Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
35001 work(s)
- BiologyOpen access
Abstract Although human pluripotent stem cells (hPSCs) can generate all tissues of the body, hPSCs in vitro frequently exhibit differentiation biases or failure that pose substantial challenges for disease modeling and regenerative medicine. The origins of these biases remain inc...
- Health & MedicineOpen access
ZPY-CpG-Ch, a broad coverage vaccine against Streptococcus pneumoniae
Existing licensed pneumococcal vaccines, including Prevnar-13 and its higher-valency successors, have played a major role in reducing invasive pneumococcal disease worldwide. However, their effectiveness is increasingly threatened by the rise of multidrug-resistant strains and th...
- AI & ComputingOpen access
Preparing general mixed quantum states on quantum computers
<title>Abstract</title> The preparation of quantum states serves as a pivotal subroutine across various domains, including quantum communication protocols, quantum computing, and the exploration of quantum correlations and other resources within physical systems. Building upon th...
- Society & EconomicsOpen access
Investigating a real-time adaptive procedure system
Procedural issues are significant contributors to incidents in high-risk industries, yet current procedures fail to accommodate the gap between how work is prescribed and how it is actually performed. This study investigates the feasibility of developing a Real-Time Adaptive Proc...
- BiologyOpen access
Autonomic Time: The Temporal Signatures of the Polyvagal States
Reframes the three polyvagal states as three worlds of time: sympathetic as the compressed future, dorsal as the foreclosed future, and ventral as the lengthened present — the exhale in which the durational read becomes possible. Extends polyvagal theory into Temporal Somatics. P...
- Society & EconomicsOpen access
The Temporal-Somatic Floor of Adult Development: Why Self-Authoring Requires a Livable Present
Identifies the body's relationship to time as the deepest 'subject' in Kegan's constructive-developmental theory and the somatic-temporal floor beneath every order of mind. Argues that self-authoring requires a present long enough to write in, and points beyond order 5 toward Cor...
- AI & ComputingOpen access
The Theory of Data develops a foundational framework for governed analytical data, lawful transformation, and certification. A datum is one typed value at one anchor point. A member is a homogeneous typed partial function binding datums over one anchor within one universe. A meas...
- Society & EconomicsOpen access
The Temporality of Coral (Kegan 5.5): Where Time and Soma Fuse into a Single Precise Indicator
Posits a developmental station beyond Kegan's fifth order — provisionally Coral (Kegan 5.5) — at which past and future resolve into a single operant future-past, the body becomes a processing mind-center, and time and soma fuse into a precise (savant-grade) indicator of wholeness...
- Society & EconomicsOpen access
The Durational Read: A Method for Metabolizing the Body's 'Bad' as the Signature of Becoming
A repeatable method — the durational read — for holding an aversive somatic signal across time until its valence resolves from 'bad' to the felt-sense of becoming. Distinguished from dissociation, spiritual bypassing, and endurance; grounded in titration (Levine) and ventral-stat...
- BiologyOpen access
This paper proposes Temporal Somatics — the study of how the living body holds, orients to, paces, and metabolizes time — as a distinct field, and argues that no theory of human development is complete without it. Its central law is temporal: the body's ceaseless signal that some...
- Biology
An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation
Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...
- Biology
A genotype-first approach reveals the molecular basis of pyrin inflammasome activation
Mutations in the MEFV gene, which encodes pyrin, are associated with a spectrum of inflammatory conditions called pyrin-associated autoinflammatory diseases (PAADs). Of the 400 MEFV variants listed in the Infevers database, most are classified as variants of uncertain significanc...
- Biology
An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation
CDC42 is an evolutionarily conserved guanosine triphosphatase (GTPase) regulating critical cellular and immune processes. Variants in CDC42 therefore cause a spectrum of developmental phenotypes, including hematological and immunological symptoms. Here, we identify a previously u...
- AI & ComputingOpen access
The Three Differences and the Phenomenology of the Lateral Difference
A working note distinguishing three differences — ontological (what obtains / how it obtains), categorial (how / how), and lateral (this own / another own) — and developing the phenomenology of the third. It is deposited as the candidate articulation of a preregistered identity t...
- AI & ComputingOpen access
Regime Has a Contract: Intervention, Observation, and the Data Foundation of Causal Identification
The Theory of Data distinguishes event and spine universes by their point-existence laws but does not, by that distinction alone, specify how values are generated at those points. This paper introduces regime as a separate governed object: the value-generation arrangement under w...
- Society & EconomicsOpen access
The Three Differences and the Phenomenology of the Lateral Difference
A working note distinguishing three differences — ontological (what obtains / how it obtains), categorial (how / how), and lateral (this own / another own) — and developing the phenomenology of the third. It is deposited as the candidate articulation of a preregistered identity t...
- Health & MedicineOpen access
Sudden outbreaks of exudative epidermitis (EE) are managed with antibiotics. This retrospective observational study evaluated the antimicrobial susceptibility of Staphylococcus (S.) hyicus strains isolated in Northern Italy between January 2022 and April 2025. Isolates were recov...
- Biology
Abstract This study evaluated the impact of synbiotic formulation on lactic acid bacteria (LAB) viability and quality attributes of yogurt during cold storage. Yogurt was manufactured with traditional starter cultures ( Lactobacillus delbrueckii subsp. bulgaricus and Streptococcu...
- Health & MedicineOpen access
BACKGROUND: Over 100,000 patients undergo ACLR each year in the United States, providing rich electronic medical record data to improve outcomes, but manual chart review can be time-consuming and expensive. Natural language processing (NLP) methods have been successfully used to...
- Engineering & TechnologyOpen access
Improved building performance prediction model based on the OODA-MDOB approach
Abstract The neglect of subjective factors such as cost consideration and accessibility in occupant behavior models leads to unrealistic device usage simulations, which ultimately undermines prediction accuracy. To address this gap, this paper proposes a Multi-Device Occupant Beh...