*57:01:01:01 by a single nucleotide substitution in exon 5.

Digital transformation capabilities and innovation performance in skating manufacturing: a hybrid SEM–ANN analysis

Digital upgrading in specialized manufacturing sectors is associated with firms’ development of flexible IT infrastructure, agile response capability, system integration, and strategic digital vision. However, limited empirical modelling has examined how these digital manufacturi...

Dual-task performance after primary and revision total knee arthroplasty: Comparison of mobility and dynamic balance

This study aimed to compare functional mobility and dynamic balance under single-task and dual-task conditions in patients after primary total knee arthroplasty (TKA) and revision TKA, and to examine dual-task cost as an indicator of motor performance deterioration under cognitiv...

High frequency of antibiotic resistance in organisms isolated from blood cultures among pediatric patients in a public hospital with limited resources in the northern Dominican Republic

Abstract Background Bloodstream infections (BSIs) are a significant cause of morbidity and mortality in pediatric patients. The World Health Organization (WHO) estimates that three million children develop sepsis each year, with mortality rates between 11% and 19%. In Latin Ameri...

The Probability Changes With the Model: What Density Estimation Actually Believes

Probability models are often described as if they reveal how likely observations truly are. In practice, a density is conditional on a representation, model family, complexity, bandwidth, covariance rule, reference population, and measure. Even the numerical value of a continuous...

REGULATORY CONSIDERATIONS FOR ADVANCED THERAPY MEDICINAL PRODUCTS (ATMPS): GLOBAL PERSPECTIVES

Advanced Therapy Medicinal Products (ATMPs), including gene therapy medicinal products, somatic cell therapy medicinal products, tissue-engineered products, and certain combined advanced therapies, represent a major transformation in modern medicine. Unlike conventional small-mol...

Holographic Dark Energy Models with a Hybrid Bounce in General Relativity

AbstractIn this paper, we investigate four distinct Holographic Dark Energy (HDE) models; Rényi HDE, Tsallis HDE, Sharma–Mittal HDE, and Barrow HDEin the framework of standard General Relativity with a spatially flat Friedmann–Robertson–Walker (FRW) metric, admitting a novel Hybr...

Unencumbered Virtual Reality: Sensory Reconstruction, Interocular Delay, and Opt-In Neural Tailoring

We specify virtual reality for a standing observer with no headset and no glasses. Head-mounted displays, including stereoscopic glasses, are not required by the visual system: the optical image terminates at the retina and is reconstructed as spike patterns. Interocular delay is...

Synergistic mechanism of virtual reality and reinforcement learning in educational adaptive learning systems

This paper proposes a VR (Virtual Reality) and RL (Reinforcement Learning) collaborative optimization model based on the TD3 (Twin Delayed Deep Deterministic Policy Gradient) algorithm to address the ineffective integration of immersive interactive data and intelligent decision-m...

Lattice Dynamics Coupled at an Interface

A coupled lattice dynamical system generated by two infinite lattice differential equations meeting asymptotically at an interface is studied. This can be interpreted as a special case of dynamics on graphs with the sum of inputs and outputs at each node satisfying the Kirchhoff...

Spatium Mutans: Event‐Level Chronotopic Alignments and Moral Deontic Stance in Mobile Interviews With Border‐Crossing Facilitators

ABSTRACT This article examines how two border‐crossing facilitators construct moral legitimacy across four recorded journey segments—two outbound and two return—between Italy and Austria. Mobility provides the organizing condition: journey direction, passenger copresence, and the...