Research works

Pediatric effects of forever chemicals may last for a long time

Abstract Perfluorinated alkylate substances (PFASs) have been in use for about 75 years. Because of their persistence, concentrations in the environment have increased, and absorbed PFAS will remain in the human body, some compounds for many years. The fetus and the newborn infan...

Exogenous Carbohydrate Metabolism Under Energy Deficit and Environmental Stress

Physiological stress of environmental exposure and energy deficit impairs the absorption, transport, and utilization of exogenous carbohydrate for fuel during exercise. Blunted exogenous carbohydrate oxidation may require alternative fueling strategies to optimize carbohydrate me...

Standardized Spark-Pattern Cut-Mode Electrosurgical Bailout Workflow for Difficult Left Bundle Branch Area Pacing Lead Advancement: Procedural and Follow-Up Outcomes From a 15-Patient Case Series

BACKGROUND: Electrosurgical facilitation can aid difficult left bundle branch area pacing lead advancement, but standardized delivery patterns, reassessment logic, and follow-up lead performance remain insufficiently defined. METHODS: We retrospectively analyzed 15 consecutive pa...

Intensive care infection score outperforms inflammatory biomarkers in detecting infection in critically ill patients

Identification of infection in critically ill patients remains challenging, as conventional biomarkers such as C-reactive protein (CRP), procalcitonin (PCT) and white blood cell count (WBC) frequently lack diagnostic accuracy. The Intensive Care Infection Score (ICIS), a host-res...

Alterations in diacylglycerol kinase θ define early pathological features of Alzheimer's disease in a mouse model

Background Diacylglycerol kinase theta (DGKθ) is an enzyme involved in lipid signaling pathways and has been implicated in Alzheimer's disease (AD). DGKθ plays a crucial role in regulating diacylglycerol and phosphatidic acid levels, which are important for neuronal function and...

Genetics and germination of the endangered bog bird's-foot trefoil (Hosackia pinnata; Fabaceae) in Canada

Hosackia pinnata (bog bird’s-foot trefoil) is an endangered legume in Canada that is restricted to Vancouver Island, British Columbia, but populations exist in western U.S.A. We provide the first status update for this species in Canada since 2003 and the first evaluation of gene...

Reclassifying No Specific Molecular Profile Endometrial Cancer: A Narrative Review of Molecular Heterogeneity, Prognostic Refinement, and Clinical Management

Molecular classification has transformed the management of endometrial cancer (EC), yet the no specific molecular profile (NSMP) subtype remains a major challenge for precision oncology due to its substantial biological and clinical heterogeneity. This narrative review summarizes...

Vibration response of a waterjet propulsion pump under low-gas-fraction microbubble inflow

This study experimentally investigates the vibration attenuation effect of low-inlet-gas-volume-fraction microbubble inflow in a waterjet propulsion pump. Hydraulic performance and triaxial vibration responses at the inlet, impeller, and outlet were measured under IGVF values of...

A pH-Responsive Charge-Reversal Nanoplatform for Combined Chemophotothermal Therapy of Oral Cancer

Abstract The global incidence of oral cancer has risen rapidly at progressively younger ages due to the impact of unhealthy lifestyle habits. Therefore, there is an urgent need to develop novel oral cancer treatments. Combination therapy with chemotherapy and photothermal therapy...

Analytical study on the vibration of spatial plate-plate coupled structures with combined simply supported and clamped edges

Spatial plate-plate coupled structures (cross, L, and T-shaped) are fundamental elements in engineering, yet a unified solution covering multiple coupling configurations, arbitrary coupling angles, and combined simply supported-clamped boundaries remains unavailable. This study d...

Aligning clean energy innovations with the SDGs: sectoral dynamics of green bonds and sustainability-enhanced equities across market conditions

This study examines the dynamic interconnections among clean energy innovations, green bonds, and sectoral sustainability-enhanced equities, and their implications for advancing SDGs 7, 9, 11, 12, and 13. Using a Quantile VAR model and daily data from 31 October 2016–27 December...

Self-medication as metaphor: why psychiatry should revise an (in) convenient narrative about substance use and mental disorders

Summary The term self-medication remains an influential narrative to explain why some patients with mental health problems use psychoactive substances. This Feature offers a conceptual critique of its broad use in psychiatry. We argue that self-medication often functions less as...

Wealth-Driven Bubbles in Speculative Markets

Abstract We develop a behavioral model that generates wealth-driven bubbles in speculative asset markets whose fundamental value is zero. These dynamics arise from a feedback loop between asset prices and speculators’ wealth: rising prices increase their wealth, leading them to d...

Association between meteorological variables and diabetic ketoacidosis admissions: a single-center observational study

Abstract Background Evidence on hot weather and acute diabetes complications comes mainly from temperate, high-income countries; hot semi-arid regions and children are underrepresented. We examined emergency department admissions for diabetic ketoacidosis (DKA) in relation to met...

Humanized anti-BAMBI monoclonal antibody as a novel therapeutic strategy for psoriatic arthritis

Psoriasis (PsO) is a chronic autoimmune skin disease that affects 2% of the global population, with 30% of patients progressing to psoriatic arthritis (PsA). Both conditions are primarily mediated by CD4 + T cells, whose differentiation into distinct subpopulations depends on the...

How Many Crystal Structures Do You Need to Trust Your Docking Results?

Abstract Structure-based drug discovery relies on the prediction of protein-bound poses of new molecule designs, the accuracy of which can impact downstream prioritization. While it is expected that crystal structures of similar molecules would provide the best template for predi...

Interfacial pH Dynamics in Lattice-Nitrogen Protonation to Ammonia

Abstract We recently discovered a new class of nitride MXenes (MNenes) that undergo lattice-nitrogen protonation to form ammonia under cathodic potentials. Unexpectedly, neutral electrolytes outperform both acidic and alkaline media, revealing the critical role of the interfacial...

Underpricing and Overachievement: Celebrating Jay Ritter's IPO Research

ABSTRACT This tribute celebrates Jay Ritter's scholarship on the occasion of his election as Fellow of the American Finance Association. Best known for documenting and IPO underpricing, hot issue markets, and the long‐run underperformance of new issues, Jay has shaped how academi...

Capitalizing consumer school ratings into residential listing prices: evidence from Greater Houston

Purpose This paper aims to estimate how much of a consumer-facing school rating is capitalized into the price at which a home is offered for sale and to test whether that rating displaces the official state accountability score in a large metropolitan market that has received lit...

Lysosomal Expansion Compartments Mediate Zinc and Copper Homeostasis in Caenorhabditis elegans

Abstract Zinc is an essential transition metal that participates in many biological processes. In C. elegans, excess zinc is stored in lysosomes in intestinal cells; this process involves increasing the expression of the zinc transporter CDF-2 and remodeling of lysosomes characte...