Institution
University of Tennessee Health Science Center
Recent research
- Health & MedicineOpen access
Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...
- Engineering & Technology
Abstract Molecular dynamics simulations were employed to investigate the influence of alkali-metal ions (Li+, Na+, K+, and Cs+) and salt loading on the solvation structure, coordination environment, and transport properties of ternary electrolytes composed of a short-chain polyet...
- Health & MedicineOpen access
CliniSense AI for automated clinical skills assessment with real-time feedback
Medical education requires scalable, reliable assessment of clinical skills, yet faculty observation cannot meet trainee volume, manual OSCE evaluation yields inter-rater reliability of only κ = 0.35–0.58 with days-to-weeks feedback latency, and no existing system provides real-t...
- BiologyOpen access
Splicing genes as main targets of differential splicing
Abstract Splicing of transcripts via the spliceosome machinery is a complex process involving a multitude of proteins and short noncoding RNAs. In addition to full-length transcripts with all exons in the genomically encoded order, alternatively spliced transcripts can also be pr...
- Health & MedicineOpen access
The hematology workforce in the United States: past, present, and strategies for the future
From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...
- Health & MedicineOpen access
Obstructive shock from delayed blunt cardiac injury after chest trauma
Blunt cardiac injury (BCI) is a rare but serious presentation in emergency departments (EDs) nationwide. These injuries arise in trauma and may be accompanied by confounding injuries that complicate the clinical picture. Timely recognition is crucial, as BCI may lead to complicat...
- Health & MedicineOpen access
Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...
- Health & MedicineOpen access
Designing Reliable Care Through Clinical Pathways: A Human Factors Framework
Background/Objectives: Healthcare delivery systems are inherently complex, and efforts to improve quality and safety often fail to achieve sustained, system-wide impact because of misalignment between work system design, care processes, and clinical practice. This article present...
- Engineering & TechnologyOpen access
Abstract Rare earth elements (REEs), especially heavy rare earth elements such as dysprosium (Dy), have gained immense attention globally due to their widespread use in many state-of-the-art technologies. Consequently, demand for REEs is increasing rapidly in comparison to their...