Zhejiang University Medical College Affiliated Stomatological Hospital

Engineering Biomimetic Tumor Organoids Inspired by Janus Stiffness–Driven Cell Stemness

ABSTRACT Organoids become powerful platforms for modeling cancer biology but poorly preserve stemness due to inadequate biophysical cues. Cancer stem cells (CSCs), crucial for tumor growth, are rare and lose stemness under conventional in vitro conditions, limiting drug screening...