Research works

Titin gene mutation is related to refractory acute lymphoblastic leukemia in children

This study aimed to elucidate the association of Titin ( TTN ) gene mutations with refractory pediatric acute lymphoblastic leukemia (ALL). This investigation, included 152 pediatric patients with ALL who were treated in Guangdong Provincial People’s Hospital between 2019 and 202...

No External-Field Effect: Cluster-Satellite Lensing, the Cassini Quadrupole and the Outer Solar System Point to an EFE-Blind MOND Sector

Version 1.0 (AI-assisted research programme; not peer reviewed). We test the quadrature MOND law g^2 = g_N^2 + a0 g_N (a0 = (1/2) c sqrt(G rho_Lambda)) against three data sets sensitive to the external-field effect (EFE). Weak lensing of cluster satellites (Sifon et al. 2018, fiv...

Piezo1 Activation by Yoda1 Inhibits Mechanosensitive ATP Release in Human Urothelial Cells and Bladder Overactivity in Rats with Bladder Outlet Obstruction

Urothelial ATP release during bladder filling modulates afferent nerve activity and detrusor contractility to regulate the micturition reflex, yet the upstream mechanosensory mechanism linking distension to ATP release remains unclear. Here we investigated the role of Piezo1 in r...

Parental Stigma and “Good Parenting” in Child and Adolescent Mental Health

OBJECTIVE: Parents of children with mental health problems often experience judgment about their parenting. Such stigma is associated with lower parental well-being and greater child symptom severity. Theory-driven descriptions of and interventions for parental stigma are limited...

Purification performance of coconut fibers, palm kernel fibers, and shredded plastic bottles in biofilter septic tanks: efficiency and limitations

ABSTRACT This biofiltration system tests three substrates: plastic fragments (COD: -55%, turbidity: -95%, nitrates: -60%), palm kernel fibers (COD: -69%, turbidity: -95%, nitrates: -70%), and coconut fibers. The latter show optimal performances with a maximum reduction in COD (-7...

Clinical outcomes after cystectomy or unilateral salpingo-oophorectomy for seromucinous borderline ovarian tumors: a single-center retrospective cohort study

Seromucinous borderline ovarian tumor (SMBT) is an uncommon subtype of borderline ovarian tumor characterized by Müllerian-type differentiation and frequent coexistence with endometriosis. Because of its rarity, its clinicopathological characteristics and the oncologic and reprod...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Zebrafish hoxba and hoxbb clusters are redundantly required for posterior pharyngeal pouch development

BACKGROUND: Pharyngeal pouch formation is fundamental to vertebrate craniofacial development, but molecular mechanisms underlying posterior pouch formation remain incompletely understood. Retinoic acid (RA) signaling is required for posterior pharyngeal development, and Hox genes...

Mixed uncertainty information and volatility in the green bond market based on a new two-regime GARCH-MIDAS extension model

Purpose This study pioneers a novel two-regime Generalized Autoregressive Conditional Heteroskedasticity–Mixed Data Sampling (GARCH-MIDAS) extension model to disentangle the dual dynamics of traditional drivers and mixed uncertainty indicators in green bond market volatility. Unl...

Design of Technological Infrastructures in Health and Wellness Tourism and their Effects on Hotel Hospitality: The Case of the Municipality of Lamia

Health and well-being are increasingly pursued through prevention rather than treatment, creating demand for new tourism products and services. This paper examines how technological infrastructures can support health and wellness tourism and how they affect hotel hospitality, usi...

UAV integrated IoT sensing platform for sustainable air quality monitoring and real time AQI estimation

Monitoring modern air pollution requires flexible but portable systems that can be used to gather real-time data in various settings. This paper describes a drone-based air quality monitoring platform with IoT-enabled sensors integrated into it. The system carries multiple gas se...

Expression of Concern: Laparoscopic evidence of upper genital schistosomiasis

We, the Editor and Publisher of Journal of Obstetrics and Gynaecology, are issuing an Expression of Concern for the following article:DARWISH, A. M. M. (1999). Laparoscopic evidence of upper genita...

Phi-132Hz Lattice Braiding Induces Intrinsic Topological Qubit Protection — E8 Intelligence Research

By sequencing the 240 E8 root vectors with phi‑scaled 132 Hz pulses, a braided lattice dynamically rewrites its own phase topology. The resulting 8‑dimensional hypercubic standing wave encodes error syndromes as natural geometric defects, providing intrinsic topological protectio...

Tunable Raman Scattering of Fe(II) Coordination Networks With Magnetic Fields

ABSTRACT Controlling terahertz (THz) waves is important for next‐generation communications, sensing, and imaging technologies. However, it is still unclear precisely how THz signals can be manipulated by various materials. Herein, we report the design and synthesis of four coordi...

Modular Synthesis of γ-Chloro Ketones through Carbochlorination of Alkenes Mediated by Copper(I) Photoredox Catalysis

Abstract γ-Chloro ketones are multifunctional synthons that serve as versatile linchpins for the rapid assembly of molecular complexity. Despite this strategic value, their broader adoption remains conspicuously limited as a consequence of the intrinsic challenges associated with...

Injective attention neural operators for partial differential equations on large-scale problems

Partial differential equations (PDEs) play a central role in modeling physical phenomena across science and engineering, including fluid dynamics, solid mechanics, electromagnetics, and multiphysics systems. Repeatedly solving PDEs over varying inputs, geometries, and parameters...

Engineering of Azo-Crosslinked Alginate Hydrogels for Targeted Oral Local Biologic Delivery

Abstract Oral delivery of therapeutic biologics is constrained by gastrointestinal degradation and premature leakage from physical hydrogels. Here, microfluidic-engineered azo-crosslinked alginate (SA-Azo) microspheres were fabricated via template-assisted covalent substitution,...

The Dancing Sand Theorem — the 2-part of the sandpile group of the hypercube, for every n

Let K(Q_n) be the sandpile group (critical group, Jacobian) of the n-dimensional hypercube graph Q_n. Its odd part was determined by Bai in 2003 (Linear Algebra Appl. 369 (2003), 251–261); its 2-part has been open since then, and the latest work on it (Gao, Marx-Kuo, McDonald, Yu...

The Relationship Between Women's Disaster Preparedness, Genital Hygiene Behaviors, and Menstrual Hygiene Measures

INTRODUCTION: Disasters disrupt access to water, sanitation, privacy, and menstrual hygiene products, thereby increasing women's risk of genital and urinary tract infections and posing a threat to reproductive health. Despite the importance of disaster preparedness, limited evide...

Economic loss assessment of lumpy skin disease outbreak in cattle of Bangladesh

Abstract Lumpy skin disease virus (LSDV) poses a significant economic threat to the cattle sector in Bangladesh, with the first report dating back to 2019. This investigation assessed the financial implications of LSDV outbreaks across eight divisions, including both direct and i...