Research works

Surgical treatment of pancreatic cancer in China: Annual data report of China Pancreas Data Center (2020–2021)

Abstract Objective: The China Pancreas Data Center (CPDC) was established in 2015 with the support of the Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association and initiated prospective data collection in 2017. This article reports contem...

RL-Augmented Dual Robust Adaptive Propagated Interval Observer for Actuator and Residual-Framed Sensor Fault Detection and Isolation in Underactuated AUVs

Reliable fault detection and isolation (FDI) for actuators and sensors in underactuated autonomous underwater vehicles (AUVs) is challenging because nonlinear hydrodynamic coupling redistributes fault signatures, and persistent ocean currents can trigger false alarms. This paper...

Dose-response relationship of prophylactic norepinephrine infusion for prevention of spinal anesthesia-induced hypotension during caesarean delivery: A comparative study of normal weight and obese parturients.

Obese parturients are at increased risk of spinal anesthesia-induced hypotension during cesarean delivery, but optimal prophylactic norepinephrine dosing remains unclear. In this randomized, double-blind, dose-response study, 200 parturients undergoing elective cesarean delivery...

Enhanced ionic conductivity in a sustainable eucalyptus gum-chitosan biopolymer electrolyte for electrochemical device applications

Polymer electrolytes, owing to their distinct characteristics, present a viable alternative to liquid electrolytes in batteries. This study presents a biodegradable polymer electrolyte membrane composed of a blend of eucalyptus gum (EG), chitosan (CS), and ammonium thiocyanate (A...

Quality by Design (QbD) and Experimental Design Strategies in the Development and Optimization of Advanced Drug Delivery Systems: A Comprehensive Review

The increasing complexity of advanced drug delivery systems (ADDS), including nanoparticles, liposomes, transferosomes, polymeric micelles, nanoemulsions, dendrimers, hydrogels, and lipid-based carriers, has necessitated the adoption of systematic, science-driven approaches to fo...

Holographic graphene response from generalized-entropy Smarr residual

Abstract We develop a fixed-geometry entropy-layer framework for testing generalized black-hole entropies beyond local thermodynamic consistency. Holding the seed spacetime, conserved charges, surface gravity, mass normalization, and Smarr weights fixed, we show that every smooth...

Deformation mechanism in laser-powder bed fused Ti-6Al-2Sn-4Zr-2Mo alloy: Role of heat treatment

The deformation mechanisms of heat-treated laser powder bed fused Ti-6Al-2Sn-4Zr-2Mo were investigated using tensile testing and transmission electron microscopy. Heat-treated conditions (solutionized and solutionized + aged) showed improved ductility and non-monotonic strain-har...

EuroMillions Breakthrough Mining — 1293 Sources, 8483 Leads Extracted — E8 Intelligence Research

Mined 1293 lottery+quantum breakthroughs. Extracted 8483 leads across 13 categories. 6617 high-value leads found. Categories: {"CORRIDOR": 683, "FORMULA": 539, "GEOMETRIC": 662, "FORWARD_ATTEMPT": 709, "QUANTUM": 921, "TIMING": 173, "CELESTIAL": 625, "GEMATRIA": 667, "CONSTANT":...

ARTICLE XI : THE 4-DIMENSIONAL COMBAT LOG AND THE EPISTEMOLOGICAL RUPTURE

Classical academia inherently isolates the domains of astrophysics, epidemiology, and computer science, resulting in a fragmented diagnosis of the modern era. This manuscript executes an absolute epistemological rupture, permanently unifying the 2017 interstellar incursion ('Oumu...

The Geometric Ground State: The Complete Catalogue and Litigation of the Zero-Free-Parameter Derivations

This Version 5.0 update to The Geometric Ground State (designated 20-8) serves as the terminal mathematical ledger for the KnoWellian Universe Theory (KUT). It completes the formal catalogue of the twenty primary Zero-Free-Parameter Derivations (ZFPDs) and expands the foundationa...

Global Realism: Spacetime Vacuum as the Unique Physical Reality and Quantum Mechanics as Its Topological Dynamics

We propose a unified physical framework in which four-dimensional spacetime vacuum is the unique physical reality, and all quanta are its localized topological excitations. Matter particles correspond to stable knot-like configurations, while radiation quanta correspond to weak p...

EGFR and TP53 mutations refine prognostic stratification of IDH-wildtype astrocytomas, not elsewhere classified

Abstract IDH -wildtype astrocytomas of histological grade 2 or 3 without the WHO 2021 molecular criteria for glioblastoma— TERT promoter mutation, EGFR amplification, or combined whole-chromosome 7 gain and 10 loss (+ 7/– 10)—are designated “Not Elsewhere Classified” (NEC), a res...

Occupational Health and Safety Practices in Relation to Occupational Injuries Among Iron and Steel Workers

Occupational health and safety (OHS) malpractices may increase the risk of occupational injuries and are a significant public health problem in the iron and steel industries, often leading to disability and death. Information on OHS practices related to occupational injuries in t...

Characterization and evaluation of Nepalese rice landraces using agro-morphological traits

Rice (Oryza sativa L.) landraces represent an important reservoir of genetic diversity for crop improvement. To characterize agro-morphological variation, a total of 63 rice landraces were evaluated using qualitative and quantitative descriptors, with the improved variety Lalka B...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

eDAS: Extending Data Availability Sampling with Privacy and Compliance

A data availability sampling scheme (DAS) allows a network of verifiers to collectively ensure that an untrusted party is correctly storing and distributing some committed data. Importantly, the protocol should not require that the verifiers coordinate or store the full data indi...

Pediatric Endogenous Endophthalmitis: A Decade of Surgical Management and Microbiological Insights

Purpose: To analyze the clinical profile, surgical management, and outcomes of patients with pediatric endogenous endophthalmitis over a decade at a tertiary eye care center in South India. Methods: This retrospective study included 32 eyes of 32 children younger than 15 years. D...

Developmental factors drive the compartmentalized and discontinuous maturation of the small intestinal epithelium during the early postnatal period

The temporal, spatial, and cellular diversity of the small intestinal epithelium during the postnatal period, a critical time window that accompanies the transition from placental energy supply to enteral feeding, and the establishment of the enteric microbiota and postnatal immu...

Structure-Based Insights into the Molecular Mechanisms of LuxR-Type Quorum Sensing Receptors

Quorum sensing (QS) enables bacteria to coordinate collective behaviors in response to population density. LuxI/R QS systems, common among gram-negative bacteria, consist of a LuxI-type synthase that produces an N- acyl L -homoserine lactone (AHL) signaling molecule and a LuxR-ty...

Guns, governance and green futures in West Africa: empirical evidence from fixed effects and quantile models

This paper investigates the impact of institutions, militarisation, and economic growth on environmental pressures in West Africa between 1996 and 2024 with fixed effects and Driscoll-Kraay standard errors and methods-of-moments quantile regression. The study employs CO2 emission...