Research works

Multi-level poultry disease detection from fecal images using jellyfish search honey badger optimization and deep learning in IoT frameworks

Poultry is a major source of food, and growing demand for animal-based products has driven agricultural industries to increase production. However, this expansion has also led to a significant rise in the spread of infectious diseases. Several limitations faced by conventional me...

ARTIFICIAL INTELLIGENCE IN DRUG REPURPOSING FOR PARKINSON'S DISEASES: A COMPREHENSIVE REVIEW

Parkinson’s disease (PD), the second most common neurodegenerative disorder, remains a major challenge in drug discovery due to its complex pathophysiology involving α-synuclein aggregation, oxidative stress, mitochondrial dysfunction, and neuroinflammation. Conventional drug dev...

Anomalous hardening of CrMnFeCoNi high-entropy alloy deformed by high-pressure torsion

Abstract The CrMnFeCoNi high-entropy alloy (HEA) was severely deformed by high-pressure torsion (HPT) at temperatures ranging from 77 K to 673 K. Phase stability, microstructure and texture were investigated by diffraction of synchrotron radiation. At low HPT temperatures, the lo...

Constraint Preservation and Multi-Stage Refinement: An Agent Optimization Framework for Literary Writing

The bottleneck of Large Language Models in creative writing lies not in generation, but in goal-directed optimization — improving literary quality while adhering to formal constraints. We propose the first agent optimization framework to explicitly separate hard constraints (form...

Extracellular vesicle proteins monitor and interfere with CLDN18.2-targeted CAR-T cell and antibody therapies against gastrointestinal cancers

Abstract Claudin 18.2 (CLDN18.2)-targeted CAR-T cell and antibody therapies show promise against gastrointestinal cancers, but biomarkers predictive of long-term benefit and therapeutic sensitization strategies are needed. Here we show that proteins carried by circulating extrace...

Prospective outcomes of adults with speciated Mycobacterium avium complex lung disease, 2021-2026

Abstract Rationale Mycobacterium avium complex lung disease (MAC-LD) is clinically heterogeneous and carries diverse outcomes. Objectives To describe predictors of clinical progression of MAC-LD in a state-wide cohort. Methods We enrolled adults with MAC-LD from across Virginia,...

Cardiac Manifestations Following Suspected Cobra ( Naja samarensis ) Bites in Eastern Visayas, Philippines: A Case Series

Naja samarensis , a World Health Organization Category 1 venomous snake endemic to the Philippines, causes neurotoxic envenomation, but cardiac complications are rarely documented. Case 1 is a 71-y-old hypertensive male who presented with altered consciousness, ptosis, and dysart...

Innate limitations and deprivation of liberty

Richard Griffith , Senior Lecturer in Health Law at Swansea University, discusses limitations that restrict the right to liberty, potentially exposing the vulnerable to disproportionate restrictions and undignified care

Proportional Autoregressive Quasi-Lindley Half-Logistic Unit Process with Application in Modeling Crime Dynamics

The manuscript proposes a novel bounded proportional autoregressive (PAR) process based on the quasi-Lindley half-logistic unit (QHU) distribution, termed the QHU-PAR(1) process. Fundamental probabilistic properties of the process are established, including its Markov structure,...

Dietary Supplementation with Multispecies Probiotic Fermented Broth Improves Nutrient Digestibility and Carcass Traits While Modulating the Cecal Microbiota and Thigh Muscle Fatty Acid Profile in Yellow-Feathered Broilers

This study evaluated the effects of dietary supplementation with 4% multispecies probiotic fermented broth (MPFB) on the apparent nutrient digestibility, carcass traits, serum immune indices, intestinal morphology, cecal microbiota, and thigh muscle nutrient composition in 815-st...

Evaluation of Disease Severity Using CSF Biomarkers in Patients With Probable Cerebral Amyloid Angiopathy

Cerebral amyloid angiopathy (CAA) is currently diagnosed using MRI-based Boston criteria. However, imaging markers represent downstream consequences of vascular injury and may not fully reflect disease severity. CSF biomarkers, particularly β-amyloid 1–42 (Aβ42) and β-amyloid 1–4...

CT-Derived Body Composition and Early Changes Predict Outcomes of First-Line Chemo-Immunotherapy in Recurrent/Metastatic Nasopharyngeal Carcinoma

Abstract Background Reliable biomarkers for risk stratification and treatment monitoring in recurrent/metastatic nasopharyngeal carcinoma (R/M NPC) treated with first-line chemo-immunotherapy remain limited. This study evaluated the prognostic value of baseline computed tomograph...

Intervention Design for Individual Behavior Change in Stroke Prevention Trials

Stroke prevention requires that patients follow recommended health behaviors. However, few stroke behavioral interventions have been shown to produce clinically significant behavior change in clinical trials, likely thwarted in the design process by limited application of behavio...

Pangu's Cosmic Axe and its earthly counterpart

The paper suggests that a bronze axe from the Xia dynasty, preserved at the Shanghai Museum, may represent the mythological axe with which Pangu breaks the cosmic egg to create Heaven and Earth.

Zungung-P: an Open Narrative Engine exploring the possibilities of genre flexibility and hard worldbuilding.

ZUNGUNG-P: An Open Narrative Engine Exploring the Possibilities of Genre Flexibility and Hard Worldbuilding. Zungung-P is a worldbuilding project set within the fantasy and low-fantasy genre, aimed at exploring the capabilities of hard worldbuilding, meant to showcase a propriate...

Low-Carbon Valorization of Waste PE Mulch Film: A Carbon Footprint Comparative Analysis of Typical End-of-Life Treatment Pathways

Widespread polyethylene (PE) mulch film application has caused severe farmland plastic pollution and greenhouse gas emissions. To identify low-carbon end-of-life pathways for waste agricultural mulch film, this study established a full life-cycle carbon footprint model comparing...

The TBT agreement and food labelling: Indonesia’s mandatory health warnings in the WTO-specific trade concern mechanism

Purpose This study aims to analyse World Trade Organisation (WTO) specific trade concerns (STCs) raised against Indonesia’s Ministry of Health Regulation No. 30 of 2013 (MoH Regulation No. 30/2013), which mandates sugar, salt and fat (SSF) content disclosure and health warnings o...

Efficacy and Safety of Stent-Assisted Coiling Versus Coiling Alone for Ruptured Multilobed Aneurysms: A Multicenter Study

BACKGROUND: Ruptured multilobed intracranial aneurysms present significant procedural challenges and high recurrence risks in endovascular treatment due to complex geometry and turbulent hemodynamics. Currently, the safety and long-term efficacy of stent-assisted coiling (SAC) ve...

Green practices in academic libraries: validating a survey to measure sustainability awareness and perceptions

Purpose This study investigates academic librarians' awareness of and attitudes toward green library practices, technologies and theoretical frameworks. It aims to develop and validate a survey instrument capable of measuring these constructs among academic library employees acro...

E8-Phi Torsional Mode Locking Enables Scalable Topological Qubit Arrays — E8 Intelligence Research

By projecting the 240 E8 root vectors onto phi-scaled torsion folds and driving the system at the 132 Hz base frequency, a set of phase‑locked topological solitons emerges in the manifold. These solitons inherit the E8 symmetry and act as intrinsically protected qubit states, whe...