Zhongshan Hospital

P1.059. Calcium-Channel Blocker Use and Survival After Neoadjuvant Therapy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Calcium-channel blockers (CCBs) are commonly prescribed for cardiovascular disease. Beyond hemodynamic effects, experimental studies suggest that CCBs may modulate tumor biology through interference...

P1.074. SNORD33-Driven 18S rRNA 2′-O-Methylation Licenses TNFSF9–4-1BB Signaling and Sensitizes ESCC to PD-1 Blockade

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant PD-1/PD-L1 based immunotherapy improve outcomes for resectable esophageal squamous cell carcinoma (ESCC), but patient outcome are heterogeneous and robust pretreatment blood biomarkers ar...

P1.058. Angiotensin System Inhibitors and Outcomes After Neoadjuvant Therapy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Renin angiotensin system signaling has been implicated in tumor growth, angiogenesis, immune modulation, and responses to cytotoxic and radiation-based therapies, yet clinical effects appear heteroge...

P1.073. The Evaluative Value of Quality of Life in Neoadjuvant Treatment for Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background While neoadjuvant therapy contribute to tumor downstaging and improves resectability rates, effective tools for predicting treatment response remain limited. This study investigated quality of life b...

OA03-RF01.07. Neoadjuvant Chemoimmunotherapy Versus Upfront Surgery for Clinical T2N0 Esophageal Squamous Cell Carcinoma: A Propensity Score-Matched Analysis

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The role of neoadjuvant chemoimmunotherapy (nICT) in clinical T2N0 (cT2N0) esophageal squamous cell carcinoma (ESCC) remains controversial. Current guidelines recommend upfront surgery for this popul...

P1.057. Early Recurrence After Neoadjuvant Therapy and Esophagectomy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Despite improved interventions with radical esophagectomy accompanied by perioperative systematic therapy, recurrence remains frequent in locally advanced esophageal squamous cell carcinoma (ESCC). A...

P1.245. Real-Time AI-Based Thoracic Duct Recognition During Thoracoscopic Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Thoracic duct injury during thoracoscopic esophagectomy may result in postoperative chylothorax, a serious complication associated with increased morbidity. However, intraoperative id...

Evaluationof 18F-FPPA as a PositronEmission Tomography Radioligand for Imaging CSF1R in LPS-Induced RatModel of Neuroinflammation

Abstract Noninvasive detection of microglia is crucial for monitoring their spatiotemporal dynamics and facilitating early medical intervention during the prodromal stages of these neuroinflammatory diseases. Colony-stimulating factor 1 receptor (CSF1R) is a promising imaging bio...

Metrnl Reduces Thrombosis and Acute Myocardial Injury Through Inhibition of Platelet Activation via CD36 Receptor Degradation

BACKGROUND: Metrnl (Meteorin-like) is a secreted protein that plays a pivotal role in regulating insulin sensitivity, angiogenesis, and atherosclerosis. The circulating Metrnl levels are mainly derived from the endothelium and associated with atherosclerosis and arterial thrombot...

Nanocatalytic anti-inflammatory therapy for alleviating rheumatoid lesions with endothelial cell-derived hydrosilicene

Severe inflammatory damage of soft tissues and progressive bone destruction are hallmark features of rheumatoid arthritis (RA), in which over-activated neutrophils and excessive neutrophil extracellular traps (NETs) play a pivotal role during the early stages of the disease. Conv...

Two-wave modified cardiometabolic index change patterns and incident edentulism in Chinese adults: a longitudinal study from CHARLS

Abstract Objectives Complete tooth loss is a late-stage oral health endpoint that may reflect cumulative oral, systemic, behavioral, and social risk processes. We examined whether two-wave patterns of the modified cardiometabolic index (MCMI) from 2011 to 2015 were associated wit...

MXene-Based Conductive Microneedle Patch Promotes Diabetic Wound Healing by Regulating Oxidative Stress and Immune Microenvironment

Abstract Excessive reactive oxygen species (ROS) generation and the release of inflammatory mediators create a pathological microenvironment in diabetic wounds, severely impairing the healing process. Coupling endogenous electric fields has shown great therapeutic potential for i...

The early dFLC level after autologous stem cell transplantation can predict the long-term prognosis of in patients with light chain amyloidosis

Abstract Recent studies show that the post-treatment difference between involved and uninvolved light chains (dFLC) predicts long-term prognosis in light chain (AL) amyloidosis. However, this issue remains underexplored in patients treated with autologous stem cell transplantatio...

Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis

Background: Humoral immunity targeting hepatitis B virus (HBV) surface antigen (HBsAg) is critical for viral clearance. However, the phenotypic, repertoire, and metabolic features of HBsAg-specific B cells in chronic hepatitis B (CHB) remain incompletely defined. Methods: HBsAg-s...

2-methylbutanal remodels arachidonic acid metabolism and antitumor immunity through ENO1 in colorectal cancer

Active aldehydes are increasingly recognized as bioactive metabolites, but their roles in tumor immune regulation remain poorly defined. In colorectal cancer (CRC), prostaglandin metabolism contributes to immune suppression, whereas its upstream metabolic regulators are incomplet...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

Benchmarking RNA-seq with the Quartet and MAQC reference materials to establish best practices for accurate alternative splicing analysis

Previous limited characterization of short-read RNA-seq (srRNA-seq) accuracy in alternative splicing (AS) analysis due to methodological diversity and lack of reference standards, has left unclear how to achieve optimal performance—an issue increasingly critical with the rise of...

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Abstract Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, i...