Synthesis, in silico study and cytotoxic evaluation of new benzimidazole derivatives as potential aromatase inhibitors
Abstract
AIMS: ) was designed, synthesized, and evaluated as potential aromatase inhibitors with anticancer activity. MATERIALS AND METHODS: ADMET profiling were performed for the selected compounds. RESULTS: values (2.40-2.64 µM), surpassing cisplatin, while maintaining favorable selectivity profiles. CONCLUSIONS: as a promising lead for further development as a non-steroidal aromatase inhibitor for breast cancer therapy.
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Authors: Ayşen Işık, Nour El-Huda Daoud, Kezban Uçar Çifci, Gülşah Çongur, Ebru Nur Ay, Emine Rana Bağcı, Şennur Görgülü, Ulviye Acar Çevik, Yusuf Tutar, Yusuf Özkay, Zafer Asım Kaplancıklı
Institutions: Istinye University, Recep Tayyip Erdoğan University, Yozgat Bozok Üniversitesi, Al-Ahliyya Amman University, Afyonkarahisar Sağlık Bilimleri Üniversitesi, Selçuk University, Anadolu University, Bilecik Şeyh Edebali Üniversitesi