Research works

DNTTIP2 coordinates RNA exosome activities to ensure fidelity of human ribosome assembly

Abstract The RNA exosome-associated helicase Mtr4/MTR4 (yeast/human) is recruited by adaptor proteins bearing Arch-Interacting Motifs (AIMs) to selectively degrade RNA substrates. Although the exosome targets diverse RNAs, only a few adaptors have been identified. Here, we extend...

Urethral Metastasis of Therapy‐Induced Neuroendocrine Prostate Cancer Successfully Managed With Chemoradiotherapy: A Case Report

ABSTRACT Introduction Urethral metastasis of prostate cancer is exceptionally rare, particularly in castration‐resistant disease. Therapy‐induced neuroendocrine prostate cancer (t‐NEPC) is an aggressive variant with limited treatment options. Case Presentation A 72‐year‐old man,...

U.S. wildfire-power grid risk: A review of policy & practices in ten western states

Record-breaking fires in the western U.S. have drawn considerable scrutiny of the risks associated with wildfires and the power grid. Electricity infrastructure can both cause and be impacted by wildfires, at times forcing planned shutoffs. As utilities rapidly deploy mitigation...

Applications of the pattern evolution research: modelling the evolutionary dynamics of historical script systems

Abstract Pattern systems are abstract communication frameworks composed of symbols, syntactic rules, and semantic structures. This study introduces the theoretical foundations of Deep Feature Phylogenetics as a model-free approach to the evolution of symbolic systems. Unlike trad...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...

Impact of surface division and zone characteristics on outdoor surface temperature modeling with EnergyPlus

Several graphical user interface (GUI) tools used by energy modelers are powered by EnergyPlus, a widely recognized building energy modeling engine. Recent advancements in these tools have improved the creation of building geometries for energy modeling. Ladybug Tools, a Grasshop...

Metabolite changes in Chionanthus retusus

Changes of metabolites in individual plants of high and low oily Chionanthus retusus at different developmental stages

Strain Effectson the Mechanical Properties and GasAdsorption and Diffusion Characteristics of Anthracite

Abstract The coal matrix is subjected to complex strain conditions during exploration. Pore structural evolution, gas adsorption, and diffusion characteristics of high-rank coal matrix under uniaxial compressive and tensile strain conditions are investigated through molecular sim...

Determination of Sodium Carboxymethyl Cellulose in Diluent of Risperidone Injectable Suspension via Dische Reaction

Sodium carboxymethyl cellulose (NaCMC) is a commonly used pharmaceutical excipient; however, no analytical method has been specifically reported for its determination in the diluent of risperidone injectable suspension. In this study, a simple and cost-effective spectrophotometri...

Anterior cruciate ligament rupture during a cognitively demanding change-of-direction task in football: biomechanical insights from a laboratory injury

Abstract Background In laboratory-based injury risk assessments, there is always a small and not entirely avoidable risk of injury to participants. This case report describes an anterior cruciate ligament (ACL) re-rupture of a female participant during the approach run of a stimu...

Field evaluation of polished desalinated produced water for alfalfa irrigation in a semi-arid environment

Abstract Water scarcity is a critical challenge in West Texas, where agriculture and the oil and gas industry compete for limited water resources. The oil and gas industry generates approximately 32% of the nation’s produced water, presenting significant opportunities for benefic...

Patellofemoral outcomes after kinematic versus mechanical alignment in primary total knee arthroplasty

Aims: Concerns persist that kinematic alignment (KA) in primary total knee arthroplasty (TKA) may adversely affect the patellofemoral (PF) joint, because most contemporary components were developed under mechanical alignment (MA) principles. This focused scoping review mapped hea...

Effect of palatal shape on dental arch relationships in unilateral cleft lip, alveolus, and palate

INTRODUCTION: Palatoplasty is a critical surgery for restoring structure and function in patients with cleft palate, but surgical scarring is considered a major factor in maxillary growth deficiency and abnormal dental arch relationships. Palatal scars can significantly alter pal...

Enabling generalizable RUL prediction for equipment: a dual-dimensional continual learning approach based on deep Gaussian process

Abstract Accurately predicting Remaining Useful Life (RUL) is critical for the intelligent maintenance of high-end rotating machinery, which often operates under complex and variable conditions. However, conventional predictive models tend to degrade in performance when deployed...

Calculation of Planck's Constant from the Electric Charge of the Photonic Etheron

The present work demonstrates that the Planck constant is not a merely empirical parameter, but derives directly from the dynamical structure of the photon described by the MODEC (Double-Helical Model of the Photon) [1], and specifically from the electric charge modulus of the tw...

Adaptive Terrain Memory Navigation: A Modular Fail-Safe for Unmanned Aerial Vehicles in Satellite-Navigation-Denied Environments

Tactical unmanned aerial vehicles (UAVs) rely almost exclusively on GPS and a radio-control (RC) link for navigation and recovery. Either link can fail independently — through deliberate jamming or spoofing, terrain and weather blockage, or physical damage to the receiver hardwar...

Collision-InducedDissociation Study of Isomeric TetrahydrocarbazoleCarboxylic Acids Relevant to Corrosive Petroleum Crudes

Abstract Positional isomers of carboxylic acid-substituted tetrahydrocarbazole (Schemes 1A and 1B) were studied as model compounds for the N1O2 class of neutral nitrogen species in heavy crude oils with elemental composition CcHhNnOo (where n is 1 and o is 2). These species can c...

Vulnerable groups’ engagement with interventions to mitigate the health impacts of exposure to extreme temperature events: a qualitative systematic review

Abstract Extreme temperature events are becoming more frequent. Such events are defined as unusually hot weather persisting for at least two consecutive days (heatwave) or unusually cold weather persisting for at least two consecutive days (cold wave) within the context of geogra...

Randomized controlled trial of GenAI coach feedback efficacy, acceptability and mechanisms in anxiety worry logs

Abstract Anxiety disorders are prevalent worldwide, yet access to evidence-based interventions remains limited. Digital worry-log interventions are scalable, but unguided use may limit engagement and efficacy, while human-delivered feedback may improve outcomes, yet is labor-inte...

The Importanceof First-Principles in the Era of ArtificialIntelligence: A Perspective on Hybrid Modeling and Industrial CaseStudies

Abstract In this work, we will give a perspective on the importance of first-principles in the era of AI and ML, as well as showcase real case studies with industrial collaborators that make the value of a hybrid approach apparent. The first case study shows multiple examples of...