Neuroscience · Cellular and Molecular Neuroscience

Neurotransmitter Receptor Influence on Behavior

Abstract editorial illustration accompanying the article: Dexmedetomidine eased methamphetamine-driven overheating and activity in male rats

Dexmedetomidine eased methamphetamine-driven overheating and activity in male rats

In male rats, dexmedetomidine reduced the overheating and excessive movement caused by methamphetamine. It also suppressed methamphetamine-related increases in dopamine and noradrenaline in the anterior hypothalamus, but did not significantly change serotonin levels.

1 week ago·51 views

Abstract editorial illustration accompanying the article: Enriched surroundings partially restored key inhibitory brain cells after early NMDA blockade

Biology

Enriched surroundings partially restored key inhibitory brain cells after early NMDA blockade

Early blockage of NMDA receptors in male rats led to long-lasting changes in inhibitory interneurons in the visual cortex, including fewer parvalbumin-positive cells. When the rats later lived in enriched environments, parvalbumin cell counts rose and several plasticity-related protein markers increased, while NMDA receptor NR1 levels did not recover.

1 month ago·54 views