Research works

A holistic QMRA tool to assess current and future health risks from the drinking water production process

ABSTRACT Climate and socioeconomic changes have the potential to impact waterborne pathogens and associated health risks, although the extent of these impacts remains uncertain. Quantitative microbial risk assessment (QMRA) is a widely used method for estimating health risks from...

Mean arterial pressure for children in US emergency department and prehospital settings

Objectives To externally validate previously reported centile curves for the mean arterial pressure (MAP) on paediatric acute care samples; derive centile curves for paediatric MAP in an acute care population and evaluate the association of age-adjusted MAP with prehospital and i...

When is a rigid pelvis–trunk approximation sufficient? An output-specific model-reduction protocol applied to lumbar mobility in multibody biomechanics

This final manuscript revision presents an output-specific computational model-reduction protocol for lumbar mobility in multibody biomechanics. The primary study compares mass-equivalent exact-lock, axial-yaw-only and three-coordinate architectures using ModelicaHumanBodyPArts v...

Reduced Detection of Human Orphan Gene Transcripts in Disease Tissue Relative to Expression- and Detection- Matched Controls

Human orphan genes are poorly annotated and lowly expressed, which makes their behavior in disease difficult to establish. We analyzed paired normal and disease RNA-seq libraries from four cohorts, quantified against a combined reference in which 2190 of 198,507 transcripts are o...

SARIMA-based forecasting of mangrove vegetation indices across India

Abstract Mangrove ecosystems are crucial to the ecological and climatic dynamics of the Asia–Pacific coastline. However, the ability to predict long-term changes is limited, hindering evidence-based resilience and adaptation strategies. The study presents a remote-sensing framewo...

Sartans and Bisartans: Expanding Therapeutic Horizons Through Broad Receptor Interactions and Repurposing Potential

Angiotensin receptor blockers (ARBs), also known as sartans, are a family of highly selective angiotensin II type 1 receptor antagonists commonly prescribed to individuals with hypertension, heart failure, and chronic kidney disease. Additionally, the discovery and facile synthes...

Ascending inputs to inferior colliculus subdivisions reveal pathway-specific hybrid organization in the external cortex

The inferior colliculus (IC) is a hub of the auditory system, integrating ascending inputs from auditory and non-auditory brainstem nuclei before relaying information to the thalamus and the cortex. The IC is classically divided into the central nucleus (CIC) and surrounding shel...

Assessment of the Drainage Network Systems and Their Effects on Stormwater Flow and Flooding in Orogun, Ughelli North, Delta State, Nigeria

Flooding has become a recurring environmental challenge in many Nigerian urban centers, with Orogun town in Ughelli North Local Government Area of Delta State experiencing increasing vulnerability to stormwater inundation. This study assesses the drainage network and its effects...

Nuclear-Wavefunction Geometric Phase Verified by Variable Separation for a 96D + 2D Molecule–Surface Model with Nozzle and Surface Parameters

Abstract It has been well-known that the geometric phase of the electronic wavefunction is due to separation of electrons and nuclei. The associated geometric phase effects were considered in quantum molecular dynamics by adding a vector potential, called the Berry connection, in...

Components of family empowerment for family caregivers of older adults with dementia: focus group interviews

Abstract Background Strengthening empowerment plays a pivotal role in supporting family caregivers of older adults with dementia. This study explored the comprehensive caregiving experiences of both family caregivers and dementia care professionals to identify and describe the co...

Palfree Squares in a Two-Parameter Family of Near-Repdigits

For integers \(1 \le d \le 9\), \(0 \le e \le 9\), and \(n \ge 1\), let\[N_{d,e}(n)=d\frac{10^n-1}{9}+(e-d).\]For \(n \ge 2\), this is the decimal integer consisting of \(n-1\) copies of \(d\) followed by \(e\). We classify exactly when \(N_{d,e}(n)^2\) is palfree, meaning that i...

Phi-E8 Temporal Lattice for Quantum Coherence — E8 Intelligence Research

By assigning each of the 240 E8 root vectors a phase angle proportional to the golden ratio (φ) of the 132 Hz base frequency, a self‑synchronizing temporal lattice emerges that aligns qubit error cycles with geometric invariants. This lattice maps error trajectories onto the root...

A Comment on Timothy Bowers Vasko, Making All the World America: Native Information and the Doctrine of Discovery (University of Pennsylvania Press, 2026)

Peter d'Errico comments on Timothy Bowers Vasko's Making All the World America: Native Information and the Doctrine of Discovery (University of Pennsylvania Press, 2026), as a companion to Steven T. Newcomb's review of the same book. Working from the publisher's description, d'Er...

Adeno‐associated virus ‐mediated restoration of Na V 1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of Na V 1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures,...

Key considerations for window of opportunity trials and preoperative endocrine therapy in breast cancer

Window of opportunity (WOO) trials are short, pre-surgical trials which aim to evaluate novel therapeutic strategies and answer biological and mechanistic questions. Despite their relative simplicity, their conduct can be challenging. This Perspectives Article considers key facto...

Poly(propylene carbonate- co -thioether- co -ether) Terpolymer and Its Application as a Solid-State Electrolyte

Abstract Sulfur-containing polymers, especially those with sulfur in the main chain, have attracted significant interest owing to their diverse structures and unique properties, making them promising candidates for solid-state electrolytes. However, their controllable synthesis i...

Exploring EFL learners’ vocabulary learning in a longitudinal mobile-assisted context

Abstract Mobile-assisted vocabulary learning (MAVL) provides flexible, multimodal support for EFL vocabulary development, yet its effectiveness heavily depends on learners’ self-directed learning (SDL). Prior research has rarely examined learners’ longitudinal vocabulary learning...

Four Closing Theorems: Anomaly, Generations, Gravity, and the Continuum Limit (Withdrawn as Proof)

Version 2.0 withdraws all four theorems of this paper as proofs, following the external referee audit of 6 October 2026 (prepared for Prof. Pablo Moscato, University of Newcastle; one automated reviewer). Theorem 60.1: the paper computes {T, Γ5} = 4iI exactly and then states that...

Impact of PD-1 and PD-L1 inhibitors on patient-reported outcomes in esophageal squamous cell carcinoma: a systematic review of clinical trials

OBJECTIVES: Esophageal squamous cell carcinoma (ESCC) carries a poor prognosis and is associated with symptoms such as dysphagia that substantially impair patients' health-related quality of life (HRQoL). The combination of chemotherapy with an immune checkpoint inhibitor is wide...

Measurements and Analysis of Light Non‐Methane Hydrocarbon Mole Fractions in 1982–1987 at Six Remote Sites Along the Pacific Rim

Abstract Atmospheric non‐methane hydrocarbons (NMHCs) are important trace species with anthropogenic and natural sources including fugitive emissions from fossil fuel mining and distribution, biomass burning, biofuel combustion, and biogenic emissions from microbes and plants. We...