Zhongshan Hospital

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction

Significance: Copper is an essential redox-active micronutrient, but failure of copper compartmentalization can convert it from a catalytic cofactor into a source of oxidative, proteotoxic, and mitochondrial stress. Neutrophils are a plausible target of this transition because th...

Interleukin-15-armed trivalent mRNA vaccine elicits robust and durable protection against lethal mpox and vaccinia virus challenges in mice

The global re-emergence of mpox virus (MPXV) poses a critical threat, particularly to vulnerable immunocompromised populations, thus highlighting an urgent need for effective and safe interventions. In this study, we developed and compared three mRNA-LNP candidates: a trivalent c...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

The effect of HIF-PHIs on anemia in non-dialysis-dependent CKD patients: a systematic review and network meta-analysis

This study compared the effects of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) and erythropoiesis-stimulating agents (ESAs) on anemia in non-dialysis-dependent chronic kidney disease (ND-CKD), with emphasis on follow-up duration and iron-metabolism markers....

Periodic Mesoporous Metal Oxides With Consistent Structure and Complementary Sensing Selectivity for Reliable Artificial Olfactory

The integration of functional materials and intelligent algorithms has endowed artificial olfactory systems with promising potential across various fields. Nevertheless, their accuracy and reliability in practical gas recognition remain constrained, primarily due to the unrefined...

A case of hypertensive retinopathy developing during pembrolizumab treatment for intrahepatic cholangiocarcinoma

To report the first documented case of severe vision loss due to secondary hypertensive retinopathy associated with pembrolizumab therapy, thereby expanding the known spectrum of ocular toxicities from immune checkpoint inhibitors (ICIs). A 54-year-old woman with intrahepatic cho...

Metabolic and vascular stress drive progression of erectile dysfunction in a rat model

Erectile dysfunction (ED) is a common male sexual disorder, with the vasculogenic subtype primarily driven by endothelial injury and metabolic dysfunction. Current research often lacks a systematic, time-course analysis of its progressive pathology. We performed a 16-week time-co...

Integrated Multi‐Omics Analysis Identifies HVCN1 as a Potential Mediator in Neuroendocrine–Tumor Interactions in Colorectal Cancer

ABSTRACT Objective To investigate associations among sleep‐related features, neuroendocrine alterations, and colorectal cancer (CRC)‐related molecular programs, and to identify candidate genes involved in hypothalamus–tumor interactions. Methods NHANES data were analyzed to asses...

Research on Optimization and Performance Analysis of Centrifugal Blood Pump Blade Parameters Based on Numerical Simulation

Abstract Objective: Taking the centrifugal blood pump as the research object, this study investigates the effects of blade type and blade wrap angle on pump performance, aiming to determine the optimal blade configuration and the appropriate range of the correlation coefficient φ...

Multisystem involvement in extramedullary plasmacytoma: diagnostic challenges and clinical implications—a case report

Extramedullary plasmacytoma (EMP) represents 3–5% of plasma cell tumors and is commonly found in the head and neck region, upper respiratory tract, and gastrointestinal tract. Cardiac and primary lung parenchymal involvement are extremely rare. This case report describes an unusu...

Dispersion-Controlled Carbon Nanotube Networks Enable Tunable Structure–Performance–Stability Relationships in RuO x · n H2O Pseudocapacitive Electrodes

Abstract The electrochemical performance of pseudocapacitive electrodes is closely related to their nanoscale structure and conductive network formation. In this study, hydrous RuOx·nH2O electrodes with controlled carbon nanotube (CNT) dispersion were fabricated via a cathodic de...

The dawn of RAS-targeted therapy: a landmark breakthrough of daraxonrasib in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. More than 80% of patients are diagnosed at an advanced stage, and the 5‑year survival rate remains approximately 13% [ 1 , 2 ]. For patients with metastatic PDAC (mPDAC), first-line chemotherapy...

Lactate drives maladaptive metabolic reprogramming via MRS2 in ischemia/reperfusion-induced acute kidney injury

Ischemia/reperfusion (I/R) triggers profound bioenergetic collapse in renal proximal tubular epithelial cells (PTECs), inducing acute kidney injury (AKI) and forcing a sustained shift from mitochondrial oxidative metabolism to glycolysis. Lactate accumulation is a hallmark of thi...

Discordant Interleukin-27 (IL-27) Subunit Transcription in Human Sepsis Exposes a Molecular-Attribution Gap

Background/Objectives: Interleukin-27 (IL-27) is an obligate EBI3–p28 heterodimer, yet sepsis studies commonly measure and target the axis as a single entity. We tested whether both subunit transcripts are coordinately induced in septic monocytes and whether the axis has function...

Unraveling the Scale Effect on Fracture Plugging: A Quantitative Study from Lab-Scale Slots to Field-Scale Fractures via Hydrodynamic Analysis

Abstract Conventional core-scale laboratory fracture-plugging tests may overestimate the ability of granular lost circulation materials (LCMs) to form a complete plugging zone under field-scale conditions. This discrepancy arises because the effects of increasing fracture length...

Cross-Omics Identification and Validation of PCSK9 as a Candidate Molecule Associated with Aortic Dissection and Negative Remodeling After TEVAR

Background: Negative aortic remodeling after thoracic endovascular aortic repair (TEVAR) remains a major challenge in patients with type B aortic dissection (TBAD). This exploratory study aimed to integrate human aortic tissue transcriptomic data with serum proteomic profiles fro...

Predicting left-ventricular recovery and characterizing Cardiorenal risk after Transcatheter aortic valve replacement: A routine-data phenotyping and prediction-model study

Background Ejection fraction (LVEF) underpins risk stratification before transcatheter aortic valve replacement (TAVR), yet it does not indicate whether an impaired ventricle will recover once the stenosis is relieved, or what drives death in high-risk patients. We asked whether...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Early inflammatory response is associated with antibiotic treatment outcomes in acute phlegmonous appendicitis: a retrospective cohort study

Acute phlegmonous appendicitis is considered an intermediate inflammatory subtype between uncomplicated and complicated appendicitis. Although nonoperative management is increasingly accepted for uncomplicated appendicitis, evidence for phlegmonous appendicitis remains limited. T...