Research works

Flexibility of the TRMT10C N-Terminal Domain Helix Explored by Molecular Dynamics Simulations

Abstract The human mitochondrial tRNA methyltransferase TRMT10C contains a 41-residue long positively charged α-helix in its N-terminal domain, interacting with tRNAs from the anticodon to the T-loops. Here, we investigated the flexibility of this N-terminal long α-helix using co...

Multi-factor assessment of future climate hazards to apple production across Switzerland’s growing regions

Abstract Apple production is likely to face increased climate hazards in the future resulting from climate change. The magnitude and relative importance of different climate hazards remain unclear, especially when considering multiple emissions scenarios. Here, we perform a multi...

Valuation of life-insurance contracts with multiple benefits under stochastic mortality: A QP-Rule framework in light of COVID-19

This paper examines the valuation of a life insurance contract combining a Guaranteed Minimum Income Benefit (GMIB), a surrender benefit, and a death benefit under stochastic mortality and financial risks. Building on the established QP-rule valuation approach and a hybrid financ...

MICROLOCAL ANALYSIS, TIME-FREQUENCY TRANSFORMS AND LOCAL UNCERTAINTY PRINCIPLES

In this paper we propose an uncertainty principle of local type involving the short-time Fourier transform in the frame of ultradifferentiable spaces.The classical local uncertainty principle for the Fourier transform can be seen as a refinement of the Heisenberg inequality; the...

1T‐to‐2H Phase Evolution During Epitaxial Growth of Transition Metal Dichalcogenides

ABSTRACT Polymorphism in transition‐metal dichalcogenides is typically defined based on the post‐growth phase (1T or 2H) or stabilized heterophase structures. Transient 1T‐to‐2H phase evolution is demonstrated during epitaxial growth of MoS 2 and WSe 2 on sapphire by metalorganic...

Where is the evidence? A global systematic review of sanitation system resilience to climate hazards

Despite sustained efforts over several decades, no region is projected to achieve universal sanitation access by 2030, according to international monitoring frameworks. Climate change is increasingly disrupting human and ecological systems, in turn deepening existing inequalities...

Counting the costs? The weight of administrative burden in widening participation

Administrative burden theory, emerging from public administration research, centres individuals’ subjective experiences of policy implementation as onerous. Its applicability to higher education (HE) studies, particularly in the United Kingdom , has driven our intellectual curios...

Beyond the locus coeruleus: pupil dynamics as a systems-level marker of neuromodulatory influences on hippocampal memory

Dopamine and norepinephrine regulate hippocampal plasticity through molecular, cellular and circuit mechanisms that shape which experiences are encoded and later remembered. Translating these mechanisms into human memory research remains challenging because direct measures of end...

Young adults’ experiences of using FREED-Mobile, a smartphone friendly intervention designed to facilitate help-seeking for eating disorders

Abstract Background Early intervention increases the likelihood of eating disorder recovery, yet many young people delay seeking professional support for eating difficulties. We developed a smartphone-friendly, online intervention - FREED-Mobile [FREED-M] to encourage early help-...

The energetics of high temperature oxidation and formation mechanisms in binary lanthanide nitrides (LnN)

Abstract Nitride-based materials present exceptional thermal and structural properties for advanced material applications, however accurate determination of their thermodynamic properties is critical to their deployment. Herein, the standard enthalpies of formation, Δ H f ° , for...

One foot after the other – embodied information on the West Highland Way

Purpose Embodied information is posited to be a rich and novel concept with which to explore information behaviour in serious leisure pursuits (Cox et al., 2017). This research uncovers how embodied information is experienced on the West Highland Way (WHW), a long-distance hiking...

A multiomic atlas reveals distinct immune landscapes in preterm and term chronic placental inflammation

Chronic placental inflammation (CPI), an umbrella term encompassing chronic chorioamnionitis, chronic villitis, and chronic deciduitis, is associated with preterm birth (PTB), yet its cellular and molecular determinants across gestation remain poorly defined. Here, we constructed...

Engineered 3D Fibronectin‐Based Environments Modulate the Pathogenic Profile of Arthritic Synovial Fibroblasts

Inflammation is essential for fighting infections and initiating tissue repair, but chronic unresolved inflammation underlies many conditions, like cancer and autoimmune disorders. While dysregulated immune responses drive chronic inflammation, non‐immune stromal cells such as fi...

The Impact of Heterogeneity in Individual Characteristics and Motivation to Quit Heroin Use on Contingency Management and Opioid Agonist Treatment Response: A Latent Class Analysis

ABSTRACT Introduction Contingency Management (CM) involves the systematic application of positive reinforcement (financial incentives) to promote behaviour change, to improve treatment outcomes for individuals with opioid use disorder (OUD). To better understand patient heterogen...

Rod photoreceptors have a dual dependency on both aerobic glycolysis and OXPHOS and diverge metabolically from other retinal neurons

The retina metabolizes glucose into lactate, a hallmark of aerobic glycolysis known as the Warburg effect. Although evidence points to rod photoreceptors as the primary source of aerobic glycolysis, a comparison of the energy metabolism in different retinal neurons has yet to be...

Epistemic violence and academic repression: Anti-Palestinian racism and the politics of knowledge production in the context of the Gaza genocide

This paper critically interrogates the institutionalized repression of pro-Palestinian scholarship in academia, particularly within psychology and allied social sciences, framing it within broader neoliberal and settler-colonial structures. Drawing on postcolonial and decolonial...

NoiBic: a noise-tolerant biclustering algorithm for high-throughput gene expression data analysis

Abstract Motivation High-throughput transcriptomic technologies generate large-scale gene expression datasets for functional module discovery. However, technical and biological noise can obscure coherent expression patterns and compromise module detection. Noise-tolerant methods...

AVERAGE TREATMENT EFFECT LOCALIZATION: PROJECTION METHODS IN SYNTHETIC CONTROL

Many real-world policies and business interventions require assessing short-term effects to inform timely decisions, even though most causal inference methods focus on long-term average treatment effects. In this article, we introduce average treatment effect localization (ATEL),...

Interface-controlled phase stability in polymorphic HfO2 revealed by machine-learning atomistic simulations

HfO 2 exhibits rich polymorphism, and competition among different phases underpins many of its functional properties. Yet bulk free-energy relations alone cannot explain phase selection at mixed-phase boundaries, where interface orientation and structural continuity constrain col...

Dynamics of human cardiogenesis and its disruption in trisomy 21

Abstract Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches 1 . Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a c...