Lifelong Genetic Inhibition of PCSK9 and Hepatic Safety
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Abstract
This genetic association study investigates whether the full spectrum of rare PCSK9 loss-of-function variants is associated with incident liver-related outcomes, given the development of therapies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9).
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Authors: Alessia Di Costanzo, Ilaria Pirona, Laura D’Erasmo, Silvia Buonaiuto, Vincenza Colonna, Allegra Via, Daniele Tramontano, Carlo Maiorca, Marcello Arca
Institutions: Sapienza University of Rome, Università Cattolica del Sacro Cuore, University of Tennessee Health Science Center, University of the Sacred Heart