Research works

Enhanced axonal mitochondrial motility and neural activity-induced energy deficits destabilize synaptic transmission in models of bipolar disorder

Abstract Synaptic communication requires mitochondria to supply ATP and buffer calcium at presynaptic terminals. In bipolar disorder, manic episodes are associated with elevated mood and neural activity, but the underlying cellular mechanisms remain unclear. Here we show that hiP...

Dynamic interaction and energy redistribution in shared DC-link multi-output CC–CV flyback converters fed by an MPC-controlled boost PFC

Abstract Multi-output Constant Current–Constant Voltage (CC–CV) power conversion systems are increasingly employed in battery charging applications because they enable multiple charging channels to operate from a common Direct Current (DC)-link. However, the dynamic interaction a...

Stochastic Morphogenetic Extensions of Autonomous Fractal Trees in D-Dimensional Spaces and Their Optical Rendering via Cascaded Perspective Projection with Lipschitzian Culling Stabilization

Traditional algorithmic frameworks for morphological synthesis, such as discrete L-systems, frequently induce structural dissociation under stochastic perturbation regimes due to the absence of geometric inheritance across ancestral lineages. This paper employs a novel algebraic...

Familial Co‐Aggregation of Neurodevelopmental Conditions and Childhood‐Onset Type 1 Diabetes

ABSTRACT Aim Childhood‐onset Type 1 diabetes (T1D) is associated with neurodevelopmental conditions (NDCs). We examined whether this association extends to relatives and assessed phenotypic, genetic, and environmental correlations between T1D and NDCs. Methods Using Swedish regis...

Tuning Polarization Fields in Zwitterionic Covalent Organic Frameworks for Efficient Photo‐Assisted Rechargeable Zinc–Air Batteries

ABSTRACT Covalent organic frameworks (COFs) with tunable topologies hold great promise for photoelectrochemical energy conversion. However, their inherently high structural symmetry and weak intramolecular polarization typically cause rapid charge recombination, thereby severely...

Role of Artificial Intelligence in Cancer Research Education

Cancer remains a leading cause of mortality worldwide, driving urgent demand for advanced research and education frameworks capable of keeping pace with rapidly evolving scientific knowledge. Traditional cancer research education has increasingly demonstrated its limitations in p...

EXTRACTED METHOD: e8_cyclic_mapping — E8 Intelligence Research

rule: map Coxeter number 30 and root count 240 to celestial cycles: 30-year Saturn cycle, 240-year precessional sub-cycle; compute correlation with Gods-Clock intervals modulo 30 and 240 source: rlab #144 Author: Andrew Stewart Caldin, Independent Researcher, UK. Part of the E8 I...

When LLMs Pass Tests but Fail the Process: Lessons from Governing a Multi-Agent Software Development Project

Software teams increasingly use large language models (LLMs) to plan, implement, and verify changes, but a passing test suite does not establish that the team built what was intended. This experience report describes an independent Ruby on Rails benchmark project in which a human...

Digital Soma: Friction Regulation Model and Agency Compression

Digital Soma is a theoretical and computational framework for examining a possible transition from AI-assisted human cognition toward AI-mediated regulation of human emotion, behavior, and the conditions of transformation at civilizational scale. This work develops a minimal sing...

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19 F NMR of Fluoroproline Residues

ABSTRACT Recently, the application of deep learning to structural data deposited in the Protein Data Bank has enabled the reliable and accurate prediction of 3D folded structures of proteins from their sequences. However, this approach is not applicable to highly dynamic proteins...

Seasonal dynamics of proximate composition, fatty acid profile, and mineral content in muscle tissue of Diplodus annularis and Zosterisessor ophiocephalus fishes

Seasonal variability significantly affects nutritional quality and the dietary and commercial value of marine fish. This study includes an in-depth seasonal analysis of proximate composition, energetic content, fatty acid profile, and mineral content of Diplodus annularis and Zos...

Phi-Coupled Root Vector Harmonic Predictor for Market Chronology — E8 Intelligence Research

By projecting the 240 E8 root vectors onto the 132 Hz base field with phi‑coupled scaling, each distinct root length generates a unique harmonic timestamp that aligns with market phase transitions. The resulting phi‑scaled harmonic lattice predicts the exact convergence point of...

Development of national consensus-based recommendations for history taking, examination and clinical management of infants in chiropractic practice

Abstract Background Chiropractors in many countries provide care for infants, yet few structured, evidence-informed recommendations exist to guide history taking, examination, and clinical management in this population. In Denmark, variation in practice and limited public underst...

From Dietary Guidelines to Learning Policy Instruments

This independent project reviews monitoring and evaluation (M&E) provisions in selected African Food-Based Dietary Guidelines (FBDGs). It examines 11 guidelines listed on the FAO dietary-guidelines platform and assesses the extent to which they include FBDG-specific M&E arrangeme...

Evaluation of the structure and function of whey protein concentrate combined with folic acid and l ‐ascorbyl 6‐palmitate

Abstract BACKGROUND Whey protein concentrate 80 (WPC80) represents a highly promising carrier for bioactive compounds; however, the structural and functional consequences resulting from its noncovalent interactions with folic acid (FA) and l ‐ascorbic acid 6‐palmitate (LAP) remai...

SYSTEM EVOLUTION PROPOSALS (rlab #144) — E8 Intelligence Research

- Add a pipeline to automatically generate 2D/3D Coxeter plane projections of E8 using SageMath and overlay phi-harmonic spirals for angular alignment detection. - Integrate a module to cross-reference E8 symmetry numbers (240, 248, 30) with ancient metrology databases (Stoneheng...

Addressing Is Not Free: Factored Knowledge Storage and the Key-Discrimination Limit of Dense Models

Dense language models store factual knowledge superposed in their weights, paying an addressing cost that is real but invisible: no line item in any capacity account says what it costs to find a fact. We present a pre-registered measurement study of that cost from both sides of a...

BRPT Addendum: Ontology of Friendship under BAF/RMOF Interpretive Extension --- Not Canonical Amendment

This seminal BRPT addendum presents a formal, interpretive ontology for friendship and tribe under the Bifurcated Apex Framework (BAF) and Responsive Moral Oscillation Framework (RMOF). It rigorously models human relational coherence at scale, proposing that stable social bonds a...

Counterfactual Identification of Institutional Rupture: Evidence From Constitutional Transformation in Venezuela

How can institutional rupture be identified in settings where the treated unit is singular, interventions are composite, and institutional deterioration unfolds through mutually reinforcing constitutional, political, and legal transformations? We develop a counterfactual framewor...

The Puzzling Nature of Human Dignity: The Compatibility of MacIntyre’s Dignitas with Dignitas Infinita

This article argues that Alasdair MacIntyre’s final lecture on dignitas and the 2024 declaration Dignitas Infinita are better understood as asymmetrically supplementary rather than contradictory. MacIntyre finds modern conceptions of dignity, particularly universalist ones, conce...