Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality
Abstract
Abstract Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread exposure. Our re-analysis of cervicovaginal metabolomes revealed elevated paraben metabolites in endometrial and cervical cancer patients compared with controls. Overall, longitudinal studies considering intrinsic and environmental factors are needed in assessing paraben-related cancer risk.
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Authors: Zehra Esra Ilhan, Andrea Marchetto, Georgia Lorentzen, Paweł Łaniewski, Leslie V. Farland, Melissa M. Herbst‐Kralovetz
Institutions: Imperial College London, University of Arizona, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université Paris-Saclay, AgroParisTech, Microbiologie de l’alimentation au service de la santé, University of Phoenix