Lytic activity of F8-like phage φSPM-1 against One Health lineages of carbapenem-resistant Pseudomonas aeruginosa
Abstract
Abstract The increasing resistance of Pseudomonas aeruginosa to carbapenem antibiotics is shifting the landscape of high-risk clones from a strictly hospital-acquired threat to a global pathogen with One Health relevance. Given the limited therapeutic options available, developing new treatments is essential. We previously reported the complete genome sequence of φSPM-1 phage from the family Myoviridae . In this study, we show that φSPM-1 displays lytic activity against hospital and environmental metallo-β-lactamase (MβL)-producing P. aeruginosa and confers a protective effect against lethal infection caused by the high-risk clone ST277 in a Galleria mellonella prophylactic model.
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Authors: Patrícia Neves, Karine Dantas, Gregory Melocco, Helena Turano, Fernanda Esposito, Ana Cristina Gales, Carlos Emílio Levy, Elsa M. Mamizuka, Nilton Lincopán
Institutions: Universidade de São Paulo, Universidade Estadual de Campinas (UNICAMP), Universidade Federal de São Paulo