Research works

Patient‐Reported Outcome Measures in Musculoskeletal Oncology: Current Concepts, Barriers, and the Future

Patient-reported outcome measures (PROMs) remain underutilized in musculoskeletal oncology, with only 4.9% of tumor-focused articles incorporating them. This review synthesizes current PROM instruments-including Toronto Extremity Salvage Score, PROMIS, and emerging tools such as...

Pediatric Venous Excess Ultrasound Score (P-VExUS): a novel approach to assess central venous pressure in the PICU

Abstract Accurate assessment of central venous pressure (CVP) in critically ill children is important for guiding fluid management but remains challenging, as invasive monitoring is not always feasible and noninvasive tools are limited. We aimed to develop and validate pediatric...

Accessing Syndiotactic Alternating Poly(lactic- co -glycolic acid) via Dual Regio- and Stereocontrol

Abstract Poly(lactic-co-glycolic acid) (PLGA) has attracted broad clinical attention for its exceptional biodegradability and biocompatibility. It is well established that the regio- and stereoregularity of PLGA has been shown to exert a significant influence on the material prop...

Microsurgical resection of brain metastases: rationale, appropriateness and local control

OBJECTIVE: To summarize data on indications for microsurgical resection of brain metastases, effect of resection technique on local control and leptomeningeal dissemination, as well as the role of stereotactic radiosurgery in improving local control. MATERIAL AND METHODS: A descr...

Centralized hashtags, embedded discourse: Two structural logics of youth climate activism on social media

Youth-led climate action increasingly unfolds on digital platforms, where hashtags structurally connect issues, actors, and publics. Using hashtag co-occurrence data (2022–2024) from prominent youth climate activists on X and Portuguese youth climate activists on Instagram, this...

EuroMillions Breakthrough Mining — 10431 Sources, 101630 Leads Extracted — E8 Intelligence Research

Mined 10431 lottery+quantum breakthroughs. Extracted 101630 leads across 13 categories. 97937 high-value leads found. Categories: {"CORRIDOR": 8887, "FORMULA": 8631, "GEOMETRIC": 1720, "FORWARD_ATTEMPT": 9341, "QUANTUM": 9593, "TIMING": 660, "CELESTIAL": 8695, "GEMATRIA": 9118, "...

Learning Popularity-Aware User Representations for Sequential Recommendation via Retrieval-Augmentation

Sequential recommendation methods are important in recommender systems, as they capture users’ dynamic interests from their historical behavior sequences. However, most existing methods have two limitations. First, they heavily rely on semantics from only a target user's interact...

Association between handedness and Alzheimer's disease: Results from a large MindCrowd observational study

BackgroundHandedness is tied to the lateralization of brain functions and significantly affects cognitive function and brain activity. Alzheimer's disease (AD) is a progressive brain disorder that leads to declines in memory, thinking skills, and to behavioral changes, which also...

Fetal adrenal microvascular index and adrenal volume in late‐onset fetal growth restriction: A prospective observational study

Abstract Objective This study evaluates the fetal adrenal gland microvascular index (MVI) and adrenal volume in late‐onset fetal growth restriction (FGR) using MV‐Flow and three‐dimensional Extended Imaging Virtual Organ Computer‐Aided Analysis and assesses their associations wit...

Demand-Sensitive Time Allocation in Digital Reading: Evidence from 25 Education Systems

Digital assessments record item-visit durations and revisiting. These traces can reveal responses to task difficulty, but achievement associations do not establish stable person-level measures. We linked digitalPIRLS 2021 process, response, and achievement data across 25 educatio...

Bilateral lower limb dysfunction due to acute hematoma in the lumbar ligamentum flavum

Rationale: There have been several reports of lumbar yellow ligament hematomas leading to cauda equina and/or nerve root compression. However, based on clinical history and histological findings, most of these cases involve chronic hematomas. Acute lumbar yellow ligament hematoma...

The i-Rheo Framework: A Unified Approach to Broadband Rheology and Microrheology of Soft Matter from Molecular Simulations to Biomechanics

Linear viscoelasticity provides a time-invariant mechanical fingerprint of materials and underpins predictive descriptions of their response to external deformation. The corresponding material functions reflect the hierarchy of inter- and intra-molecular interactions governing st...

One Subspace, Many Residuals: Columnwise Stopping and Rank Deflation for Block Projected Iterated Tikhonov Regularization

Discrete ill-posed problems with several right-hand sides and a common forward operator arise in multichannel imaging and in repeated or parameter-dependent experiments. A block Golub–Kahan reduction builds one solution subspace for all right-hand sides, and iterated Tikhonov reg...

Digitally Mediated Heritage Tourism for Sustainable Heritage Management: Evidence from the Liangzhu Heritage Site

How heritage tourism scenes evolve alongside digital mediation and how different forms of mediation are represented in visitor accounts remain insufficiently understood. This study examines the Liangzhu heritage site, centred on the Archaeological Ruins of Liangzhu City, using 71...

The Effect of Smile Cues on Food Calorie Perception: The Moderating Role of Dietary Restraint

ABSTRACT Consumers are becoming increasingly attentive to healthy eating and the caloric content of their food. However, when judging a food's calories, they often lack sufficient knowledge or objective information and therefore rely on marketplace cues to make subjective evaluat...

Age-stratified prevalence and associated risk factors of hypertension, diabetes and hypercholesterolemia in Nepal: Insights from the STEPS survey 2019

Background Non-communicable diseases (NCDs) are a major global public health challenge, particularly in low- and middle-income countries such as Nepal. Despite the growing burden of hypertension, diabetes, and hypercholesterolemia, limited evidence exists on age-stratified patter...

A novel perioperative pathway for hip fractures in the older adult: a pre-post quality improvement study using statistical process control

Despite advances in medical care, the incidence of medical complications, especially delirium, remains high in patients with hip fracture. Although individual components of hip fracture pathways have been studied, the components together have not. At a tertiary academic medical c...

Spelling error patterns in the co-occurrence of reading and spelling difficulties among Chinese children

Abstract Reading difficulties (RD) and spelling difficulties (SD) frequently co-occur in children and are associated with persistent spelling problems. However, little is known about spelling error patterns in Chinese among children with RD, SD, or their co-occurrence (RDSD). The...

Measuring Workload-Network Coupling in Local LLM Serving: Traffic Demand and Client Latency

AI workloads can change network demand, and network conditions can affect AI service latency. We measure one narrow part of this relationship: a locally served Qwen2.5-3B model under different application-path profiles, request concurrency, and output caps. On one Windows host wi...

Beyond Leaf Images: A Personalized Multimodal Temporal AI Framework for Pre-Symptomatic Plant Health Monitoring and Disease-Risk Early Warning

Artificial intelligence has advanced plant disease recognition, mainly through image-based deep learning. Its weakness is timing: a camera records a visible symptom, a model matches it to a known class, and a label is returned. This confirms disease but says little about the earl...