Zhongshan Hospital

Two-wave modified cardiometabolic index change patterns and incident edentulism in Chinese adults: a longitudinal study from CHARLS

Abstract Objectives Complete tooth loss is a late-stage oral health endpoint that may reflect cumulative oral, systemic, behavioral, and social risk processes. We examined whether two-wave patterns of the modified cardiometabolic index (MCMI) from 2011 to 2015 were associated wit...

The early dFLC level after autologous stem cell transplantation can predict the long-term prognosis of in patients with light chain amyloidosis

Abstract Recent studies show that the post-treatment difference between involved and uninvolved light chains (dFLC) predicts long-term prognosis in light chain (AL) amyloidosis. However, this issue remains underexplored in patients treated with autologous stem cell transplantatio...

Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis

Background: Humoral immunity targeting hepatitis B virus (HBV) surface antigen (HBsAg) is critical for viral clearance. However, the phenotypic, repertoire, and metabolic features of HBsAg-specific B cells in chronic hepatitis B (CHB) remain incompletely defined. Methods: HBsAg-s...

2-methylbutanal remodels arachidonic acid metabolism and antitumor immunity through ENO1 in colorectal cancer

Active aldehydes are increasingly recognized as bioactive metabolites, but their roles in tumor immune regulation remain poorly defined. In colorectal cancer (CRC), prostaglandin metabolism contributes to immune suppression, whereas its upstream metabolic regulators are incomplet...

MXene-Based Conductive Microneedle Patch Promotes Diabetic Wound Healing by Regulating Oxidative Stress and Immune Microenvironment

Abstract Excessive reactive oxygen species (ROS) generation and the release of inflammatory mediators create a pathological microenvironment in diabetic wounds, severely impairing the healing process. Coupling endogenous electric fields has shown great therapeutic potential for i...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Benchmarking RNA-seq with the Quartet and MAQC reference materials to establish best practices for accurate alternative splicing analysis

Previous limited characterization of short-read RNA-seq (srRNA-seq) accuracy in alternative splicing (AS) analysis due to methodological diversity and lack of reference standards, has left unclear how to achieve optimal performance—an issue increasingly critical with the rise of...

Associations Between the Inflammation Burden Index and Cardiovascular–Kidney–Metabolic Syndrome: A Cross-Sectional Study Based upon the NHANES Database

Background: Cardiovascular–kidney–metabolic (CKM) syndrome is a systemic disorder manifested as the interconnected dysregulation of cardiovascular disease, chronic kidney disease, and metabolic abnormalities. Systemic inflammation was identified as an important contributor to CKM...

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Abstract Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, i...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...

From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease

Panvascular diseases (PVDs) stand as the leading cause of global mortality, necessitating a paradigm shift from local anatomical repair to the systemic restoration of vascular homeostasis. While intravascular optical imaging has revolutionized diagnosis, it remains a passive obse...

Adenosine 2A receptor drives microglial efferocytosis to accelerate white matter repair and functional recovery after stroke

Although reperfusion therapy effectively restores blood flow to occluded brain arteries after ischemic stroke, many patients develop persistent white matter injury, a major contributor to long-term neurological disability. Currently, there are few approved clinical therapies that...

Tazemetostat combined PD-1 inhibitor achieving prolonged survival in primary proximal epithelioid sarcoma: a case report and review of the literature

Abstract Background Epithelioid sarcoma (ES) is a rare mesenchymal tumor categorized into proximal (axial) and classical (distal) types. In general, proximal ES come alone with limited treatment options and poor prognosis. Herein, we present the case of a proximal ES treated with...

Impact of oral nutritional supplements on chemotherapy tolerance and overall survival in postoperative colorectal cancer patients undergoing chemotherapy.

BACKGROUND AND OBJECTIVES: The primary objective of this study was to evaluate the efficacy of oral nutritional supplements (ONS) on chemotherapy tolerance and long-term survival outcomes in postoperative colorectal cancer patients undergoing chemotherapy. METHODS AND STUDY DESIG...

Burdens of pancreatic cancer from 1990 to 2021 and projection to 2050 in China: findings from the 2021 global burden of disease study

<title>Abstract</title> Background Pancreatic cancer in China exhibits high incidence and mortality rates, imposing a significant disease burden. It is essential to clarify the trends in pancreatic cancer from 1990 to 2021 and predict future trends up to 2050, which can provide v...