Guozhi Jiang

Sex-Specific Plasma Proteomic Alterations Underpin Distinct COVID-19 Progression and Post-COVID-19 Condition

Abstract Sex differences in COVID-19 and its sequelae remain poorly understood, which hinders targeted therapies. We performed plasma proteomic analyses of 69 hospitalized patients with COVID-19 and 30 healthy controls from a prospective Chinese cohort. The UK Biobank and Mount S...

Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.

). Their interdependent dysregulation accelerated HCM. This study establishes the simple telegraph model as a scalable framework linking transcriptional burst dynamics to cell fate and pathology.