Afyonkarahisar Sağlık Bilimleri Üniversitesi

Synthesis, in silico study and cytotoxic evaluation of new benzimidazole derivatives as potential aromatase inhibitors

AIMS: ) was designed, synthesized, and evaluated as potential aromatase inhibitors with anticancer activity. MATERIALS AND METHODS: ADMET profiling were performed for the selected compounds. RESULTS: values (2.40-2.64 µM), surpassing cisplatin, while maintaining favorable selecti...

Narrative nursing: A primary ethical practice

Narrative medicine has emerged as an influential framework in contemporary healthcare, arguing that attending to patients’ stories improves the quality of clinical practice and ethical reasoning. Yet the conversation surrounding narrative practice has developed largely within med...

Long-Term Major Adverse Kidney and Cardiovascular Events in Predialysis Chronic Kidney Disease: A Real-World Cohort Study

Background and Objectives: Long-term renal and cardiovascular outcomes represent major clinical burdens in predialysis chronic kidney disease (CKD). This study aimed to evaluate the long-term incidence of and clinical factors associated with major adverse kidney events (MAKEs) an...

Respiratory health status and lung function among Syrian refugees compared with the local population: a cross-sectional field study

Respiratory health disparities among refugee populations constitute an important public health concern due to adverse living conditions and environmental exposures. However, comparative evidence based on objective lung function measurements between refugee and host populations fr...

Severity-Dependent Modulation of Visual Attention Under Fatigue During Bitewing Radiograph Inspection: A Perceptual Eye-Tracking Experiment

Purpose: To examine whether visual fatigue following a full clinical day differentially affects visual attention to approximal carious lesions of varying severity on bitewing radiographs using eye-tracking methodology.Methods: In this two-group experimental eye-tracking study, 60...

Newly qualified nurses’ experiences of ‘reality shock’: a phenomenological study

Background: The experience of starting a new job is a stressful period in which uncertainties, fear of lack of proficiency and concerns about an unfamiliar environment and people are experienced. Aim: This study was conducted to explore the reality shock experiences of newly qual...

Solvent-Dependent Phenolic Profiling and Bioactivities of Medicago marina L.: An Ultrasound-Assisted Extraction Approach

Despite previous phytochemical investigations of Medicago marina L., comparative information on the phenolic composition and multifunctional bioactivities of extracts obtained with different solvents remains limited. This study compared water and methanol extracts prepared by ult...

Organ-Specific Phenolic Profiles, Antioxidant Capacity, and Enzyme-Inhibitory Activities of the Turkish Endemic Origanum bilgeri

Background/Objectives: Origanum bilgeri P.H. Davis is a Turkish endemic Lamiaceae species whose non-volatile phenolic composition and organ-specific bioactivities remain unexplored. This study investigated the phenolic composition of flower, leaf, stem, and root extracts and eval...

Serum CEA, CA 19 − 9, and FDG PET/CT SUVmax in relation to histological subtype and overall survival in stage IV lung cancer

This retrospective study investigated the association of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19 − 9 (CA 19 − 9) levels with 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) findings, histological subtype, and overall...

Membrane Repositioning Techniques to Stabilize Graft Material in Lateral Sinus Augmentation: A Retrospective Cohort Radiographic Study

Purpose This retrospective study compares the effects of free-lay (FL) and tucked/adapted (TK) collagen membrane placement on vertical bone height (BH) in 2D radiographs after maxillary sinus augmentation (MSA) with the lateral window approach. Materials & Methods Patients who un...

Tumor budding and tumor-associated lymphocytic response as histopathological indicators of high-risk disease in head and neck cutaneous squamous cell carcinoma

Tumor budding (TB) and tumor-associated lymphocytic response (TALR) have emerged as promising histopathological indicators of tumor aggressiveness across epithelial malignancies. Recent studies have suggested that both tumor invasive activity and host immune response contribute s...

Chronotype, social jetlag, sleep quality, and somatic symptoms in medical students: A serial mediation analysis

Chronotype and social jetlag are important correlates of sleep and health, yet their joint relationship with somatic symptom burden remains insufficiently studied in medical students. This cross-sectional study examined the associations among chronotype, social jetlag, sleep qual...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...

Evaluation of patients’ anxiety and perceptions toward dental imaging modalities: a cross-sectional study

The aim of this study was to evaluate patients’ anxiety and perceptions regarding periapical radiography, panoramic radiography, cone-beam computed tomography (CBCT), and ultrasonography, and to examine the differences among these modalities from the patient’s perspective. This c...