Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.
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Abstract
). Their interdependent dysregulation accelerated HCM. This study establishes the simple telegraph model as a scalable framework linking transcriptional burst dynamics to cell fate and pathology.
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Authors: Liang Chen, Yuwen Wu, Chengkai Yang, Sijia Fang, Yu Liao, Yueheng Wu, Hongkun Zhang, Guozhi Jiang, Jianshe Yu, Feng Jiao
Institutions: Sun Yat-sen University, Southern Medical University, Shenzhen Bay Laboratory, Guangzhou University