Ana Cristina Gales

Phage heteroresistance in clinical Klebsiella pneumoniae isolates: impact of differentiated capsule expression on phage efficacy

Abstract Heteroresistance, commonly described in the context of antibiotics, refers to the presence of resistant subpopulations within a bacterial strain, and is recognized as a likely contributor to treatment failure. Whether population heterogeneity affects phage activity remai...

Lytic activity of F8-like phage φSPM-1 against One Health lineages of carbapenem-resistant Pseudomonas aeruginosa

Abstract The increasing resistance of Pseudomonas aeruginosa to carbapenem antibiotics is shifting the landscape of high-risk clones from a strictly hospital-acquired threat to a global pathogen with One Health relevance. Given the limited therapeutic options available, developin...

Genotypic features of antimicrobial resistance, virulence determinants, and clonal lineages of Enterococcus spp. reported in Brazil: a scoping review with marked regional asymmetry

Abstract Purpose Vancomycin-resistant Enterococcus faecium is listed in the 2024 WHO Bacterial Priority Pathogens List as a high-priority agent of hospital-acquired infections. Its persistence is supported by marked genomic plasticity across human, animal, food, and environmental...