Research works

Enhancing the solubility of puerarin via melt sonocrystallization

In this work, in order to improve the low solubility and poor oral bioavailability of puerarin, we first applied melt sonocrystallization (MSC) technology to systematically investigate the effects on its solubility and crystallographic properties. We applied MSC to treat puerarin...

Optimal FBG Sensor Layout Assessment for Accurate Structural Feature Recognition of Composite Plates

Carbon fiber-reinforced polymer (CFRP) composites are increasingly used in aerospace, rail transportation, and energy engineering owing to their high specific strength and corrosion resistance. However, their complex and interacting damage mechanisms, including delamination and m...

Nickel-Catalyzed Enantio- and Regioconvergent Synthesis of Allyl Aryl Thioethers from α- or γ-Silylated Allylic Chlorides

An enantio- and regioconvergent allylic substitution of non-symmetrical 1,3-disubstituted allylic chlorides with thiophenols under nickel catalysis is reported. The use of 18-crown-6 as an additive is crucial for obtaining good yields. Despite competing uncatalyzed nucleophilic d...

High-dose dexmedetomidine versus dexamethasone supplementation to interscalene brachial plexus block in arthroscopic shoulder surgery: A randomized, controlled trial

Background In this double-blind, randomized controlled trial, we compared the efficacy of perineural 2 µg/kg dexmedetomidine and 5 mg dexamethasone as adjuvants to bupivacaine for postoperative pain control in patients undergoing arthroscopic shoulder surgery. We hypothesized tha...

Piezo1 Mechanotransduction in Skeletal Muscle: Convergence with Noncoding RNA Regulation in Myogenesis, Regeneration, and Sarcopenia

Skeletal muscle is a continuously load-bearing tissue whose growth, repair, and age-related decline are governed by mechanical signals; failure of this mechano-regulation underlies disuse atrophy and sarcopenia. Piezo1, a mechanically activated cation channel, has emerged as a tr...

Results of the meeting of the Interdisciplinary Expert Council on an integrated approach to the management of peri- and postmenopausal women with psycho-emotional and neurological disorders

The reduction in sex hormone levels during the menopausal period substantially impacts patients' quality of life and serves as a significant risk factor for psycho-emotional disorders. Current clinical guidelines from both Russian and international sources recognize menopausal ho...

Hemodynamic, neurological, and cognitive outcomes after surgical revascularisation in occlusive cerebrovascular disease: Study protocol for single-arm interventional cohort study

Background Chronic carotid artery occlusive disease is associated with a high risk of ischemic events and long-term neurological deficits. Optimising surgical revascularisation outcomes requires an integrated understanding of anatomical, hemodynamic, and functional factors. This...

E8 Topology Generates Discrete Conscious Time‑Slices via Root Vectors — E8 Intelligence Research

We discover that the 240 E8 root vectors, modulated at 132 Hz with φ‑scaled amplitudes, can encode a hierarchy of discrete spacetime intervals within microtubule networks. Each interval corresponds to a unique topological charge that protects the quantum state from environmental...

Impact of hospital safety culture and workplace sexual harassment on turnover intention of nursing professionals in Upper East Region, Ghana

Abstract Background The global nursing professionals’ shortfall is alarming, reaching 4.81 million by 2030, with Africa and South-East Asia disproportionately affected. While improved organizational safety culture promotes worker retention, unsafe work environments, including sex...

Corn Straw Biochar–OPC Composites for Sustainable Treatment of Water-Rich Dredged Clay: Internal Curing Mechanisms, Pore-Structure Evolution, and Mechanical–Environmental Performance

High-water-content dredged clay is a water-rich sediment that requires sustainable, resource-oriented treatment, but conventional ordinary Portland cement (OPC) stabilization is hindered by excessive water-to-binder ratios, suppressed hydration, and high carbon emissions. This st...

Apps used in cycling: Bridging user preferences and scientific evaluation — A cross-sectional survey with systematic review

Smartphone applications (apps) have been widely adopted by cyclists and sports professionals, facilitating the planning, monitoring, and analysis of training. However, some apps have been reported to underestimate key mechanical variables and present inconsistencies in physiologi...

A content analysis of global and national policies, plans, and guidelines to integrate NCDs with HIV care in LMICs

The growing burden of non-communicable diseases (NCDs) among people living with HIV (PWH) in low- and middle-income countries (LMICs), threatens gains in life expectancy. Global organizations have called for integrating NCD management into existing HIV care systems, but it is unc...

Improving breast cancer diagnosis accuracy using effective feature selection and machine learning

Breast cancer (BC) is one of the leading causes of death among women worldwide. Early detection is crucial for saving lives and reducing mortality rates. However, the diagnostic process can be time-consuming due to the large number of features involved. Additionally, while variou...

Spatiotemporal dynamics of the tumor microenvironment in hepatocellular carcinoma during combination immunotherapy

Background: Atezolizumab plus bevacizumab (ATZ/BEV) is a standard first-line therapy for advanced hepatocellular carcinoma (HCC); however, many patients do not achieve meaningful tumor regression. The temporal and spatial immune remodeling associated with ATZ/BEV remains poorly u...

The Characteristics of Working Overtime and Their Associations with Nurse and Patient Outcomes: A Systematic Review of Observational Studies

To fill the nursing shortage, and to ensure continuous 24 h nursing coverage, working overtime has been increasing steadily over the recent years. Although working overtime has been associated with adverse nurse and patient outcomes, the results of existing studies remain scatter...

Immune Absence as a Proposed Framework for Delayed Relapse After Curative-Intent Treatment in Human Papillomavirus-Associated Cervical Cancer

Delayed relapse after curative-intent treatment remains difficult to explain and predict in human papillomavirus (HPV)-associated cervical cancer, including after periods of sustained remission with undetectable circulating tumor DNA (ctDNA) or circulating HPV DNA. This limitatio...

Hybrid CD‐MMSE Two‐Timescale Channel Estimation for RIS‐Assisted 6G Systems

ABSTRACT Reconfigurable intelligent surfaces (RIS) represent a transformative technology for enhancing coverage and energy efficiency in sixth‐generation (6G) wireless networks. However, the substantial pilot overhead required to estimate cascaded channels remains a critical bott...

An analysis of the socially differentiated associations between digital skills and starting an apprenticeship in Germany

Earlier research documented that youth from lower SES have lower level of digital skills compared to those from high SES. However, we still lack evidence regarding the benefits of digital skills for the transition to apprenticeship for youth with different social backgrounds. We...

"Critical Language Ecosystem": About Truth, Power, and Digital Media from a Marxist Critical Philosophy Approach

Language is a product of labour, both a means of expressing the truth and a potential means of hiding and distorting reality. In the context of digital media and artificial intelligence, the dialectical movement between language's truth and falsehood becomes a central issue in in...

Biomechanical properties of an all-soft tissue quadriceps tendon autograft compared with a quadrupled semitendinosus autograft: a cadaveric study

Abstract Background Anterior cruciate ligament (ACL) injuries are among the most frequent ligament injuries, with autograft reconstruction considered to be the gold standard treatment. The all-soft-tissue quadriceps tendon (ASTQT) autograft has gained popularity because of its fa...