Research works

Immune response to DNA and RNA: structural insights, molecular mechanisms, and therapeutic targeting

Abstract The recognition of mislocalized DNA and RNA by cGAS–STING, RIG-I/MDA5, the OAS–RNase L axis, and endosomal TLR3/7/8 has emerged as a unifying paradigm linking cancer, autoinflammation, and antiviral immunity. Counterbalancing these sensors is a structurally heterogeneous...

Hydrogen 1s Orbital from Stochastic Collapse Testing the Quantum Measurement Problem via the Fine-Structure Constant

We test a recently proposed algebraic resolution of the quantum measurement problem by deriving the fine-structure constant from the same dissipative collapse dynamics, and by verifying that the resulting stochastic collapse reproduces the Schrödinger distribution for the hydroge...

Predominant NR1-positive puncta with limited PSD95 colocalization and close GluA2–EAAT2 apposition in the preBötzinger complex

Abstract The preBötzinger complex (preBötC) is a medullary network that generates the inspiratory phase of respiratory rhythm in mammals and depends critically on glutamatergic transmission. To characterize the anatomical organization of excitatory signaling elements within this...

Multidisciplinary Design Coordination as a Driver of Building Resilience in Complex Saudi Projects

Building resilience is frequently discussed as a property of structure, envelope, mechanical systems, emergency power or digital controls. In practice, however, the building succeeds or fails through their interaction. A compliant component can still contribute to service loss wh...

“If you go on reading, everything becomes clearer”: reader responses to (un)cooperative narration in Klara and the Sun

Abstract The present contribution offers a twofold pragmatic literary stylistic analysis of Kazuo Ishiguro’s speculative fiction novel Klara and the Sun in order to understand how readers engage with non-human, uncooperative narration. Firstly, the narrative style of the text wil...

Parent–child connectedness and its associations with sexual risk behavior and outcomes among young people: a systematic review and meta-analysis

Significant disparities in the sexual and reproductive health of young people persist globally. Although previous systematic reviews and meta-analyses have largely focused on the effects of parenting practices, such as parent–child communication and parental monitoring, on sexual...

Perioperative stress–inflammation–immunosuppression axis and tumor progression: mechanistic integration and anesthetic management strategies

Abstract Perioperative stress is an unavoidable part of surgery and may be particularly relevant in patients with cancer. Surgical trauma activates two major stress pathways, the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic nervous system (SNS), leading to surges...

Piperazine linked chitosan schiff base nanoparticles as a novel antibiofilm and antibacterial strategy against clinically relevant pathogens

Abstract The development of multifunctional antimicrobial materials capable of targeting both planktonic bacteria and biofilm-associated infections remains a critical challenge in combating antimicrobial resistance. In this study, a novel piperazine-linked chitosan Schiff base (C...

Mechanochemical synthesis of complex ceramic oxides: a sustainable route to high-performance functional materials

Abstract Ceramic materials play a vital role in advanced electronic, optical, and energy applications due to their unique structural and functional properties. This review focuses on the mechanochemical synthesis (MCS) of complex ceramic oxides such as BaTa₂O₆, MgTa₂O₆, and BaTiO...

Tigecycline pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation: a prospective multicentre pilot study

Abstract Background Tigecycline is frequently used to treat multidrug-resistant infections in critically ill patients. However, its pharmacokinetics in patients receiving extracorporeal membrane oxygenation (ECMO) are poorly defined, raising concerns about the adequacy of standar...

PFUSRC-132I Gödel's Incompleteness Theorems and the Boundary of Three-Dimensional Static Slice: Layer Attribution Repositioning

Gödel’s two incompleteness theorems form a core conclusion of modern mathematical logic: every consistent, recursively axiomatized formal system containing complete Peano arithmetic necessarily carries undecidable true propositions unprovable within the system itself. This paper...

Raw Clay-AssistedFenton Removal of Dark Blue ReactiveDye: Experimental Assessment Supported by DFT Insights

Abstract This study examines the removal of the azo dye dark blue (DB) using natural raw clay as an iron-bearing material in a clay-based Fenton system. Characterization of the natural mineral via XRD, FTIR, and SEM/EDX confirmed a quartz-rich structure containing native iron. Th...

Epitactic Growthduring the Fluid-Driven Aragonite-to-CalciteTransformation

Abstract Aragonite and calcite (CaCO3) are the most abundant polymorphs of calcium carbonate in the Earth’s crust and are relevant industrial minerals. The factors that control the solid-state transformation of aragonite, the high-pressure polymorph, into calcite, the stable poly...

IgG4-related lung disease and seropositive undifferentiated arthritis in a patient initially presenting with monoarthritis: a case report

Abstract Background IgG4-related lung disease (IgG4-RLD) is a fibroinflammatory pulmonary manifestation of IgG4-related disease (IgG4-RD). Its comorbidity with seropositive undifferentiated arthritis (SUA) is rare and may be overlooked due to overlapping clinical and immunologica...

StateWeaver: Tracing State Changes in Adaptive Molecular Dynamics

Adaptive molecular dynamics produces many short simulations that begin from frames of earlier runs. This branching improves sampling, but it makes a simple question hard to answer: when a state-transition probability changes, which simulations produced the change? StateWeaver joi...

Beyond risk factors: a mixed-methods study of interpersonal dynamics in suicide attempts and reattempts from police narratives

Abstract Background Each year, approximately 1.5 million Americans attempt suicide, and repeated attempts pose heightened risks for individuals, families, and communities. These attempts can result in long-lasting injuries, isolation, and psychological distress. Research relies h...

Association between hemoglobin-to–HDL cholesterol ratio and long-term major adverse cardiovascular events in STEMI patients undergoing PCI

Abstract Background Residual cardiovascular risk remains high in patients with ST-segment elevation myocardial infarction (STEMI) despite successful primary percutaneous coronary intervention (PCI). Hemoglobin and high-density lipoprotein cholesterol (HDL-C) are routinely measure...

Identification and functional characterization of the PP2C gene family reveal their negative regulatory roles in stress adaptation in Solanaceae

Abstract Background The plant protein phosphatases 2C (PP2Cs) are key regulators of plant growth and development, hormone signaling, and responses to environmental stresses. In Solanaceae crops, which are frequently challenged by environmental stresses leading to yield losses, a...

Airway management in acutely poisoned patients with Glasgow Coma Scale less than 9: a retrospective cohort study

Abstract Background A Glasgow Coma Scale (GCS) ≤ 8 is frequently used to guide prehospital intubation, but its generalizability to acutely poisoned patients is uncertain. We compared outcomes of poisoned patients with GCS ≤ 8 managed with or without prehospital intubation. Method...

Reusing Erasure-Biased OAM Diffusion as a Storage Resource: A Loop-Buffer Memory and Its Loss Budget (v2)

Abstract / Description A companion note introduced an orbital-angular-momentum (OAM) cat-qubit encoding in which local, nearest-neighbor mode-mixing along a propagation channel converts almost all population leakage into a detectable erasure, with logical bit-flips suppressed exp...