Universidade Federal de São Paulo

Cation-aromatic nitrogen interaction as a design principle for sodium deep eutectic electrolytes

We report a combined experimental and ab initio molecular dynamics investigation into the role of nitrogen hybridization (sp2 vs sp3) and ring aromaticity in the sodium-based deep eutectic electrolyte formation and their potential use in sodium-ion battery electrolytes. Mixtures...

Albumin Precoating of Nanoparticles: A Reliable StealthStrategy?

Abstract Albumin precoating has emerged as a strategy to impart nanoparticles (NPs) with stealth-like properties and as an alternative to NP surface PEGylation. Yet how such coatings influence protein corona formation and hemocompatibility in human blood remains poorly understood...

Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain

Zika virus (ZIKV) infection during early development is associated with severe neurodevelopmental impairment, including congenital microcephaly, yet the molecular mechanisms linking viral exposure to neuronal dysfunction remain incompletely understood. Ndel1 (nudE neurodevelopmen...

cAmbly, a peptide derived from the star tick Amblyomma sculptum salivary gland transcriptome, attenuates inflammatory pain by activating endogenous opioid pathways

Pain affects more than 1.5 billion people worldwide and remains a leading cause of disability, but currently available analgesics often have limited efficacy and significant adverse effects. In this context, bioactive molecules derived from animal venoms and secretions have emerg...

Development and usability evaluation of a software prototype for quality management in Human Milk Banks: a methodological study

Human Milk Banks (HMB) are specialized services that promote, protect, and support breastfeeding, as well as process, control, and distribute donated human milk, especially for premature or hospitalized infants. Brazil has the largest and most consolidated HMB network worldwide,...

Persistent Redox Imbalance in Post-COVID-19 Syndrome: Lipid Peroxidation, Antioxidant Enzyme Depletion, and Reduced Nitric Oxide Availability in an Amazonian Population

Post-COVID-19 syndrome (PCS) can persist even after mild acute illness, and oxidative stress has been proposed as a central mechanism for this persistence, although it remains poorly studied in the Amazon. This study characterized redox imbalance in patients with PCS through a co...

Highly Stretchable Eu 3+ ‐ Doped PEBAX Elastomers With Complementary Optical Readouts of Strain and Temperature

ABSTRACT Soft photonic materials capable of maintaining optical functionality under large mechanical deformation are highly desirable for wearable photonics, flexible sensors, optical and mechanically adaptive photonic systems. Here, we report highly stretchable luminescent elast...

Routine MRI for opportunistic osteoporosis screening: diagnostic accuracy of vertebral bone quality and a novel femoral bone quality score compared with DXA

OBJECTIVES: To evaluate vertebral bone quality (VBQ) and femoral bone quality (FBQ) scores as potential imaging markers of bone mineral density (BMD) for opportunistic osteoporosis screening in at‑risk patients and to assess their correlation with DXA T-scores. METHODS: This retr...

Acidic StressInduces Proteomic Reprogramming andVirulence-Associated Adaptation in Paracoccidioides brasiliensis

Abstract Paracoccidioidomycosis (PCM) is a neglected systemic mycosis whose etiologic agents must adapt to acidic host niches such as phagolysosomes. Here, we used quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics to define the response of Pa...

Is self-reported daylight exposure reliable? A validation study with actigraphy in urban environments

Daylight exposure is an environmental determinant of human health, yet measuring real-world exposure at scale remains a major challenge. Large population studies frequently rely on self-reported time spent outdoors as a proxy for daylight exposure, although the validity of this m...

Lytic activity of F8-like phage φSPM-1 against One Health lineages of carbapenem-resistant Pseudomonas aeruginosa

Abstract The increasing resistance of Pseudomonas aeruginosa to carbapenem antibiotics is shifting the landscape of high-risk clones from a strictly hospital-acquired threat to a global pathogen with One Health relevance. Given the limited therapeutic options available, developin...

Segurança dos alimentos em desastres climáticos e a abordagem Uma Só Saúde

Este projeto reúne estudos e materiais sobre os impactos de desastres climáticos na segurança dos alimentos, considerando as relações entre ambiente, infraestrutura, sistemas produtivos, saúde humana, animal e vegetal. O enfoque parte da abordagem Uma Só Saúde, que reconhece a in...

Genotypic features of antimicrobial resistance, virulence determinants, and clonal lineages of Enterococcus spp. reported in Brazil: a scoping review with marked regional asymmetry

Abstract Purpose Vancomycin-resistant Enterococcus faecium is listed in the 2024 WHO Bacterial Priority Pathogens List as a high-priority agent of hospital-acquired infections. Its persistence is supported by marked genomic plasticity across human, animal, food, and environmental...

The bulging pancreas: unmasking causes beyond autoimmunity—an imaging-based approach to diffuse pancreatic enlargement

Abstract Diffuse pancreatic enlargement is frequently attributed to autoimmune pancreatitis (AIP), but several benign, genetic, inflammatory, including acute interstitial edematous pancreatitis, and malignant entities can produce a similar imaging appearance. This review provides...