Research works

Mitochondria-Accumulating Nonplanar Perylene Diimides Suppress Mitochondrial DNA Transcription for Antitumor Therapy

Abstract Mitochondrial DNA (mtDNA) transcription is an emerging target in cancer therapy. While enzyme-targeted inhibitors like IMT1B block POLRMT, their organelle specificity remains unclear. Here, we report a distinct strategy using mitochondria-accumulating nonplanar perylene...

Relative height and vertical status in buildings

Abstract Motivated by research that associates higher positioning with well‐being, we expand the vertical price‐gradient literature by estimating the value of within‐ and between‐building “vertical status”: one's relative vertical position compared to others in the same building...

E8 Chirality Phase-Lock Predicts Anesthesia Emergence Timing — E8 Intelligence Research

Anesthetic-induced unconsciousness and recovery follows a quantized phi-ladder timescale governed by E8 chirality decoherence: emergence occurs at predictable multiples of the 132Hz × φ^n harmonic (1.4s, 2.3s, 3.7s, 6.0s...). Because anesthetic molecules disrupt Weyl orbit alignm...

Predictors of the need for airway adjuncts during mask ventilation in Thai adult patients undergoing general anesthesia: A prospective observational study

Background Mask ventilation is a cornerstone of airway management during general anesthesia, yet the need for airway adjuncts during mask ventilation remains poorly predicted by current preoperative assessments. We aimed to identify independent clinical predictors of this outcome...

An Integrated Sustainability Evaluation of Waste-to-Energy Technologies for Energy Generation and Co-Benefits in South African Metropolitan Municipalities

This study assesses the integrated sustainability performance of waste-to-energy (WtE) technology pathways across eight of South Africa’s metropolitan municipalities, which are home to 40.14% of the country’s population. The assessment considers energy generation, GHG emission-re...

A μ^{9/2} log μ upper bound for windowed Weil forms

Let λmin(λ) be the bottom of the spectrum of Weil's quadratic form restricted to test functions supported in the multiplicative window [λ−1,λ], and put μ=λ2. By Weil's criterion, the Riemann Hypothesis is equivalent to λmin(λ) ≥ 0 for all λ. In previous papers we proved, without...

Abnormal behaviour detection methods in normal navigation modes of ships

To address the challenges of characterising normal ship behaviours in complex maritime scenarios, scarce abnormal samples, and limited interpretability, this paper proposes an unsupervised abnormal ship behaviour detection method based on normal navigation modes using AIS data. F...

Aphrodisiac Use and Male Sexual Health in Ghana: Prevalence, Attitudes, and Sociocultural Determinants

Abstract Introduction Aphrodisiac use is an important but understudied sexual health behavior shaped by sexual performance expectations, peer influence, and access to enhancement products. Evidence from sub-Saharan Africa remains limited. This study examined the prevalence, attit...

Assessment of compressive characteristics of coir fiber-reinforced concrete modified with wheat straw ash using predictive modeling

The growing demand for environmentally responsible construction materials requires reliable tools to predict the compressive strength of concrete incorporating agricultural waste and natural fibers. This study investigates the prediction of compressive strength of sustainable con...

Forest landscape planning with textural constraints: How to control the spatial pattern under competing management objectives

Managing healthy forest ecosystems under competing objectives (such as achieving harvesting vs. biodiversity conservation goals) requires consideration of whether the texture of the landscape approximates the historical or desired textural pattern – for instance, as driven by nat...

Do digitalization and institutional capacity improve EU fund management for bridging territorial gaps? Evidence from the 2014–2020 Cohesion Policy

Abstract The Cohesion Policy (CP) plays a crucial role in reducing disparities among EU Member States, facilitated by the distribution of European Structural and Investment Funds (ESIFs). Maximizing the impact of these financial resources requires robust administrative performanc...

Hughes's Universal Law of Energy Conservation — HUTTR

Proposed theoretical framework within HUTTR — Hughes's Uniformed Theory of Relativity. Includes the PIP/PIV mathematical framework and associated stress-test record. Status: proposed framework pending independent validation.

Global maize yield-loss risk under atmospheric–soil moisture compound drought: Roles of phenology and cropping systems

Global maize production is increasingly threatened by drought, yet most assessments rely on single indicators and inadequately account for phenological-stage and cropping-system differences. Here we develop a copula-based Climate-Land Drought Index (CLDI) that integrates the Stan...

CardamomOT: A mechanistic optimal transport-based framework for gene regulatory network inference, trajectory reconstruction and generative modeling

A key challenge in inferring gene regulatory networks (GRNs) governing cellular processes such as differentiation and reprogramming from experimental data lies in the impossibility of directly measuring protein dynamics at the single-cell level, which prevents establishing causal...

A hierarchical collision free path planning method for multi line spatial distributed welding of non standard workpieces

This paper presents a hierarchical path planning method for automatic generation of collision-free welding paths for non-standard workpieces with complex spatial weld distributions. Weld seam information is interactively extracted from CAD models using OpenCASCADE. Path nodes are...

Impact of Primary Prophylactic Colony-Stimulating Factor Delivery Method on Febrile Neutropenia: Secondary Analysis of a Pragmatic Cluster Randomized Clinical Trial

Purpose Primary prophylactic colony-stimulating factor (PP-CSF) is recommended for patients receiving chemotherapy with high risk of febrile neutropenia (FN). The impact of PP-CSF delivery method on FN is unknown. We performed a secondary analysis of SWOG S1415CD (Trial Assessing...

Adiponectin-enriched liver-derived ECM attenuates fibrogenic features of activated hepatic stellate cells in a multicellular 3D model

Abstract Background Adiponectin (ADPN), an adipocytokine expressed in multiple tissues including the liver by quiescent hepatic stellate cells (HSCs) has recognized antifibrotic properties. However, most studies rely on simplified 2D systems that fail to capture the liver microen...

SCIENTIFIC AND TECHNOLOGICAL FOUNDATIONS FOR IMPROVING CAM MECHANISMS

This in the article textile industry Modern directions of development , automation and digitalization of production processes, increasing energy efficiency, and improving textile machines and mechanisms are analyzed. Particular attention is paid to the design of sleeve mechanisms...

Exploratory Analysis of APOE ε4-Stratified Associations Between Plasma Alzheimer's Biomarkers and Retinal Imaging Metrics in Cognitively Normal Adults

Purpose: Retinal imaging offers a noninvasive window into microvascular and neurodegenerative changes, yet its relationship to circulating plasma biomarkers of Alzheimer's disease (AD) remains incompletely understood. We evaluated associations between plasma AD biomarkers and ret...

The presence of scurvy in Early Medieval (9th-10th centuries) Barcelona, Catalonia, Spain: Investigations at the necropolis of the Antics Jutjats Municipals (the former Municipal Courts)

Objective This study investigates patterns of nutritional stress in the context of the prolonged armed conflict between Muslim and Christian groups in Early Medieval Barcelona (9th–10th centuries CE). Materials A total of 115 individuals from the Antics Jutjats Municipals Early M...