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South Africa and Qatar in Gaza and Beyond: A New Dawn for Transformative Third-Party Intervention?

As geopolitical realignment intensifies conflict and exposes failures in Western-led intervention, space is opening for alternative actors and approaches. Gaza marks a critical juncture as non-Western third-party actors assume prominent roles, raising questions about their interv...

Accelerometer-measured moderate-to-vigorous physical activity patterns and mortality among individuals with venous thromboembolism: a prospective cohort study from the UK Biobank

Although the “weekend warrior” activity pattern has been associated with lower mortality in the general population, whether it is associated with long-term outcomes after venous thromboembolism (VTE) remains unclear. In this prospective analysis, we examined the association betwe...

HMGA1 and HMGA2: epigenetic regulators in myeloproliferative neoplasms and novel platelet transcriptomic biomarkers of myelofibrosis

We read with great interest two recent studies by Handa et al. [ 1 ] and Bartalucci et al. [ 2 ] reporting novel chromosomal deletions within the 3’ untranslated region (UTR) of HMGA2 (Δ3’ HMGA2 ) in myeloproliferative neoplasms (MPNs). Both teams identified submicroscopic deleti...

Expanding the boundaries of linguistic reasoning in L1 education

Linguistic understanding is increasingly recognized as valuable in L1 education in its own right, not merely as a means to improve literacy. Research on linguistic reasoning, which combines general reasoning skills with subject-specific ways of thinking about language, has begun...

Surgeon task load, ergonomics, and clinical outcomes in laparoscopic versus robotic-assisted inguinal hernia repair: a systematic review and meta-analysis of randomized controlled trials

Abstract Conventional laparoscopic inguinal hernia repair (LIHR) is common and robotic-assisted techniques (RIHR) are increasingly being implemented. Current literature is indecisive on whether RIHR offers clinical and ergonomical benefits. This systematic review compares LIHR an...

Generative AI Literacy and Research Self-Efficacy in Relation to Attitudes Toward Scientific Research Among Health Sciences Students: A Cross-Sectional Study

Generative artificial intelligence (GenAI) has rapidly entered undergraduate research training, yet its relationship with research self-efficacy and attitudes toward scientific research remains underexplored among Health Sciences students. This cross-sectional study examined how...

Nursing under pressure: identity, challenges and coping during pandemic a qualitative study

The COVID-19 pandemic has had a profound impact on the lives of nurses. The increased workload, heightened risk of infection, and experiences of social isolation have significantly affected their physical and psychological well-being. Despite these challenges, nurses have continu...

Semantic indeterminacy in agentic negotiation: agreement after the recession of the principal

Abstract Agentic AI systems increasingly do not merely respond within negotiations but participate in constituting them: they can add issues, instantiate participant agents, and modify procedural rules while an interaction is under way. Human action can be compositionally produce...

Early Adoption and Diffusion of Oral Semaglutide in US Adults With Obesity

This cohort study evaluates early treatment trends of oral semaglutide among adults eligible for obesity management medications following its approval for obesity.

Ultrasound Assessment of Gallbladder Motility After Ingestion of a Bicarbonate-Rich Mineral Water (Aqua 3): A Randomized Crossover Study

Background: Bicarbonate mineral waters have been reported to modulate biliary dynamics. Prior symptom-based data with Aqua 3 suggested digestive benefits, but objective confirmation is still lacking. Aims: We sought to evaluate the effect of Aqua 3 on gallbladder motility in fast...

Unearthing Toxic Beauty: Project CLEAR Protocol to Assess Skin-Lightening Product Exposure in Northern Manhattan

Skin lightening products (SLPs) are widely used among communities of color and often contain toxic chemicals that pose serious health risks. Despite regulations, these products remain accessible in the United States through deceptive labeling and illegal sales, which might contri...

Safeguarding and Valorising European Vegetable Biodiversity Through the Registration of Amateur Varieties: A Critical Analysis

The demand for uniform and high-yielding vegetable varieties has contributed to the erosion of vegetable biodiversity and the marginalisation of locally adapted plant genetic resources (PGR) and landraces that do not meet conventional registration standards. This review criticall...

Comparative policy analysis of urban microplastic pollution and water quality management toward sustainable environmental governance in Malaysian cities

Rapid urbanization in Southeast Asia has intensified microplastic (MP) pollution in city water bodies, urban drainage systems, and coastal environments, posing significant threats to urban water quality and public health. This study employs a comparative policy analysis to evalua...

Leaching, Acute and Chronic Toxicity of Nano-ZnO Incorporated into Photocatalytic Concrete for Pavement Applications Toward Daphnia magna

Urban air pollution has driven the use of photocatalytic concrete for pavement applications, in which nano-ZnO has emerged as an alternative to nano-TiO2. However, its higher solubility raises concerns regarding the release of Zn2+ into the aquatic environment. In this context, t...

Exploring the potential of AI-driven brain–computer interfaces for Alzheimer’s disease: an integrated framework for diagnosis and therapeutic intervention

Early diagnosis and timely intervention are critical in Alzheimer's disease (AD), yet conventional assessments fail to capture longitudinal neural dynamics. Although traditional biomarker frameworks offer essential pathological insights, they remain constrained by high costs and...

Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study

Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...

Outcome heterogeneity in CALR ‐mutated myeloproliferative neoplasms

Summary Calreticulin gene ( CALR ) mutations are seen in 25%–30% of myeloproliferative neoplasms (MPNs). We report outcomes and high‐risk genomic signatures in 149 patients with CALR‐mutated MPN. CALR‐mutated essential thrombocythaemia ( n = 106) progressed to myelofibrosis ( n =...

Impact of blood pressure variability on mortality risk of patients with ANCA-associated vasculitis

Abstract Objectives Antineutrophil cytoplasmic antibody–associated vasculitis (AAV) is associated with increased cardiovascular risk, related to persistent inflammation and endothelial dysfunction. Long -term systolic BP variability (SBPV), reflecting vascular damage, may predict...

Effect of Waste Cooking Oil and Tapioca Starch on Energy Content and Combustion Performance of Coconut Shell-Rice Husk Briquettes

Agricultural waste, such as coconut shells and rice husks, is widely utilized as solid fuel. Tapioca starch serves as the binder, while waste cooking oil (WCO) is used as an additive. Briquette performance is influenced by the type of biomass, binder, and additives used. However,...

Potential utility of more subtle microsatellite instability for predicting response to nivolumab in gastric cancer patients

The relationship between microsatellite instability (MSI) - high (H) and deficient DNA mismatch repair is, in fact, not straightforward. MSI observed in genome-edited cells carrying Lynch syndrome mutations is not so drastic as in typical MSI-H ( i.e. Type B mode) but uniformly m...