Shenzhen Bay Laboratory

An automated operon refactoring workflow for heterologous expression of non-ribosomal peptide biosynthetic gene clusters

Microbial genomes encode numerous biosynthetic gene clusters, yet most remain experimentally uncharacterized, particularly large non-ribosomal peptide synthetase (NRPS) clusters that resist conventional cloning. Existing refactoring approaches are labor-intensive, depend on de no...

Product evolution model (PEM): a functional semantic knowledge-driven framework for product technology landscape construction

Purpose The construction of a product technology landscape remains heavily reliant on patent-based methods despite its recognized value in supporting the systematic product planning and technology opportunity identification. These patented approaches, however, are typically const...

A Multi‐Objective Optimization Framework for Locating Metro Stations by Integrating Travel Demand, Accessibility, and Land Use Intensity

ABSTRACT Transit‐Oriented Development (TOD) strategies help to achieve sustainable transportation and vibrant communities. The selection of suitable locations for metro stations plays a fundamental role in implementing TOD planning. However, current research predominantly focuses...

Fragmentomic features of cell-free DNA in human spent blastocyst medium and their potential for non-invasive embryo ploidy assessment

To characterize the fragmentomic features of cell-free DNA (cfDNA) in spent blastocyst medium (SBM) and their association with embryonic chromosomal status. One hundred fifty SBM samples were obtained from 43 preimplantation genetic testing for aneuploidy (PGT-A) cycles in 39 pat...

2D MoS 2 /Au Interfaces For Enhanced Opto–Electronic Response With Sub‐Bandgap Photons

ABSTRACT Monolayer is a direct bandgap semiconductor with potential applications in optoelectronics and photonics. also has a large optical nonlinearity. However, the atomic thickness of the monolayer limits the strength of the measured functional signals, such as the photocurren...

Epigenetic training licenses naïve CD8 + T cell metabolic fitness and function

Naïve T cells maintain quiescence yet must respond rapidly to antigens, but how they prime this capacity is unclear. We identify histone variant H2A.Z as a key regulator of an epigenetic training program that licenses quiescent naïve CD8 + T cells for future activation. H2A.Z def...

Undernutrition enhances host attractiveness to mosquitoes and transmission of mosquito-borne diseases

Undernutrition is prevalent in regions affected by mosquito-borne diseases. Understanding how insufficient nutrition affects the transmission of mosquito-borne pathogens is critical for combating these diseases. In this study, we found that undernourished mice were more attractiv...

Fused Triphenylamine‐Terminated Self‐Assembled Hole‐Transporting Monolayers for Perovskite Solar Cells

ABSTRACT Conventional self‐assembled hole‐transporting monolayers (SAMs) in perovskite solar cells (PSCs) suffer molecular aggregation, uneven coverage on rough FTO substrates, and insufficient interfacial defect passivation. The design and application of novel SAMs have become a...

Cross-region zero-shot bike-sharing demand prediction with transitive transfer learning using multi-modal public transit data

Predicting bike-sharing demand in regions without historical data is essential for early-stage fleet allocation and rebalancing. However, conventional supervised forecasting models rely on region-specific historical observations and often generalize poorly across heterogeneous ur...

Catalytic Insertion of Pd–Vinylidenes Into B─H Bonds

ABSTRACT An unprecedented palladium (Pd)‑catalyzed insertion of unsaturated carbenes into B─H bonds is described. Using alkynyl hypervalent iodine reagents as carbene precursors and amine–borane adducts as boron sources, this method delivers a broad range of E ‑configured alkenyl...

Gap-tuned exceptional skin effect in non-Hermitian flat bands

Flat-band states in Hermitian systems exhibit compact localization in the bulk due to geometric or symmetry constraints, while non-Hermitian skin effects drive state accumulation at boundaries via asymmetric lattice hoppings. Despite extensive efforts devoted to studying these tw...

Identifying ion and carrier behavior in perovskite solar cells through impedance spectra

Abstract Due to the interference of ion dynamics in perovskite materials, specifically the mixed ionic-electronic conduction property, the impedance response of perovskite solar cells exhibits numerous anomalous features. Herein, we conduct numerical simulations using the drift-d...

Discovery of CDK8/19 inhibitors as lead compounds for IL-6–dependent lymphoma enabled by the formal synthesis of cortistatin A

A formal synthesis of cortistatin A, a marine-derived steroidal alkaloid with potent anti-angiogenic and antileukemic activities, was achieved via a unique synthetic strategy that leveraged a late-stage SmI 2 -mediated oxa-bridge translocation. The de novo–synthesized simplified...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Functional characterization of a pore‐forming effector TseMt from the H4 type VI secretion system of Pseudomonas aeruginosa

Abstract Pseudomonas aeruginosa is a major nosocomial pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, additional T6SS clusters have been identified in clinical isolates through c...

Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data.

). Their interdependent dysregulation accelerated HCM. This study establishes the simple telegraph model as a scalable framework linking transcriptional burst dynamics to cell fate and pathology.

Photon‐Recycling Dielectric Laser Accelerator

ABSTRACT We propose a photon‐recycling dielectric laser accelerator (DLA) system based on silicon‐on‐insulator platform. Our DLA system employs transverse‐magnetic optical mode as the primary energy source, modulated and injected into the electron‐light interaction region for lon...

China’s Policy Responses to High Oil Prices: Balancing Macroeconomic Stability and Low-Carbon Transition

International oil price volatility poses severe risks to macroeconomic stability and energy security, presenting complex policy challenges for China as it simultaneously pursues economic growth and a low-carbon transition. To bridge the gap between general equilibrium reallocatio...

Potential structure induced effects of the hairpin motif in RNA to form the phase separated droplet like associate in different solution condition

Reversible associations of RNAs among themselves, or with RNA binding proteins through the process of phase separation, are found to be important in many different cellular contexts, including cellular responses to stress, gene regulation, development, and disease. Short RNA repe...

Real‐Space Mapping of Emergent Correlated Electronic States With Scanning SQUID Microscopy

ABSTRACT Scanning superconducting quantum interference device (SQUID) microscopy provides ultrahigh magnetic field sensitivity and has emerged as a powerful real‐space probe for correlated quantum phenomena in condensed matter. By reducing the superconducting loop to submicron re...