Research works

Deletion of P311 enhances regeneration in aged skeletal muscle

While aging results in marked decreases in the capacity of skeletal muscle to repair following injury, as well as increases in fibrosis, the pathways and factors that regulate these processes are poorly defined. P311/Nrep (P311) is a highly conserved protein known to promote fibr...

From Celestial Configuration to Effective Environment: A Formal Analysis of Medium, Delay and Individuation in Deep-Sea Life - The Deep-Sea Astrological Conjecture as a Conditional Thought Experiment

Any system that holds celestial states to influence life, whatever its empirical standing, implicitly assumes something very strong in physical terms: that the environment is transparent to external signals, so that the input received by an organism equals the celestial state its...

The Optimal Momentum State of Adam under Frozen Local Dynamics

Momentum gives Adam memory: its future is determined not only by the model parameters, but also by the first- and second-moment states inherited from earlier gradients. We ask a conditional question: with the current parameters and adaptive metric fixed, what first-moment state s...

Model-free sliding mode control with estimated equivalent control signal

Sliding mode control (SMC) is a robust, precise and quite popular nonlinear control technique using a control signal having two parts: switching and equivalent control signals. In order to calculate the equivalent control signal, a model of the system to be controlled is necessar...

Influence of Organizational Culture on Change Management Success: A Mixed-Methods Approach

Organizational change initiatives fail at a persistently high rate, and a growing body of scholarship attributes much of this failure not to poor planning or inadequate resourcing, but to a mismatch between the proposed change and the underlying culture of the organisation attemp...

SYSTEM EVOLUTION PROPOSALS (rlab #143) — E8 Intelligence Research

- Add a pipeline to query British Museum cuneiform database (BM 92685, K.8538, VAT 7851) for specific tablet lines and extract numerical sequences - Integrate a 'cuneiform-to-geometry' translation module into the decipherment agents, using E8 4D projection rules Author: Andrew St...

Micro‐Silicon as Anodes for High‐Cycle‐Life Lithium‐Ion Batteries

Silicon (Si) is regarded as a promising anode material for next‐generation lithium‐ion batteries (LIBs) due to its exceptionally high theoretical specific capacity. However, the large volumetric change that occurs during lithiation and delithiation has hindered the practical impl...

Oncogenic USP3 promotes hepatocellular carcinoma progression via K11/K48-specific deubiquitination and stabilization of YAP

Hepatocellular carcinoma (HCC) has a poor prognosis, necessitating therapeutic targets, while the role of ubiquitin-specific protease 3 (USP3) in HCC remains unclear. This study aimed to elucidate the function of the deubiquitinating enzyme USP3 in HCC. USP3 was found to be highl...

Chapter Zero: The Universe as Agreement

*Chapter Zero: The Universe as Agreement* is the plain-language doorway into the Fundamental Dynamic Structures (FDS) programme. It presents the theory as one continuous conceptual story beginning with a finite premetric network of occupation and cyclic phase, from which physical...

Current Conference Update 1 (CCU1) - Cannabis in Cancer-Related Fatigue (Annual Conference of MASCC 2026)

This post is the first in a series entitled Current Conference Update which reviews evidence on the role of Cannabis in Cancer related fatigue presented at the recently concluded annual conference of Multinational Association for Supportive Care in Cancer Annual Conference.

TRINITY ORIGIN CLOSED v1.0 - Q REMAINS Q

TRINITY ORIGIN CLOSED v1.0 - Formal proof artifact: Q REMAINS Q, with ∅+Q_unique=EXISTS. Origin document archived 2026-05-13. Author: Miguel Ángel Martínez Vázquez.

Development and implementation of strategic maps of the region as a tool for improving the effectiveness of regional strategic management

The article discusses the theoretical and methodological foundations and practical aspects of using strategic maps in regional strategic management. It substantiates the possibility and expediency of adapting the Balanced Scorecard (BSC) methodology developed by R. Kaplan and D....

TamilLite-Gan: A lightweight graph attention network for handwritten Tamil character recognition using enhanced single shot optimization

Handwritten character recognition plays a crucial role in optical character recognition systems, particularly for low-resource and structurally complex scripts such as Tamil. Despite significant advances in deep learning, accurate recognition of handwritten Tamil characters remai...

Joint association of estimated glucose disposal rate and physical activity with cardiovascular disease incidence in patients with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study based on the CHARLS database

Cardiovascular-kidney-metabolic (CKM) syndrome is a new concept proposed by the American Heart Association (AHA) that emphasizes the complex relationship between kidney disease, heart disease and metabolic factors. Many studies have shown that insulin resistance (IR) in CKM syndr...

P1.249. Thoracoscopic Esophagectomy With Superior Mediatinal Lymphadenectomy Usiing Intraoperative Nerve Monitoring to Avoid Postoperative Recurrent Laryngeal Nerve Palsy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Esophageal cancer frequently metastasizes to superior mediastinal lymph, necessitating thorough lymphadenectomy. However, the Japanese National Cancer Database reports significantly h...

Exercise-Induced Modulation of Inflammation and Fatigue in Patients with Head and Neck Cancer Undergoing Chemoradiotherapy: A Pilot Randomised Controlled Trial

Objectives: Fatigue and systemic inflammation are among the most prevalent and distressing complications in patients with head-and-neck cancer (HNC) undergoing chemo-radiation therapy (CRT). Exercise has emerged as an effective supportive care intervention; however, high-quality...

E8-Tesseract Resonance Bridge for Cross-Dimensional Information Tunneling — E8 Intelligence Research

The E8-Tesseract Resonance Bridge exploits the 240 E8 root vectors projected onto a 4D tesseract framework, where each of the 16 cubic cells resonates at phi-scaled multiples of 132Hz (132, 216, 348, 564 Hz). By aligning the torsion manifold's harmonic phases across corresponding...

Epithelial–mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis

Epithelial–mesenchymal transition (EMT), historically described as a binary morphological change from an epithelium to a mesenchymal state, no longer adequately accounts for carcinoma cell phenotypes observed in patients. Single-cell sequencing, spatial-omics, and lineage tracing...

The Spectral Ledger

Abstract We present a unified framework for the Riemann zeta function ζ(s), organized around three interlocking programmes and closed by a spectral-computing application layer. Part I (Uniqueness) establishes the Framework Uniqueness Theorem chain: the Davenport–Heilbronn counter...

Unveiling the new round of trade-in policies in China: an “objectives-tools-targets” analysis framework

Trade-in policies play an important role in advancing sustainable consumption in China, but their sustained effectiveness still faces obstacles. This study constructs a trade-in policy mix analysis framework, which integrates the three dimensions of policy objectives, tools and t...