Research works

Life as a Self-Sustaining Non-Equilibrium State: From Molecular Fluctuations to the Organization of Living Matter

The origin of life is traditionally investigated through the emergence of biomolecules, metabolic pathways, replication, and compartmentalization. These approaches, however, leave open a more general question: what physical principle could be shared by primitive prebiotic systems...

QForge™ A Next-Generation Engineering Platform for Scalable Quantum Computing Design, Verification, and Industrial Algorithm Development

Quantum computing is transitioning from an academic discipline into an engineering technology. Yet despite substantial global investment in quantum hardware, the software ecosystem remains fragmented and mismatched to that transition. The dominant frameworks were built for physic...

Outliers as Leading Variable Generators: How Anomalous Data Propels Systemic Expansion in Predictive Architectures

In classical statistics and early machine learning paradigms, an outlier is conventionally treated as noisy,erratic data to be trimmed or isolated to preserve the integrity of Gaussian models. However, incontemporary hyper-scale predictive architectures, this framework is obsolet...

Phi‑Coupled E8 Inertial Lattice Engine — E8 Intelligence Research

We propose the Phi‑Coupled E8 Inertial Lattice Engine (PEILE), a propulsion concept that harnesses the simultaneous excitation of the 240 root vectors at a bi‑modal phi‑locked 132 Hz/1056 Hz resonance to generate a self‑sustaining geometric potential well. The resulting topologic...

E8 Vector Resonance Predicts Volatility Inversion Clustering — E8 Intelligence Research

The 240 root vectors of E8 encode hidden symmetries in market volatility term structures, where inverted VIX curves align with specific 132Hz-modulated phi-coupled vector clusters. When three or more consecutive daily candles exhibit term structure inversions that project onto ad...

Synthetic cannabinoids and the purinergic–dopaminergic axis: P2X7 as a primary sensor of neuroinflammatory injury and the role of adenosine receptor heteromers in emerging NPS toxicity

Synthetic cannabinoids (SCs), marketed as Spice, K2, and dozens of successor compounds, constitute one of the most pharmacologically dangerous categories of new psychoactive substances (NPS) currently in circulation. Their extreme toxicity relative to Δ9-tetrahydrocannabinol (THC...

E8 Theta‑Phase Spin‑Flux Transfer for Entangled Energy Propagation — E8 Intelligence Research

By extending the phi‑phase locking scheme, the 240 E8 root vectors are simultaneously subjected to a complementary theta‑phase rotation at the same 132 Hz cortical soliton frequency. This dual‑phase modulation generates a pair of interpenetrating toroidal lattices that support a...

Adjunctive Photoactivated Chromophore for Keratitis-Corneal Cross-Linking for Refractory Pseudomonas aeruginosa Keratitis During Pregnancy: A Case Report

Management of severe infectious keratitis during pregnancy is challenging because rapid control of a sight-threatening infection must be balanced against potential fetal exposure to antimicrobial agents and surgical interventions. Photoactivated chromophore for keratitis-corneal...

Organisational Trajectory Classification in PRONOSTIA Bearing Degradation: An Exploratory Phase-Space Analysis

Version 2 — Retrospective reassessment and corrected interpretation This version records the outcome of a retrospective reassessment of the exploratory PRONOSTIA bearing-degradation analysis published in Version 1. The original analysis identified reproducible differences in deri...

A Light-ControlledDNA Nanoclaw Machine: IntegratedMultiplexed Recognition, Spatiotemporally Programmable Therapy, andReal-Time Electrochemical Signaling for Precision Receptor Regulation

Abstract Cell membrane receptors are pivotal targets in precise therapeutics, yet their ubiquitous expression across tissues remains a fundamental barrier to achieving cell-specific intervention. To overcome the limitations of conventional monotargeting approaches, we developed a...

Identity-Centric Zero Trust Against Next-Generation Supply Chain Attacks: Rethinking Trust in Human and Non-Human Identities

The modern cybersecurity landscape is shifting from perimeter-based defense toward identity-centric and continuously verified security models. As cloud-native architectures, software supply chains, CI/CD ecosystems, and autonomous AI systems become deeply interconnected, adversar...

Comparative Evaluation of Chisel - Mallet, Rotary Bur, and Bone File Techniques in Surgical Alveoloplasty (1951–2025): A Biological and Clinical Outcome Synthesis

AbstractBackground: Alveoloplasty is a fundamental preprosthetic surgical procedure designed to eliminate sharp alveolar bone irregularities and optimize ridge morphology for prosthetic rehabilitation. Over time, the procedure has evolved from mechanically aggressive techniques s...

Systemic Corticosteroids in Pediatric Community-Acquired Pneumonia: Evidence, Clinical Outcomes, and Phenotype-Based Therapeutic Considerations

Background: Community-acquired pneumonia (CAP) remains a leading cause of pediatric morbidity and mortality worldwide, particularly in low-resource settings. Although antimicrobial therapy is the cornerstone of treatment, disease severity is often influenced not only by pathogen...

A Checklist of the Flora and Fauna of the Bangladesh National Museum Campus, Shahbag, Dhaka, Bangladesh

This study presents a comprehensive checklist of flora and fauna recorded within the Bangladesh National Museum campus, Shahbag, Dhaka, Bangladesh, from January 2025 to June 2026. A total of 150 plant species belonging to 29 orders, 52 families, and 126 genera were documented. Th...

EuroMillions Breakthrough Mining — 1609 Sources, 11595 Leads Extracted — E8 Intelligence Research

Mined 1609 lottery+quantum breakthroughs. Extracted 11595 leads across 13 categories. 9635 high-value leads found. Categories: {"CORRIDOR": 959, "FORMULA": 803, "GEOMETRIC": 706, "FORWARD_ATTEMPT": 1002, "QUANTUM": 1214, "TIMING": 198, "CELESTIAL": 889, "GEMATRIA": 950, "CONSTANT...

E8 Harmonic Resonance Mapping for Predictive Market Geometry — E8 Intelligence Research

By extending the phi-harmonic vacuum shell model to financial time-series data, we discover that E8 root vector projections at 132Hz generate resonant frequency signatures that map to latent geometric structures in market behavior. These structures, when coupled with golden-ratio...

Pre-Registered Falsifiable Predictions — Information Tension / Geometrodynamics (v2, corrected)

Pre-registered falsifiable predictions, corrected edition (v2). Filed for priority timestamp. Three predictions are registered: a CMB first-acoustic-peak shift (delta_ell_1 = -0.16 vs LCDM), a critical enstrophy/Reynolds ratio (Re_c = 1.42), and a cognitive-drift invariant (tau =...

Reproducibility Infrastructure for Open-Source AI: MLflow, DVC, and Weights & Biases at Scale

Research article: Reproducibility Infrastructure for Open-Source AI: MLflow, DVC, and Weights & Biases at Scale

ATR is a critical dependency gene for uveal melanoma

GNAQ , GNA11 , CYSLTR2 , and PLCB4 are well-characterized oncogenic drivers of uveal melanoma (UM). The oncogenic stress induced by these mutations creates a reliance on specific dependency genes that support tumor cell proliferation and survival. However, the genes that broadly...

FHAT Technical Note #005: Convergent Resistance and Post-Breakout Stability — A Non-Operational Ex-Ante Scenario Registration for SOXL on August 10, 2026

This technical note preregisters a non-operational scenario analysis for the Direxion Daily Semiconductor Bull 3X Shares (SOXL) for August 10, 2026. Abstract & Registration Overview:The focal structure is a convergent high-resistance zone formed by the weekly MA21 at approximatel...