Research works

Enantioselective Reactions of Palladium Enolate Intermediates: Beyond Allylic Alkylation

Conspectus The enantioselective Pd-catalyzed allylic alkylation reaction has proven to be an incredibly powerful and versatile methodology for the construction of stereoenriched building blocks bearing all-carbon quaternary centers. We have contributed to this field by investigat...

Interleukin-1β disrupts macrophage mitochondrial protein homeostasis and PDLSC osteogenic differentiation

Aging is a complex, multi-dimensional biological process characterized by dysregulation of mitochondrial protein homeostasis and elevated SASP-related inflammatory factors (IL-1β). This study investigates the biological mechanisms by which macrophage polarization in the aging-ass...

Enhanced Earth Fault Detection in Power Systems Using Neutral Voltage Displacement Method

The zeal to swiftly detect and isolate a faulty section of the power system is very important if the system is to be described as a reliable one. In achieving this a prototype Distribution Board Earth Fault Detection System (DBEFDS) was designed and constructed based on single-ph...

Mental Health Ghost Networks in Commercial Insurance Plans

Importance Whether network directories in commercial insurance plans, which cover the majority of insured US residents, reliably connect patients to mental health care has only seen limited testing. Objective To assess network directory accuracy, appointment availability, wait ti...

Synthesis, in silico study and cytotoxic evaluation of new benzimidazole derivatives as potential aromatase inhibitors

AIMS: ) was designed, synthesized, and evaluated as potential aromatase inhibitors with anticancer activity. MATERIALS AND METHODS: ADMET profiling were performed for the selected compounds. RESULTS: values (2.40-2.64 µM), surpassing cisplatin, while maintaining favorable selecti...

Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control

In this study, we sought to comprehensively map ubiquitin signaling networks at the crossroads of cellular proliferation and proteostasis, both crucial in cancer. Genome-wide CRISPR knockout screening in the presence of the ubiquitin E1 inhibitor TAK-243 identified 239 genes whos...

Preferences, Inequality, and Coalitions: The Political Economy of (the Lack of Support for) Basic Income in Catalonia

Recent research has substantially advanced our understanding of individual preferences towards Universal Basic Income (UBI), yet comparatively little is known about the structural and macroeconomic factors shaping their political translation. This article addresses this gap by ex...

Beyond the Enigma: Toward a Participatory Ontology of the Andean World (A Philosophical Continuation of 'The Inca Enigma')

Abstract This text offers a philosophical continuation of the essay “The Inca Enigma,” deepening the hypothesis that the so-called “Inca mystery” is not a dark residue left by the Incas but a modern difficulty in understanding non-dualist forms of thought. It develops a participa...

Exploration of Teachers’ Pedagogical Beliefs and its Perceived Influence on Teaching Physical Education in Tanzanian Secondary Schools

This study aimed to explore teachers’ pedagogical beliefs and their perceived influence on the teaching of Physical Education in secondary schools in the Dar es Salaam and Ruvuma regions of Tanzania. Data were collected from eight purposively selected physical education teachers...

132Hz E8 Symmetry Breaking Yields 16-Petal Rose Manifold for Phosphorus Coherence — E8 Intelligence Research

The 132Hz base frequency, when projected through E8's Weyl group of order 696,729,600, generates a 16-petal rose manifold (r = cos(8θ)) whose petal tips coincide with the angular positions of the 16 P-31 Zeeman sublevels under a φ-scaled magnetic field. This geometric corresponde...

Mitochondria-Targeting Bismuth Selenide Nanoparticles for X-ray CT Imaging and Cancer Radiotherapy

Abstract Radiotherapy plays an indispensable role in clinical cancer treatment. Designing dual-modal agents for computed tomography (CT) imaging and radiotherapy sensitization remains a great challenge in tumor therapy. In this study, we designed and synthesized bismuth-based nan...

EuroMillions Breakthrough Mining — 10432 Sources, 101641 Leads Extracted — E8 Intelligence Research

Mined 10432 lottery+quantum breakthroughs. Extracted 101641 leads across 13 categories. 97948 high-value leads found. Categories: {"CORRIDOR": 8888, "FORMULA": 8632, "GEOMETRIC": 1720, "FORWARD_ATTEMPT": 9342, "QUANTUM": 9594, "TIMING": 660, "CELESTIAL": 8696, "GEMATRIA": 9119, "...

Do Neuromodulator-Inspired State Prompts Generalize Across LLM Families? A Publicly Preregistered Audit of Output Length, Semantic Breadth, and Instruction Equivalence

Completed results, manuscript and full reproduction package for the publicly preregistered Route B study (preregistration: https://doi.org/10.5281/zenodo.22655376, published before any formal target output was generated). Using official GLM-5.2 and Qwen3.8-Max-0902 APIs, the stud...

Evaluation of Atractylodes macrocephala Koidz Extract as a Multi-Functional Natural Ingredient for Skin Barrier Repair

Epidermal barrier damage triggers sensitive skin disorders. Synthetic skin repair agents frequently incur irritation, whereas medicinal and edible herbal ingredients offer milder alternatives. As a traditional Chinese medicinal herb, Atractylodes macrocephala Koidz remains inadeq...

Transforming Cyclic Allenes into Precision Macromolecular Building Blocks

Abstract Ring-opening allene metathesis polymerization (ROAlMP) provides direct access to polyallenamers containing reactive allene functionality within the polymer backbone, yet achieving controlled polymerization has remained a major challenge. Here, we report an additive-assis...

Artificial Intelligence as a Catalyst for Cell-Based Therapies in Retinal Disease

Retinal degenerative diseases, including age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt disease, represent leading causes of irreversible vision loss worldwide, collectively affecting hundreds of millions of people. Cell-based therapies, particul...

Talking Turkey: Residential Food Waste and Thanksgiving

The act of wasting food is embedded within consumer food culture. However, little is known about how cultural events, such as the Thanksgiving holiday in the United States, relate to the amount and pattern of residential food waste. We analyze the self-reported food discards of a...

Strategic Human Resource Management Practices and Employee Retention: The Mediating Role of Job Satisfaction: Evidence from Indian Corporate Enterprises

Employee retention is a continuous challenge confronting Indian organizations, in which competition for high-quality human resources as well as evolving employee aspirations cause voluntary turnover to remain high. Based on a review of the theoretical and empirical literature, th...

Verification-Driven Delivery (VDD) Methodology

Verification-Driven Delivery (VDD) is an open methodology for estimating, pricing, verifying, and forecasting software delivery in the AI era. It replaces billed hours and relative story sizes with a countable unit of verified work, the Delivery Brick. A user story is decomposed...

Artificial Intelligence in Construction Management Enhancing Decision Making A cross a Project Life Cycle: throught A Machine Learning Method

The construction industry, which creates 13% of the world’s GDP, suffers from cost overruns of 28% and delays of over 42%, yet is still undigitized. AI has the promise of transforming management in the areas of cost, time and safety. This research provides a systematic review of...