Zhejiang University Medical College Affiliated Stomatological Hospital

CD24 blockade reprograms macrophages and synergizes with CD47 blockade to overcome tumor immune evasion

Although immunotherapy has revolutionized cancer treatment, only a minority of head and neck squamous cell carcinoma (HNSCC) patients derive clinical benefit, underscoring the urgent need to uncover novel immune evasion mechanisms. CD24 serves as a pivotal innate immune checkpoin...

New periodontal phenotype classification in patients with different types of malocclusion and dental crowding

Abstract Background The periodontal phenotype plays a critical role in periodontal stability and orthodontic risk assessment. However, an integrated evaluation of soft‐ and hard‐tissue periodontal characteristics across various sagittal and vertical skeletal patterns and dental c...

Periodontitis GWAS Reveal Immune‐Biased Heritability Without Gingival Cell‐Type Resolution

Three methodologically distinct analyses partition periodontitis common-variant heritability across 27 gingival cell types. They agree on an immune-over-stromal direction but nominate three different top cell types, and a low-power analysis inverts the fibroblast signal; the curr...

The role of N6-methyladenosine (m6A) modification in the development and progression of head and neck squamous cell carcinoma (HNSCC): mechanistic insights and translational challenges

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent malignancy worldwide, encompassing tumors derived from the mucosal epithelia of the oral cavity, pharynx, larynx and other head and neck regions. Most patients are diagnosed at an advanced stage due t...

Silicon Nitride Nanofilm Functionalized Titanium Mesh for Boosting Osseointegration by Macrophage-Related Immunomodulation

Abstract Titanium mesh-supported guided bone regeneration (TM-GBR) has emerged as a clinically effective strategy for alveolar bone augmentation in complex defects, primarily through its ability to preserve osteogenic space and correct bone volume deficiencies. However, due to th...

A tendon-targeted zwitterionic nanogel for restraining osteoclast maturation to halt heterotopic bone formation

Tendinopathy is a prevalent degenerative musculoskeletal disorder that can progress to heterotopic ossification (HO), ultimately resulting in tissue stiffening and biomechanical deterioration. However, effective early-stage therapeutic strategies to prevent pathological ossificat...

Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis

Backgroud Dental fluorosis is a prevalent endemic condition, yet its impact on the oral microbiota structure and resistance in children remains understudied.Objective To assess the microbial composition, diversity, functional pathways and co-occurrence patterns among urinary fluo...

Application of an improved problem-based learning method in clinical endodontic training of standardized residents

Abstract Standardized residency training in stomatology is essential for developing competent dental professionals; however, improving clinical skills effectively remains a challenge in dental education. In this study, we implemented an improved problem-based learning (PBL) appro...

Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytes

Abstract Tendinopathy is a prevalent degenerative condition driven by complex metabolic dysregulation, yet its inherent metabolic heterogeneity remains poorly characterized, hindering targeted therapeutic development. To address this, we performed systematic multi-omics profiling...

Engineering Biomimetic Tumor Organoids Inspired by Janus Stiffness–Driven Cell Stemness

ABSTRACT Organoids become powerful platforms for modeling cancer biology but poorly preserve stemness due to inadequate biophysical cues. Cancer stem cells (CSCs), crucial for tumor growth, are rare and lose stemness under conventional in vitro conditions, limiting drug screening...