Research works

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

Wing Structural Sizing Insights for a Large Battery-Electric Aircraft

Integrating batteries into the wing is a critical design choice in the development of battery-electric aircraft, offering significant benefits for structural weight reduction due to bending relief. To understand the influence of wing-integrated batteries on wing structures, this...

Neurologic Stability During Tafamidis Treatment in Transthyretin Amyloidosis with a Mixed Phenotype: A Multicenter Real-World Study

Real-world evidence on the effect of tafamidis in mixed-phenotype transthyretin (TTR) amyloidosis (ATTR amyloidosis) is limited. This study assessed changes in neurologic and other measures in patients with mixed-phenotype ATTR amyloidosis treated with tafamidis free acid 61 mg f...

Investigation of Multilayer Edible Probiotic Coatings During Refrigerated Storage of Strawberries: A Focus on Lacticaseibacillus casei Shirota and Lacticaseibacillus rhamnosus GG

The layer-by-layer (LBL) coating technique is an emerging alternative to conventional dipping for active packaging, improving coating adhesion to the hydrophilic surface of fruits. This study assessed the effects of probiotic multilayer coatings on microbial quality, physicochemi...

Bilateral Palatal Root Agenesis of Maxillary Fourth Premolars in 2 Welsh Corgis: A Cone Beam Computed Tomography (CBCT)-Based Case Report

Palatal root agenesis of the maxillary fourth premolar (PM4) is a rarely reported developmental anomaly in dogs. This report describes 2 cases of bilateral palatal root agenesis in Welsh Corgis that had complicated crown-root fractures. Initial intraoral radiography suggested abs...

HIV breakthrough infection after 6 years of daily TDF/FTC oral PrEP with objectively documented optimal adherence

Oral Pre-Exposure Prophylaxis (PrEP) is highly effective for HIV prevention when adherence is optimal, with rare HIV breakthrough infections usually happening within 1–2 years since PrEP start. After 6 years of daily PrEP, routine HIV testing identified seroconversion in a 46-yea...

Obstetric intensive care unit admissions and maternal near-miss: insights from a four-year cohort in Turkey

Abstract Background Severe maternal complications requiring intensive care unit (ICU) admission remain important indicators of maternal health, particularly in middle-income settings. This study aimed to evaluate the indications for intensive care unit (ICU) admission, maternal a...

Ce/Mn-MOF with Multiple Enzyme-Mimetic Activities Enables the Alleviation of Plant Saline-Alkali Stress

Abstract Saline-alkali stress impairs plant growth via ROS overaccumulation, while MOF nanozymes offer a promising redox-regulation strategy. In this study, a Ce/Mn-MOF nanozyme was synthesized via a solvothermal method through a bimetallic doping strategy. The reversible valence...

Umbilical cord red blood cell transfusions in very premature neonates: A physiologically aligned transfusion strategy

The authors have disclosed no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Vasoepididymostomy‐First Versus Primary ICSI for Epididymal Obstructive Azoospermia: Real‐World Reproductive Outcomes for Treatment Selection

ABSTRACT Background In couples with epididymal obstructive azoospermia (EOA), choosing between microsurgical vasoepididymostomy (MVE)‐first and primary intracytoplasmic sperm injection (ICSI) remains a practical treatment‐selection challenge. Conventional endpoints such as patenc...

Orthopaedic Management of Bone Metastases from Lung Cancer

Background/Objectives: Bone metastases from lung cancer can cause pain, pathological fracture, spinal instability, metastatic spinal cord compression and loss of independence. Lung cancer-specific evidence for orthopaedically relevant local management remains fragmented. This rev...

Analysis of Human Factors and Engineering Design Contributions to Aerospace Incidents

This study investigates the factors influencing aviation incident outcomes, with a focus on distinguishing between crash events and emergency landings. A curated dataset of 53 aviation incidents was analyzed using logistic regression and machine learning classifiers to identify t...

DNA nanodevice-engineered macrophages as living sensors for dual-mode in vivo monitoring of tumor-associated macrophage polarization

Exploiting macrophages as cell-autonomous reporters of their polarization states represents a promising strategy for interrogating tumor-associated macrophage (TAM) phenotypes in cancer. Here, we develop a macrophage-based sensing platform, termed eMφ. This platform is created by...

Estimation of Individual-Tree Volume in Subtropical Plantation Forests Based on Ultra-High Density Unmanned Aerial Laser Radar

Understanding current forest resource status is fundamental for formulating forestry policies and management plans. 3D laser scanning provides an effective approach for conducting forest resource surveys efficiently and accurately, which is the core background and aim of this stu...

Projected country-level health effects and service requirements of Helicobacter pylori screen-and-treat and targeted endoscopic screening, 2025–2050: a comparative modelling study

Helicobacter pylori eradication reduces gastric cancer incidence. We compared improvements in testing, treatment and endoscopic screening to identify their projected health gains and service requirements. We combined Global Burden of Disease 2023 estimates, population projections...

Sleep Healthy Using the Internet: A Meta-Analysis of Twenty Years of Research on a Digital Cognitive Behavioral Therapy for Insomnia Program

Abstract Study Objectives To summarize two decades of research on Sleep Healthy Using the Internet (SHUTi), among the most-studied digital Cognitive Behavioral Therapy for Insomnia programs. Methods PubMed, CINAHL, Web of Science, and PsycINFO were comprehensively searched throug...

From Flower Micelles to Flower Necklaces: Self-Assembly of Dodecyl Succinate−Modified Pullulan in Aqueous Solution

Abstract Fourteen pullulan derivatives bearing dodecyl succinate side chains (PulDDS) were synthesized from seven parent pullulan samples covering wide ranges of weight-average molar mass (Mw) and degree of substitution (DS). Their micellar structures in 25 mM aqueous NaCl were c...

A Proposed Convergent Genetic and Molecular Framework for Legg–Calvé–Perthes Disease: A Scoping Review

Legg–Calvé–Perthes disease (LCPD) is a rare pediatric disorder characterized by avascular osteonecrosis of the femoral head. Its pathogenesis is multifactorial, and genetic, epigenetic, vascular, and inflammatory mechanisms may contribute to disease susceptibility and progression...

Effects of Anticoagulant Rodenticides and Farm Habitat Structure on Avian Communities in Livestock Farms

Rat control using anticoagulant rodenticides on livestock farms is a widely applied practice worldwide. Birds can be exposed to rodenticides through direct ingestion or secondary poisoning, resulting in mortality or sublethal health effects. While impacts on raptors and owls are...

Multiscale axial displacement measurement based on radially segmented double-helix PSF and multi-feature hierarchical demodulation

The double-helix point spread function (DH-PSF) inherently suffers from a trade-off between axial range and sensitivity, which limits its use in optical alignment and focal-plane tracking tasks that require both wide-range acquisition and high-precision localization. To overcome...