Biochemistry, Genetics and Molecular Biology · Molecular Biology

Diffusion and Search Dynamics

DNA damage changes nearby DNA’s shape, which may help repair proteins find it

Different forms of DNA damage changed the shape and movement of surrounding DNA in laboratory tests. The findings suggest that these physical changes could provide an early signal that helps repair proteins locate damage, before they directly engage with it.

3 days ago·19 views

Biology

Cohesin keeps active DNA regions from blending together in human cells

Researchers found that active parts of the human genome form condensed domains whose movement is constrained by cohesin, a protein complex that helps organize DNA. When cohesin was lost, nucleosomes became more mobile within the domains, allowing nearby regions to mix and weakening transcriptional insulation.

1 month ago·69 views