Bilecik Şeyh Edebali Üniversitesi

Synthesis, in silico study and cytotoxic evaluation of new benzimidazole derivatives as potential aromatase inhibitors

AIMS: ) was designed, synthesized, and evaluated as potential aromatase inhibitors with anticancer activity. MATERIALS AND METHODS: ADMET profiling were performed for the selected compounds. RESULTS: values (2.40-2.64 µM), surpassing cisplatin, while maintaining favorable selecti...

Performance, Emission, Energy, and Exergy Assessment of Gasoline–1-Decanol, Gasoline–DIPE, and JP-8 Fuels Toward Sustainable Two-Stroke UAV Propulsion

This study experimentally investigates the performance, emission, energy, and exergy characteristics of six fuels in a two-cylinder, air-cooled, two-stroke unmanned aerial vehicle (UAV) engine, using neat gasoline (G100) as the reference fuel. The test matrix comprised G100, neat...

Effect of 12 weeks of zumba combined with halotherapy on body composition, respiratory, and cardiorespiratory parameters in sedentary older adults

This randomized controlled trial aimed to investigate the effects of a 12-week Zumba fitness program combined with halotherapy on body composition, respiratory function, and cardiorespiratory fitness in sedentary older adults, compared with Zumba training alone. Twenty sedentary...

Systematic Review of Geographical Information Systems and Remote Sensing in Assessing Climate‐Induced Water Resource Scarcity

ABSTRACT Climate change intensifies extreme precipitation, raises temperatures, and disrupts hydrological regimes, placing growing pressure on water resources. Remote sensing (RS) and geographic information systems (GIS) are widely used to monitor hydrological processes; however,...

Examining the Relationship Between Helicopter Parenting Attitudes, Mindfulness and School Adjustment

This study systematically investigated the complex relationships among adolescents’ perceptions of parental helicopter parenting, their dispositional mindfulness, and their overall adaptation to the school environment. The research framework was developed based on the relational...

The effect of anxiety toward AI-based health technologies on attitudes toward the use of telemedicine services: The mediating role of online privacy perception

Introduction This study aimed to examine the effect of individuals’ anxiety toward AI-based health technologies on their attitudes toward the use of telemedicine services and to determine the mediating role of online privacy perception in this relationship. Methods Designed withi...

Enhanced Acetone Sensing Performance of MgO/TiO 2 Bilayer Thin Films Prepared by Sol–Gel Spin Coating

This study comparatively investigates the performance of TiO 2 and MgO/TiO 2 bilayer thin films produced by sol–gel spin coating in acetone‐detecting metal oxide gas sensors. XRD and FESEM analyses showed that the MgO substrate improved the crystallization of TiO 2 films, increas...

Statistical Inference for Multi-sample of Geometric Processes with Lognormal Distribution

The geometric process is an important counting process model that serves as an alternative to non-homogeneous Poisson process models. It is widely used in reliability analysis, particularly in the modeling of repairable systems, due to its monotonic behaviour. Accurate statistica...

Suicidal ideation and associated factors in early and late onset late life depression

Early-onset depression (EOD) and late-onset depression (LOD), as subtypes of late-life depression (LLD), exhibit distinct clinical and biological characteristics. Patients with LLD are at an increased risk of developing suicidal behavior in the presence of suicidal ideation. This...

Mongolian Loanwords in Kazakh: A Semantic and Cultural Analysis

This study provides a detailed analysis of Mongolic loanwords in Kazakh in terms of their historical origins, phonological and morphological adaptation, and semantic change. The main source of the research is Kazak Tiliniŋ Kirme Sözder Sözdigi (The Dictionary of Borrowed Words in...

Design, Synthesis, and X-ray Characterization of Benzohydrazide Derivatives as Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: An Experimental and Computational Approach to Biological Activity

In this study, a series of new benzohydrazide derivatives (1a-i) were synthesized, and characterized as potential cholinesterase inhibitors for use in the treatment of Alzheimer’s disease (AD). The inhibitory activities of the synthesized compounds against acetylcholinesterase (A...

Measurement-Oriented Evaluation of Deep Learning Models for Automated Fetal Head Biometry in Prenatal Ultrasound

Background/Objectives: Accurate fetal head biometry, obtained via ultrasound imaging, is fundamental to prenatal assessment, as it enables fetal growth to be monitored and developmental abnormalities to be detected early. However, conventional manual measurements are time-consumi...

Early Neuroprotective Effects of Erucic Acid and Gentisic Acid on Hippocampal Glutamate Concentrations and Alzheimer-like Molecular Alterations in an Intracerebroventricular Streptozotocin Rat Model

Background: Alterations in glutamatergic homeostasis have been implicated in Alzheimer’s disease, but the relationship between total hippocampal tissue glutamate and Alzheimer-like molecular alterations remains unclear. This study evaluated the early neuroprotective potential of...

The role of general surgeons as manpower in colonoscopic screening programs

Objective: Colorectal cancer is a leading cause of cancer-related morbidity and mortality, and screening colonoscopies are crucial for early diagnosis and treatment. This study evaluates the quality of colonoscopies performed by general surgeons in a single center based on intern...

A spray‐dried dual microbial Wettable powder formulation: optimization and greenhouse efficacy against Western flower Thrips

Abstract BACKGROUND This study aimed to develop and evaluate a spray‐dried wettable powder (WP) formulation containing the entomopathogenic bacterium Serratia marcescens and the fungus Metarhizium flavoviride for the control of Frankliniella occidentalis . RESULTS The formulation...

Investigation of the Structural, Geometric, Spectroscopic, and Nonlinear Optical Properties of (E)-2-(2,4-dihydroxybenzylidene) thiosemicarbazone and (E)-2-[(1H-indol-3-yl)methylene] thiosemicarbazone complexes: A DFT Study

The optimized molecular geometries, vibrational frequencies, and both ¹H and ¹³C NMR spectra of (E)-2-(2,4-dihydroxybenzylidene)thiosemicarbazone (1) and (E)-2-[(1H-indol-3-yl)methylene]thiosemicarbazone (2) complexes were investigated using density functional theory (DFT) method...

Management of a Fully Deployed Coronary Stent Migrated to the Left Main Artery

Migration of a coronary stent is an uncommon but potentially dangerous event during percutaneous coronary intervention (PCI), and it is even rarer once the stent has been fully deployed. We describe a 39-year-old man presenting with non-ST elevation myocardial infarction (NSTEMI)...

Factors associated with mortality in Staphylococcus aureus bacteremia: the role of infectious diseases consultation

This study aimed to determine the predictors of 14th and 28th day mortality in Staphylococcus aureus bacteremia and to evaluate the risk factors of methicillin-resistant S. aureus (MRSA). Our study, designed as a single-center retrospective observational study, included adult pat...

Sürdürülebilirlik Odaklı Muhasebe Eğitimi: Karşılaşılan Zorluklar ve Dönüşüm Gereksinimi

Günümüzde toplumsal sorumluluk anlayışındaki değişimler, sürdürülebilirlik kavramını işletme yönetimi ve muhasebe uygulamaları açısından önemli hale getirmiştir. Geleneksel muhasebe eğitiminde finansal bilgi üretimi ve raporlaması yer alırken, sürdürülebilirlik kavramı muhasebeni...