Research works

Benchmarking a new urban scheme in the ORCHIDEE 2.2 land surface model

Urban areas change natural surface energy and water balances, yet some land surface models still represent cities as natural surfaces. In this study, we present the development of a one-tile urban scheme for the ORCHIDEE land surface model, designed to improve the representation...

Prone Positioning in Neurocritical Care Patients with Invasive Intracranial Pressure Monitoring: A Systematic Review and Meta-analysis

Abstract Background Pulmonary complications are common after acute brain injury and may worsen neurologic outcomes. Although prone positioning (PP) is an established treatment strategy for acute respiratory distress syndrome (ARDS) with severe hypoxemia in general intensive care...

Potential health impacts and costs of active case finding guided by Mycobacterium tuberculosis immunoreactivity survey results in Blantyre, Malawi: A mathematical modeling study

Background Active case finding (ACF) for tuberculosis (TB) can reduce transmission, yet efficient targeting requires high-quality surveillance data. We investigated the potential costs and impact of targeted ACF, guided by local estimates of the annual risk of TB infection (ARTI)...

Using dapagliflozin to reduce symptoms in transthyretin cardiac amyloidosis: An n-of-1 trial series pilot study

Background The role of guideline-directed medical therapy for heart failure (HF) is unclear in transthyretin amyloid cardiomyopathy (ATTR-CM). Dapagliflozin has demonstrated beneficial effects across HF phenotypes, and retrospective studies suggest potential benefit in ATTR-CM; h...

Quantification of Carbon, Water, and Energy Footprints Associated with Refined Cane Sugar Production in Mexico Through Life Cycle Assessment

Integrated life cycle assessments combining carbon, water, and energy footprints are uncommon for cane sugar production in Mexico, particularly in high-productivity regions where aging infrastructure substantially affects environmental performance. This study quantified these thr...

Fraud Among Young Adults: A Scoping Review of Victimization and Perpetration

This scoping review synthesized evidence on fraud victimization, perpetration, and prevention among young adults aged 18–25. Eighteen studies were included, predominantly quantitative and from China and the United States. Fraud types were inconsistently defined and rarely the pri...

Determinants of Crime in India: A District-Level Analysis

This paper examines the district-level socioeconomic factors of reported crime in India using data from the NCRB and the Census of India. Using a cross-sectional sample of 481 districts across 17 major states, the study treats female-to-male ratio and inequality as main variables...

DA-MC-SEP: a distance-aware multi-hop clustering and stable election protocol for heterogeneous WSNs

Abstract Wireless Sensor Networks (WSNs) consist of large numbers of sensor nodes (SNs) operating under strict energy constraints, making efficient routing protocols essential for extending network lifetime and ensuring reliable data delivery. This paper introduces a Distance-Awa...

Emotional predictors of returning a favour: Behavioural experiments in the United States and Japan

Abstract We examined emotional predictors of favour‐returning behaviour in the United States (Study 1) and tested whether the findings in the United States would replicate in a culturally different context in Japan (Study 2). In both experiments, participants played a collaborati...

A generalizable biopsychosocial risk score for stratifying disease vulnerability in healthy populations

Prospective risk stratification of future adverse health outcomes before clinical onset among ostensibly healthy individuals is an important goal of preventive and precision medicine, yet current tools remain largely disease-specific and do not provide an integrated measure of he...

Fuzzy multi objective solid transportation model for optimal distribution

This study demonstrates a novel fuzzy multi-objective solid transportation problem (FMOSTP) which optimally manages logistics chain under uncertainty by simultaneously addressing multiple conflicting criteria cost, transit time, and security represented as fuzzy numbers. The prop...

Voice-First Mental Health Care for Older Adults in Africa

This Viewpoint proposes voice-first systems as a design hypothesis warranting priority development and evaluation to support mental health care for older adults in Africa.

Escherichia coli -derived enterobactin is associated with delayed gut microbiome maturation in infants born to mothers with obesity

ABSTRACT Maternal obesity has been increasingly recognized as a factor influencing early-life microbiome development. However, its impact on the infant gut resistome and virulome remains insufficiently characterized. In this prospective longitudinal study, we investigated gut mic...

Corticosteroids drive oral candidiasis by impairing type-17 immunity without inducing interferon-gammopathy

ABSTRACT Oral candidiasis arises from either genetic immune defects or iatrogenic immune suppression, most commonly due to corticosteroid therapy. Although the cortisone acetate mouse model is widely used to study corticosteroid-associated oral candidiasis, the underlying mechani...

The chromatin-organizer Satb1 modulates regulatory T cell activity within the tumor microenvironment

Regulatory T cells (Tregs) are essential for maintaining immune homeostasis and preventing autoimmune diseases, but are also a major cellular constituent of the tumor microenvironment (TME) that facilitates cancer progression. Identifying differences in Treg subtypes to specifica...

Transient receptor potential channel activation targets multiple stages of the schistosome parasite

Schistosomiasis, a neglected tropical disease caused by infection with parasitic blood flukes of the genus Schistosoma , affects more than 250 million people worldwide. Currently, patients rely on a single medicine, praziquantel (PZQ), discovered half a century ago. To combat dru...

Association of PTH1R Gene Polymorphisms with Three-Dimensional Mandibular Morphology Across Three Recruitment Cohorts

Parathyroid hormone 1 receptor (PTH1R) regulates chondrocyte differentiation and mandibular condylar cartilage development, but its contribution to adult mandibular morphology remains unclear. We investigated associations of two PTH1R single-nucleotide polymorphisms (SNPs), rs724...

Hierarchical Core‐Shell Phase‐Change Fibers for Active‐Passive Thermal Management, Multimodal Sensing, and Infrared Camouflage

ABSTRACT The continuous development of smart textiles calls for multifunctional fibers that can simultaneously achieve thermal energy storage, active heating, and real‐time sensing. Using an emulsion‐based wet‐spinning strategy, thermoplastic polyurethane/octadecane/poly(3, 4‐eth...

Mass Protest and Civil Society Positioning in Romania

Romania's contentious politics has been undergoing significant change in recent times, most visibly marked by repeated cycles of mass protest. Based on political ethnographic research conducted in Romania, this study conceptualises this process by exploring activists’ meaning-mak...

DOE‐Based Sensitivity Analysis for Rational Constitutive Parameter Selection in Coupled Hydro‐Mechanical Simulations of Test in Unsaturated Soils

ABSTRACT The Barcelona Basic Model (BBM) is the most well‐known elasto‐plastic constitutive model for describing the behavior of unsaturated soils. However, the selection of BBM parameters from laboratory data remains challenging due to the strong coupling and interdependence amo...