Research works

Metagenomic Profiling of Diarrheagenic Escherichia coli Pathotypes Reveals Predominance of Diffusely Adherent and Enteroaggregative Subtypes and Mixed Signatures Among Under-Fives in Tanzania

Diarrheagenic Escherichia coli (DEC) is a leading enteric pathogen in children under five in sub-Saharan Africa, yet conventional targeted assays fail to capture mixed virulence signatures or provide quantitative context relative to E. coli carriage. We applied a virulence-aware...

Optimized and Aligned Anisotropic Monte Carlo Sampling Patterns

Abstract Path tracing uses Monte Carlo integration to solve the rendering equation by evaluating the integrand at random sampling points. The convergence rate of the error can be significantly improved by using correlated instead of random sampling, especially on smooth integrand...

Visual strategies in influencer marketing campaigns: The role of consistency

Abstract This research analyzes the role of visual features in influencer marketing campaigns, focusing on visual consistency within campaigns. Using 707 posts and 1,105 stories from 182 campaigns, we extract 47 visual and consistency features along four fundamental visual dimens...

Fisher Information Limits on Genetic Stability, Diversity, and Regulation

Abstract Life and evolution require precise yet imperfect transmission of genetic information across generations. Accurate transmission maintains the genetic blueprint for phenotypes that succeed in current conditions, while some transmission error is necessary to generate herita...

Metallomacrocyclic Ligands Stabilized Icosahedral Superatomic Nanoclusters With NIR‐I to NIR‐II Phosphorescence Modulation

ABSTRACT Coinage metal nanoclusters with near‐infrared‐II (NIR‐II, λ PL > 1000 nm) photoluminescence hold great promise for biological applications. Here, we report the first icosahedral M 13 cluster exhibiting NIR‐II phosphorescence, achieved through an unprecedented metallom...

Angiosarcoma: adaptive designs leveraging vascular biology and antiangiogenic repurposing

INTRODUCTION Angiosarcoma is a rare and aggressive vascular malignancy characterized by substantial clinical and molecular heterogeneity. Grouping UV-associated cutaneous, radiation-associated, and visceral tumors within unselected clinical trials may obscure treatment effects in...

Evaluating Mechanical-EmbeddingML/MM for PredictingMutation Effects in Chorismate Mutase Catalysis

Abstract Predicting how mutations alter enzyme catalysis remains a central challenge in enzymology and enzyme engineering. Although quantum mechanics/molecular mechanics (QM/MM) simulations can in principle compute the activation free energy associated with enzymatic reactions, t...

The Non-Archimedean Ryu-Takayanagi Correspondence: An Exact Isomorphism for p-adic L-Functions

The Non-Archimedean Ryu-Takayanagi Correspondence: An Exact Isomorphism for p-adic L-Functions Abstract: The p-adic Holographic L-Function Isomorphism establishes a rigorous, mathematically exact framework that maps the analytic behavior of p-adic L-functions for higher-rank modu...

How Does Incentive-Based Environmental Regulation Promote Employment? A Quasi-Natural Experiment Based on Carbon Trading Rights Pilot

Treating the pilot carbon emissions trading policy as a quasi-natural experiment, this study employs a multi-period difference-in-differences model to assess its employment effects using panel data from Shanghai and Shenzhen A-share listed companies between 2007 and 2022. Results...

Keeping people with dementia moving in hospital to reduce pressure ulcer risk: complexities in care

People with dementia occupy up to 21% of UK hospital beds at any one time and are at increased risk of developing pressure ulcers. Keeping moving is a fundamental component of pressure ulcer prevention. However, the physical, behavioural and psychological symptoms of dementia can...

Comparative assessment of water quality and cyanobacterial toxin risks in Lake Chivero and Lake Kariba, Zimbabwe

Concerns regarding the degradation of aquatic ecosystems and the production of toxins resulting from water pollution and eutrophication are increasing. The study was carried out to compare water quality and algal communities of Lake Chivero, a hypereutrophic lake, and Lake Kariba...

Inter-system differences in modelling approaches for shoulder joint kinematics between markerless and marker-based motion capture during baseball pitching

Comparative data on markerless motion capture systems for upper-extremity kinematics during high-speed movements remain limited. We aimed to examine inter-system modelling differences in shoulder joint kinematics between a markerless motion capture system (Theia3D) and a marker-b...

PREDICTION OF ALPHABET INC. (GOOGL) STOCK PRICE USING CNN, LSTM, AND GRU ALGORITHMS BASED ON K-FOLD CROSS VALIDATION

This study compares three single deep learning architectures — Convolutional Neural Network (CNN), Long Short-Term Memory (LSTM), and Gated Recurrent Unit (GRU) — on the daily closing price of Alphabet Inc. (GOOGL), using an evaluation scheme that preserves the chronological orde...

Enabler or Divider? The Enabling Effects and Digital Divide Consequences of Digital Inclusive Finance on Regional Entrepreneurship

This study investigates the impact of digital inclusive finance on regional entrepreneurship using panel data from 327 Chinese cities spanning 2011 to 2023. Employing bidirectional fixed effects models, mediation analysis, and heterogeneity analysis, we find that digital inclusiv...

Diagnostic Methods for Detecting Dental Cracks: A Systematic Review

Background: Dental cracks are a common yet diagnostically challenging condition due to their asymptomatic clinical nature and difficulty in early detection. Accurate diagnosis is essential to prevent crack progression and potential tooth loss; however, no universally accepted dia...

Assessing Inequality of Financial Opportunity in China: A Machine Learning Approach

ABSTRACT Measuring inequality of financial opportunity is important for understanding disparities in financial resource allocation and their fairness implications. This study employs machine learning techniques to deliver a data‐driven assessment of financial opportunity inequali...

An RL-Inspired Probabilistic Updating Heuristic for Mode Selection in Modular Construction Scheduling

Multi-mode project scheduling, in which each activity can be executed in one of several alternative modes with distinct duration and resource requirements, represents a challenging combinatorial optimization problem prevalent in modular construction and manufacturing. While metah...

Performance evaluation of supervised machine learning models for Pb2+ ions detection in water using AlGaN/GaN high electron mobility transistors

Abstract In this work, a comparative machine-learning-based framework is developed for the binary classification of Pb 2+ ions presence in aqueous medium using 2, 5-dimercapto 1,3,5, thiadiazol functionalized AlGaN/GaN high electron mobility transistor (HEMT)-based sensor respons...

Integer Circulant Determinants of Order 20

For F in Z[X], set M_20(F) = Res(X^20 − 1, F) and S_20 = {M_20(F) : F in Z[X]}. This preprint determines S_20 completely. Write a nonzero integer as D = ±2^a 5^b m, where m ≥ 1 and gcd(m,10) = 1. The local conditions a = 0 or a ≥ 4 and b = 0 or b ≥ 2 are sufficient except on exac...

HetCA/STOCSY‐Guided Dereplication of Artemisia arborescens Reveals Furofuran Lignans with Antileishmanial Effects

Natural products represent an important source of bioactive compounds; however, their complexity often challenges conventional discovery approaches. In this study, an ethyl acetate extract of Artemisia arborescens (Vaill.) L. was investigated prior to any isolation using an integ...