Research works

Prospective multicenter study on patient-related outcomes of orbital floor reconstruction using ultrahigh-molecular-weight polyethylene

This prospective, multicenter clinical study evaluated patient-reported outcomes, functional recovery, and quality of life following orbital floor reconstruction using ultra-high-molecular-weight-polyethylene (UHMWPE) implants. The study emphasized both subjective recovery and th...

Atemporal Topological Information Dynamics: Emergence of Time via Categorical Amnesia and Non-Hermitian Friction (Part 1/Draft)

To resolve the 'Problem of Time'—a foundational challenge in quantum gravity and open quantum systems—this paper proposes Atemporal Topological Information Dynamics (ATID), a novel information-theoretic framework that operates without a background spacetime manifold. We formulate...

Stent-Graft Fracture 18 Years After Hybrid Repair of Thoracoabdominal Aortic Aneurysm: A Possible Risk of Retrograde Reconstruction

We report the case of a patient who underwent hybrid repair for a type V thoracoabdominal aortic aneurysm. The procedure ensured durable aneurysm exclusion and visceral perfusion for 18 years. Eighteen years after surgery, the stent-graft fractured occurred at the visceral artery...

Residential proximity to intensive animal agriculture associates with increased prevalence of antimicrobial resistance in homes

BACKGROUND: Antimicrobial resistance (AMR), a global public health threat, affects rural communities disproportionately due to their unique regional exposures, including proximity to animal feeding operations (AFOs), a source of AMR genes. OBJECTIVE: We evaluated residential prox...

Open-label Phase 1 study to evaluate drug-drug interactions between ulonivirine and islatravir in adults without HIV

ABSTRACT Ulonivirine is a non-nucleoside reverse transcriptase inhibitor in clinical development for once-weekly oral treatment of HIV-1 in combination with islatravir. This open-label, 3-period, Phase 1 study (MK-8507-016, NCT06619678) in adults without HIV evaluated the potenti...

Changing Prescription Patterns in Pharmacologically Treated Patients with Newly Diagnosed Inflammatory Bowel Disease in German Gastroenterology Practices: A Real-World Study, 2015–2024

Background/Objectives: The therapeutic landscape of inflammatory bowel disease (IBD) has evolved, particularly with the expanding availability of biologic and targeted therapies. This study characterized real-world prescribing patterns among patients with newly diagnosed Crohn’s...

Transformational leadership and organizational culture as predictors of employee resilience: the moderating role of AI control in IT firms

Purpose This study aims to investigate the relationship between employee resilience in the IT industry and the effects of transformational leadership and organizational culture, as well as the moderating effect of AI control systems in the relationships mentioned above. The objec...

E8 Octonionic Chirality-Vortex Resonant Cascade Threshold (OCVRCT) — E8 Intelligence Research

Building on OCRPLT's chirality-gated phase-lock condition, we identify OCVRCT: when two counter-rotating octonionic fields satisfy the harmonic ratio φⁿ/φ⁻ⁿ across three successive E8 root-vector nodes (a 720° cascade), their conjugate chirality states collapse into a single self...

Flexible Day-Ahead Scheduling of a Cascade Hydro-Wind-Solar-Thermal-Storage System Including Hybrid Pumped Storage

To advance the modernization of power systems, the role of hydropower has transitioned from mere energy generation to serving as both a primary energy provider and a critical flexibility resource. However, conventional day-ahead scheduling methodologies for cascaded hydropower of...

Modern Design Principles of Fluxgate Magnetometers

This review analyzes recent advances in fluxgate magnetometers. It introduces an innovative concept of using magnetically ordered composite and crystalline structures made of ferrites or conducting ferromagnetic materials as fluxgate cores. These active physical media enable new...

MSP² Generator Table: The 3x−1 Mirror System, Coverage Mechanisms, and Exceptional Cycles

This research note by Mario Sousa Pereira and Enzo Mazzoni extends the study of the MSP² Generator Table to the mirror system defined by 3x−1, in comparison with the classical Syracuse (3x+1) system. The document examines how changing the sign affects the recursive construction o...

Performance Assessment of Centrifugation-Based Hematocrit Testing in Primary Care Units: Evidence from Seventy-Two Proficiency Testing Datasets over Eight Years

Background: Centrifugation-based hematocrit (Hct) testing remains widely used in decentralized primary care settings where access to automated hematology analyzers may be limited. Appropriate proficiency testing (PT) performance assessment therefore requires consideration of the...

Vaginal and urinary microbiota in breast cancer survivors undergoing fractional CO2 laser therapy

Abstract Genitourinary syndrome of menopause (GSM) is common in breast cancer survivors (BCSs) receiving endocrine therapy, and non-hormonal treatment options remain limited. Fractional CO₂ laser therapy has been investigated as a non-hormonal treatment option, but its influence...

A Method for Relatively Accurate Quantitative Calculation of the Motion Decoupling Performance of Parallel Mechanisms

Abstract Excellent motion decoupling performance (MDP) of parallel mechanisms (PMs) will give them significant advantages in kinematics/dynamics modeling, real-time control, and other aspects. However, current methods for evaluating the MDP of PMs remain at a qualitative level. T...

Efficient Photocatalytic H2O2 Formation by a Porphyrin-TiO2 Hybrid Catalyst in Pure Water

Abstract Efficient production of hydrogen peroxide (H2O2) has attracted much interest because of the growing importance of H2O2 as an energy source. In this study, we have developed photocatalytic H2O2 production in ultrapure water catalyzed by an organic–inorganic hybrid photoca...

Comparative evaluation of linear and nonlinear dimensionality reduction techniques for breast cancer diagnosis

Abstract Dimensionality reduction plays a crucial role in improving the interpretability and structural visualization of machine learning configurations applied to high-dimensional biomedical data. This study presents an exploratory comparative evaluation of four widely used tech...

Exact Soliton Solutions and Lyapunov-Based Nonlinear Dynamical Analysis of a Classical Kolmogorov–Petrovsky–Piskunov Equation

In this study, an analytical and dynamical study of the classical Kolmogorov–Petrovsky– Piskunov (KPP) equation is carried out by means of the improved generalized Riccati equation mapping (IGREM) method. An appropriate traveling-wave transformation is used to reduce the governin...

Controlled Ring-Opening Polymerization of 5-Phenyl-1,4-dioxan-2-one toward Stereochemically Tunable and Closed-Loop Recyclable Polyesters

Abstract The practical applications of closed-loop recyclable polymers demand monomers that are readily accessible from simple feedstocks while enabling controlled polymerization and tunable physical properties. Herein, we report a one-pot synthesis of 5-phenyl-1,4-dioxan-2-one (...

Effect of Age on Physical Function Improvement in Older Veterans Enrolled in the Gerofit Exercise Program

Background/Objectives: Aging is associated with declines in strength, balance, and mobility that contribute to falls, disability, and loss of independence. While exercise interventions improve physical function, limited data exist on community-dwelling adults aged 90 years and ol...

Domestic chlorine gas exposures from household product mixing in France: characteristics, severity, and temporal trends, 2010–2025

Abstract Background Domestic chlorine gas exposures, resulting from the mixing of hypochlorite-based products with acidic products, are a recognised public health issue. However, national evidence on factors associated with severity and long-term trends remains limited. We aimed...