Università Cattolica del Sacro Cuore

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Bilateral Internal Thoracic Artery Grafting in Coronary Surgery: A Three-Tier Decision Framework

The left internal mammary artery grafted to the left anterior descending artery (LAD) is the main determinant of survival in coronary artery bypass grafting, but the choice of the second graft remains controversial. The use of both mammary arteries offers a greater long-term surv...

Implementation of IRRAflow active irrigation in neurosurgical patients: A case series and literature overview

Background Active fluid management systems such as IRRAflow aim to overcome the limitations of passive external drains by enabling simultaneous automated irrigation and aspiration in a closed circuit. In acute and chronic subdural hematoma (a/cSDH), it enables active subdural irr...

Sustainable iodine contrast media for a healthy future (SUSTAINED): a global survey of practice

Abstract Objectives To investigate healthcare professionals’ knowledge, attitudes, and practices (KAPs) of the environmental impact and sustainability of iodinated contrast media (ICM). Materials and methods A cross-sectional web-based survey was distributed to members of profess...

Assisted Reproductive Technology and Risk of Congenital Heart Defects in the Offspring: A Systematic Review and Meta‐Analysis

Background To date, >10 million children have been conceived via assisted reproductive technology (ART) globally. However, there are some concerns about potential adverse outcomes associated with ART‐conceived pregnancies, including the risk of congenital heart defects (CHDs). Th...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Gendered Perceptions and the Use of Generative AI in Academia: An Experimental Vignette Study

ABSTRACT The adoption of Generative Artificial Intelligence (GenAI) is reshaping the very nature of work, yet its social meaning and evaluative implications—particularly for women—remain underexplored. Although existing research has mainly examined GenAI adoption, use, and algori...

Preliminary evidence of long‐term safety and effectiveness of anti‐ CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort o...

A Function-Led Tailored Speech-Language Intervention in Primary Progressive Aphasia: A Retrospective Observational Pre–Post Study From Routine Clinical Practice

PURPOSE: Primary progressive aphasia (PPA) is a neurodegenerative disease that affects language abilities. Since no curative or pharmacological treatments are currently available, speech-language therapy represents one of the few clinical intervention options. Furthermore, eviden...

Organizing healthcare delivery in the era of disease-modifying therapies for Alzheimer’s Disease: an Italian RAND/UCLA consensus

BACKGROUND: Alzheimer's disease (AD) poses a growing clinical and organizational challenge, requiring coordinated, multidisciplinary care models. In Italy, significant regional variability in resources and access to diagnostic services persists, while the implementation of commun...

Umbilical cord red blood cell transfusions in very premature neonates: A physiologically aligned transfusion strategy

The authors have disclosed no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Lung disease in crisponi/cold-induced sweating syndrome type 1: expanding the clinical phenotype spectrum

Crisponi/Cold-Induced Sweating Syndrome Type 1 (CS/CISS1) is an ultra-rare genetic disorder caused by biallelic variants in the cytokine receptor-like factor-1 (CRLF1) gene and is associated with several comorbidities. Comprehensive data on the respiratory phenotype of this condi...

Diagnosing Lennox–Gastaut syndrome in adulthood: A scoping review of diagnostic challenges and age‐related electroclinical evolution

OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy typically diagnosed in childhood. The 2022 International League Against Epilepsy (ILAE) criteria provide a diagnostic framework built on pediatric data, but their applicability in adulthood i...

Tibial Component Malalignment in Total Ankle Arthroplasty

Background: Total ankle replacement (TAR) has emerged as a valuable alternative to ankle arthrodesis for the treatment of end-stage ankle osteoarthritis, offering pain relief while preserving joint motion and improving quality of life. Despite advances in implant design and surgi...

Mitochondrial Remodeling and Impaired Bioenergetics Define Neuronal Vulnerability in Fragile X-Related Disorders

Fragile X syndrome (FXS) and related conditions associated with FMR1 gene alterations have increasingly been linked to mitochondrial dysfunction, although most available evidence derives from peripheral cell models. Whether these abnormalities also occur in disease-relevant neuro...

Mitigating Photo-Investment in Young Adult Women Through an Online Self-Compassion Intervention: A Controlled Study

Abstract Objectives Social media platforms centered on visual content, such as Instagram, often expose young women to idealized images, heightening body dissatisfaction and maladaptive behaviors related to photo-investment. Self-compassion has been identified as a protective fact...

Criminal infiltration in the legal economy: An empirical analysis of firms linked to organized crime

Organized crime increasingly exploits legitimate businesses to infiltrate the legal economy. While previous empirical research has mainly relied on confiscated firms and judicially identified cases, considerably less is known about firms identified through preventive administrati...

Radiographic accuracy of implant positioning in unicompartmental knee arthroplasty, does an imageless robotic system make a difference?

Abstract Background Robotic-assisted technologies and evolving implant designs have been introduced in unicompartmental knee arthroplasty (UKA) to improve the accuracy and reproducibility of component positioning. However, the relative contribution of robotic assistance compared...

School food environment and healthy eating in Italian schools: evidence from a nationwide teacher survey

School food environments (SFEs) are critical for shaping children’s nutrition and health. In Italy, national guidelines establish standards for school catering, yet decentralized governance generates substantial variability in meal quality, stakeholder engagement, and implementat...