Periodontitis GWAS Reveal Immune‐Biased Heritability Without Gingival Cell‐Type Resolution
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Abstract
Three methodologically distinct analyses partition periodontitis common-variant heritability across 27 gingival cell types. They agree on an immune-over-stromal direction but nominate three different top cell types, and a low-power analysis inverts the fibroblast signal; the current periodontitis GWAS therefore cannot resolve heritability to a single gingival cell type.
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Authors: Chengze Wang, Wenyue An, Mengna Lin, Ying Wang, Guoli Yang
Institutions: Zhejiang University, Zhejiang University Medical College Affiliated Stomatological Hospital