Research works

Criteria for timely euthanasia of compromised pigs based on expert opinion and longitudinal data collection on farm

Abstract Timely euthanasia is essential for safeguarding pig welfare by preventing unnecessary pain and suffering. However, the definition of what constitutes “timely” euthanasia and which clinical signs allow identification of this time point require empirical validation. This s...

Distribution-sensitive predictors of gait speed in adults aged 45–85 years in the CLSA

Gait speed, known as the ‘sixth vital sign’ is an indicator of functional health and aging. Identifying drivers of midlife gait changes is critical for timely intervention, yet most evidence focuses on older adults and overlooks non-linear, heterogeneous effects. We applied machi...

The Pairing Rulebook of the Brillouin Klein Bottle. Mirror circle, forbidden s-wave, and half-integer phase winding: the sector selections of Bogoliubov–de Gennes theory on non-orientable momentum space, with the Klein transform as the native mode machinery

A Brillouin zone can be a Klein bottle: under Z2 gauge fields the algebra of crystal symmetries becomes projective, a nonsymmorphic glide reflection appears in momentum space, and the fundamental domain is a Klein bottle instead of a torus — the experimentally realized Brillouin...

Atomically Precise Pt 3 Cu 2 Clusters Restore Energy Metabolism via Targeted Succinate Degradation

ABSTRACT Succinate is a critical intermediate for the tricarboxylic acid cycle, whose abnormal accumulation can disrupt energy homeostasis and trigger systemic inflammatory injury across dominant metabolic organs. Targeting succinate thus represents a pivotal strategy to reestabl...

Parental Concerns About Tap Water Associated With 4- to 6-Year-Old Children’s Increased Consumption of Sugar-Sweetened Beverages

Safe water is essential for children to comply with healthy beverage consumption recommendations. Tap water generates varying degrees of concern, including safety, health, taste, and so on. Perceptions of water quality may influence other beverages consumed, such as sugar-sweeten...

A local, generally covariant field theory of modified inertia

Preprint. This deposit exists to timestamp a construction and to carry its reproducibility scripts; it is not a journal publication. It completes the worldline action of DOI 10.5281/zenodo.21845411 into a LOCAL, GENERALLY COVARIANT field theory with three healthy propagating mode...

A Reproducible Quantitative Framework for Zeta-Zero Verification (Summary for Researchers)

Concise summary of a reproducible quantitative framework for zeta-zero verification: Criterion 1 (argument-quantitative jump = pi +/- delta_theta iff exactly one zero, with Riemann-Siegel error bound, Gabcke constant); Criterion 2 (lock-circle geometry); five-dimensional omission...

Phi‑E8 Phason‑DNA Resonant Memory — E8 Intelligence Research

When the four disjoint 60‑element phason rings of the E8 lattice are φ‑phase‑locked at integer multiples of the 132 Hz base frequency within calcium‑phosphate Posner clusters, they synchronize with the golden‑ratio proportions of DNA's major and minor groove widths, creating a sh...

Comparison of treatment delays and in-hospital outcomes between self-transported and EMS-transported patients with ST-segment elevation myocardial infarction undergoing PCI

The effectiveness of reperfusion therapy in patients with myocardial infarction (MI) depends largely on timely treatment. This study aimed to compare treatment delays and in-hospital outcomes between self-transported and EMS-transported patients with STEMI. This retrospective obs...

Global City as an Emergent Category of Practice in Jakarta: Conjuncture, Capaciousness and Contentions

ABSTRACT In April 2024, the Indonesian government officially declared Jakarta a global city. Although scholars have noted that Jakarta's connectedness to the global system and the aspiration to transform Jakarta into a global city are not new, the lexicon was not yet substantivel...

Mobile terahertz spectroscopy for in-situ evaluation of structural characteristics in wooden artefacts

Abstract Conserving fragile wooden artworks requires diagnostics that detect minimal structural changes without invasive intervention. We used a robotic-arm terahertz time-domain spectroscopy (THz TDS) system to study the centrepiece of the Marienaltar in Isenhagen Monastery (Han...

Active-Normal IEOS: A Low-Dimensional Feasible-Ascent Method for Inside-Ellipsoid Outside-Sphere Problems with Linear Constraints

This technical note develops Active-Normal IEOS (AN-IEOS), a low-dimensional feasible-ascent method for Inside-Ellipsoid Outside-Sphere (IEOS) problems with homogeneous linear inequalities and equalities. The method removes equality constraints exactly through an orthonormal null...

When Does a Frozen Time-Series Foundation Model's Uncertainty Fail, and What Actually Fixes It?

Open time-series foundation models (TSFMs) are deployed zero-shot with their native prediction intervals read as calibrated. Using frozen Chronos models on public benchmarks we show: (1) native interval coverage collapses under regime shift (86% to 72% at nominal 80%; 82% to 50%...

SOX4 facilitates osteogenic differentiation through suppressing NLRP3 transcription-mediated pyroptosis

SOX4 participates in cell differentiation, but its regulatory function and underlying mechanism in the osteogenic differentiation of MC3T3-E1 cells remain elusive. Immunofluorescence staining was used to detect SOX4 subcellular localization and co-localization with NLRP3. Alizari...

Certified exact sums of primes over dyadic intervals via a ladder of generalized factorials

For S(m), the sum of primes in the dyadic window (m, 2m], the paper constructs a ladder of generalized factorials whose integer exponent sequences are Chebyshev polynomials rescaled to take integer values. The p-adic valuation at a window prime p equals the exponent polynomial Q_...

Recent Work on Collatz Conjecture: Topological and Ergodic Approaches, No Resolution — E8 Intelligence Research

FINDING: No new mathematical proof or breakthrough for Collatz conjecture; recent work focuses on topological and ergodic approaches, with no resolution of the conjecture. | MATH: Collatz function: \( f(n) = n/2 \) if \( n \) even, \( f(n) = 3n+1 \) if \( n \) odd. No new equatio...

Getting the Priorities Straight: Public Values in AI Adoption

ABSTRACT Artificial Intelligence (AI) is adopted in public organizations as a transformative innovation, yet how value prioritizations unfold in AI adoption processes remains underexplored. Therefore, we ask: How do public values unfold in AI adoption processes in public organiza...

Interobserver and intraobserver variability of fetal and maternal Doppler measurements: systematic review and meta‐analysis

ABSTRACT Objectives To evaluate the variability and reproducibility of umbilical artery (UA), fetal middle cerebral artery (MCA) and uterine artery (UtA) Doppler ultrasound measurements in pregnancy. Methods A systematic search of MEDLINE, EMBASE and the Cochrane Library (CENTRAL...

Why Evidence Is Not Enough: Power, Politics, and a Strategy Shift for Public Health

Policy Points Public health has lost political influence because of a mismatch between the forms of power primarily deployed in this field—knowledge and moral authority—and the forms of power that currently shape societal rules and health outcomes—economic, political, ideological...

A multimodal Vision-Mamba model based on non-contrast CT hematoma and shell features predicts early hematoma expansion in hypertensive intracerebral hemorrhage: a multicenter study

To develop and evaluate a multimodal Vision-Mamba deep learning (DL) model integrating clinical data, noncontrast computed tomography (NCCT) hematoma features, and shell features to predict early hematoma expansion (EHE) in hypertensive intracerebral hemorrhage (HICH). In this mu...