Microbiologie de l’alimentation au service de la santé

Structure‐Based Annotation by AlphaFold3 Predictions of the Francisella halioticida T6SS Encoded in the Francisella Pathogenicity Island

ABSTRACT Francisella halioticida has emerged as a significant pathogen of cultured molluscs, causing substantial economic losses due to mass mortalities. The Francisella Pathogenicity Island encodes a Type VI secretion system essential for virulence and intracellular persistence....

Next-generation probiotics: beyond lactic acid bacteria to untapped taxa and engineered strains for better health

In this perspective, we discuss the evolving landscape of next-generation probiotics (NGPs), challenging the ambiguity of the term and proposing a framework for unifying the concepts associated with the field. We highlight the potential of novel candidates, including lactic acid...

Five-country analysis of geographic and dietary drivers of gut microbiome composition and genomic variation

Abstract Human diet and lifestyle vary widely across cultures, shaping global diversity in gut microbiome composition and function. However, comparable cross-population studies have been limited by methodological heterogeneity. The Human Diets and Microbiome Initiative (THDMI) in...

Dietary prevention of undernutrition reduces intestinal inflammation associated with an anti-inflammatory profile of gut microbiota in a preclinical model

Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality of life in IBD patients. The aim of this study was to...

Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality

Abstract Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread e...

Coupling of stable isotope probing and metagenomics reveals the diversity of viruses infecting formatotrophs during anaerobic digestion process

Abstract Background Viruses play a major role in regulating microbial community composition and activity, yet their diversity and host associations in anaerobic digestion (AD)—a complex biotechnological process converting organic waste into biogas—remain poorly characterized. Lin...