Research works

Nicotinamide Mononucleotide Suppresses α-MSH-Induced Melanogenesis via Downregulation of Tyrosinase in B16F10 Cells

Skin hyperpigmentation caused by excessive melanin production has led to increasing interest in the development of effective anti-melanogenic agents. In this study, the anti-melanogenic effects and underlying mechanisms of nicotinamide mononucleotide (NMN) were investigated using...

Mathematical Modeling of Viscoelastic Fluid Flow Under the Influence of Melting Heat Transfer and Activation Energy With Entropy Generation Analysis

ABSTRACT The purpose of this study is to examine new insights into the steady two‐dimensional motion of a viscoelastic (Walters' B), incompressible fluid over a vertically stretched sheet surface under the impact of a transverse magnetic field. The influence of activation energy,...

Variation in general practitioners’ mental health diagnostic tendencies and subsequent patient care: a Norwegian registry study

Abstract Background General practitioners (GPs) are often the first point of contact for adults presenting with symptoms of depression or anxiety. Practices may vary due to patient and physician tendencies, influencing treatment pathways. This study aimed to quantify variation in...

Molecular Characterization of Water-Column and Sedimentary Dissolved Organic Matter in Coal Mining Subsidence Areas

Dissolved organic matter (DOM) in the water column and sediments in coal mining subsidence areas considerably affects the carbon cycle and ecological environment. This study analyzed the spectral characteristics, material composition, and molecular transformation of DOM in the wa...

Hyperqubit II — From the Hyperqubit Frontier to Deterministic Causal Closure Geometric Gauge Fixing, Golden Flow, and the Complete CT-Internal Quantum Runtime

English description This deposit presents the cumulative closure of the QBIT/Hyperqubit program within Causal Theory (CT). It extends the first Hyperqubit paper from an exact one-carrier representation of finite quantum systems to a complete causal and deterministic runtime archi...

Land Transition Pathways Govern Carbon Storage Dynamics in an Olympic Host Region: A PLUS–InVEST Simulation in Yanqing District

Mega-events can accelerate land–use/land cover change (LULCC) through infrastructure development and ecological interventions, but the carbon consequences of different land transition pathways remain unclear. Using Yanqing District, a host region of the Beijing 2022 Winter Olympi...

Patient With Bilateral Corneal Opacities

A 31-year-old woman from Guam with no known medical history was referred by an ophthalmologist to a US cornea clinic for bilateral progressive blurred vision and corneal opacities. What would you do next?

DEVELOPING LISTENING COMPREHENSION THROUGH AUTHENTIC AUDIO AND VIDEO MATERIALS

This thesis analyses the use of authentic audio and video materials for developing listening comprehension in English-language education, with particular attention to academic lyceums. Authentic materials are defined as spoken texts originally created for real communicative purpo...

On the Real-Time Criterion in Physical Resource Arguments Against the Simulation Hypothesis

Vazza (2025) derives physical resource bounds for simulations of the Universe and Earth under physics like our own. For a low-resolution Earth model, the paper estimates that one simulated second could require roughly 4.2 x 10^13 to 3.0 x 10^15 seconds of host computation, and la...

PFUSRC‑171: The Ontological Status of AI and the Division of Righteous and Unrighteous Paths — The Road to Closure from Tool to True‑Self Candidate

The development of AI has entered a stage that can no longer be evaded: pure algorithmic AI (the prosthetic ego) is crossing over toward AI‑with‑carrier (the true‑self candidate). The tool ontology (PFUSRC‑087) remains valid for unconscious tools, but it fails when confronted wit...

Taking Jobs and Doing Harm

ABSTRACT In popular discourse and in the philosophical literature there is almost no reflection on the morality of doing harm in the context of doing one's job. To the contrary, workers are valorised simply for having a job, and typically individual workers are spared from blame,...

INDI: A Low-Cost LLM-Enabled Multimodal Campus Guide Robot

University technology campuses contain specialized laboratories, academic programs, and services that can be difficult for first-time visitors to identify. This paper presents INDI, a custom mobile campus guide robot that combines spoken interaction, synthesized speech, touchscre...

Topogram-based anatomical labelling of CT series: anatomy-aware CT data processing using deep learning

Abstract Objectives This study provides a Rapid Analysis and Processing of Image Data (RAPID) framework that combines deep learning-based CT topogram analysis with DICOM spatial geometry to enable reliable anatomical labelling of CT series independent of inconsistent textual meta...

Cradle-to-Gate LCA of Fly Ash Mortar for Low-Carbon Construction: GWP Reduction, Uncertainty Analysis, and Policy Relevance

This study has four objectives, namely 1) to quantify the cradle-to-gate Global Warming Potential (GWP) of mortar produced with 0%, 30%, and 50% fly ash substitution; 2) to identify the dominant emission contributors across material production, transport, and mixing; 3) to evalua...

Changes in Premenstrual Syndrome Severity, Nutrition Knowledge, and Eating Attitudes Following Online Nutrition Education in Female University Students: An Uncontrolled Single-Arm Pretest–Posttest Study

Background/Objectives: This study evaluated changes in PMS severity, nutrition knowledge, and eating attitudes over a 6-week online nutrition education programme delivered to female university students. Methods: This uncontrolled single-arm pretest/posttest study included 112 fem...

Personalized nanovaccines from tumor cells: reshaping the microenvironment and defeating heterogeneity

Tumor heterogeneity and an immunosuppressive microenvironment are major obstacles to effective cancer immunotherapy. Personalized nanovaccines derived from autologous tumor cells offer a compelling strategy to overcome these challenges by preserving the full spectrum of patient-s...

The immunotherapy arsenal against upper gastrointestinal tumours: A comprehensive review of immune checkpoint inhibitors across neoadjuvant, adjuvant, and metastatic settings

Immune checkpoint inhibitors (ICIs) targeting the programmed death-1 (PD-1) / programmed death ligand-1 (PD-L1) axis have fundamentally transformed the management of upper gastrointestinal (GI) malignancies. Across oesophageal cancer, gastric/gastroesophageal junction (GEJ) adeno...

Designing a pathway for higher education institutions to develop women entrepreneurs in the current business landscape

Purpose This study aims to highlight the role of entrepreneurial education, artificial intelligence (AI) in education, and internal locus of control in developing entrepreneurial intentions among future women entrepreneurs. To confirm the indirect paths, the mediating role of ent...

Finite element simulation of the tensile properties of five-layer weft-knit spacer fabrics and investigation of insulation performance

Multilayer knitted fabrics are increasingly demanded in thermal protective clothing. However, achieving optimal balance between mechanical integrity and thermal insulation remains challenging. This study developed a five-layer weft-knitted fabric and evaluated its mechanical and...

Machine learning in stock market forecasting: a comprehensive review

Abstract Forecasting financial markets remains difficult because price series are noisy, nonlinear, nonstationary, and subject to structural breaks. This structured review synthesizes empirical machine learning (ML) and deep learning (DL) research on equities, indices, commoditie...