University of Tennessee Health Science Center

Chromatin stability safeguards mitochondrial homeostasis and restrains TORC1 signaling

Chromatin is dynamically regulated in response to nutrient flux to promote the transcriptional changes needed for adaptation. The mechanistic target of rapamycin complex 1 (yeast TORC1) kinase integrates nutrient signaling with chromatin regulation, yet whether chromatin signals...

Choosing Value: Antivenom Selection in the Modern Trauma System

Background Venomous snakebites require timely antivenom administration to prevent progression of local and systemic toxicity. In the United States, two FDA-approved crotalid antivenoms, CroFab® and ANAVIP®, are available, both associated with substantial cost. Real-world data com...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Consumption of Unpasteurized (Raw) Milk and Milk Products by Pregnant People and Children: Policy Statement

Sales of unpasteurized (raw) milk and milk products remain legal in at least 27 US states. Unpasteurized milk and milk products from cows, goats, and sheep continue to be a source of infections attributable to several virulent pathogens, including Listeria monocytogenes, Campylob...

Engineering Metrics for Full-Scale Viability of PFAS Sorbent Regeneration

Abstract Evolving global regulations of per- and polyfluoroalkyl substances (PFASs) are driving rapid expansion of sorbent-based treatment in drinking water and industrial effluents. Granular activated carbon and anion-exchange resins remain among the best available technologies,...

Enhanced External Counterpulsation Versus Standard Medical Therapy for Chronic Refractory Angina: A Systematic Review and Meta-Analysis

Background: Chronic refractory angina is a disabling syndrome of persistent ischemic symptoms despite guideline-directed medical therapy and, in many patients, prior coronary revascularization. Enhanced external counterpulsation [EECP] is a noninvasive therapy that augments diast...

5-Fluorouracil-based chemotherapy disrupts autophagy flux and protein synthesis in cultured myotubes: a role for mTORC1 signaling

5-Fluorouracil-based chemotherapies, such as FOLFOX (5-fluorouracil, leucovorin, oxaliplatin), are used to treat colon cancer but also induce skeletal muscle toxicities. While FOLFOX can disrupt muscle autophagy signaling in vivo, the upstream mechanisms underlying this effect, a...

Bridging tumor growth dynamics and survival in preclinical oncology drug development – a Tumor Growth Inhibition and Time-to-Event (TGI-TTE) modeling framework

To develop a tumor growth inhibition and time-to-event (TGI-TTE) modeling framework linking drug exposure, tumor dynamics, and survival. Modeling used preclinical efficacy studies with MTMSA-Trp, a preclinical-stage anti-tumor agent for Ewing sarcoma. Tumor volume and survival da...

Lifelong Genetic Inhibition of PCSK9 and Hepatic Safety

This genetic association study investigates whether the full spectrum of rare PCSK9 loss-of-function variants is associated with incident liver-related outcomes, given the development of therapies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9).

Burden and Risk Factors for Severe Respiratory Syncytial Virus Infection Among Pediatric Hematopoietic Cell Transplant Recipients

BACKGROUND: Respiratory syncytial virus (RSV) causes substantial morbidity in pediatric hematopoietic cell transplant (HCT) recipients; however, risk factors for severe disease remain incompletely characterized. METHODS: We conducted a multicenter retrospective cohort study acros...

Rational Quantification of Deep Sodium Reversibility with a Utilization-Corrected N/P Descriptor toward Low-N/P-Ratio Solid-State Na–S Batteries

Abstract Solid-state Na–S batteries offer high energy density, yet their practicality deteriorates at low N/P ratios because limited Na inventory cannot compensate for irreversible loss. Under lean-Na conditions, the key issue is whether the restricted Na reservoir remains revers...

Role of Acid Structure in Structure–Property Relationships of Reprocessable Epoxidized Soybean Oil Thermosetting Networks

Thermosetting polymers offer excellent thermal stability, chemical resistance, and mechanical integrity, but their permanent covalent crosslinks limit recyclability and reprocessability. In this work, ESO-based vitrimer-like polyester networks were synthesized from epoxidized soy...

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems

Importance Although fluoride exposure at high levels during the perinatal period has been associated with socioemotional problems among children, there is limited evidence regarding potential associations at lower levels of fluoride exposure, particularly in the US. Objective To...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

Communication as Mediator: Interprofessional Deprescribing and the RCC (Roles–Collaboration–Communication) Framework

Background: Polypharmacy remains a significant challenge, often leading to adverse drug events and increased healthcare costs. One effective strategy to mitigate these risks is deprescribing, the systematic and intentional discontinuation or reduction of medications. Despite grow...

Modulatory effects of S1QEL on OxLDL-induced metabolic alterations and inflammatory responses in human monocytes

Background Oxidized low-density lipoprotein (OxLDL) plays a key role in initiating monocyte activation, glycolytic reprogramming, and pro-inflammatory cytokine production—processes that contribute to aging and progression of age-related diseases such as atherosclerosis and steato...

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...

Effect of AlkaliMetal Ions and Salt Composition onStructural and Dynamical Properties of Ternary Electrolytes

Abstract Molecular dynamics simulations were employed to investigate the influence of alkali-metal ions (Li+, Na+, K+, and Cs+) and salt loading on the solvation structure, coordination environment, and transport properties of ternary electrolytes composed of a short-chain polyet...

CliniSense AI for automated clinical skills assessment with real-time feedback

Medical education requires scalable, reliable assessment of clinical skills, yet faculty observation cannot meet trainee volume, manual OSCE evaluation yields inter-rater reliability of only κ = 0.35–0.58 with days-to-weeks feedback latency, and no existing system provides real-t...