Zhongshan Hospital

Intelligent Inverse Design of Meta‐Absorbers Based on Reversible Deep Learning

ABSTRACT Optical meta‐absorbers are artificially engineered materials capable of trapping light in a highly controllable manner, rendering them attractive for a wide range of applications. Artificial intelligence provides powerful tools for the efficient design of such complex st...

AP2M1 promotes TNBC progression by stabilizing EGFR through inhibition of lysosomal degradation

Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous malignancy, with 50–80% of cases exhibiting elevated EGFR expression. Dysregulated endocytic trafficking contributes to sustained receptor signaling and tumor progression, suggesting endocytosis as a potentia...

Protective effects of icariin in atherosclerotic cardiovascular disease: mechanistic basis, post-ischemic protection and translational limitations

CONTEXT: Icariin (ICA), a prenylated flavonol glycoside from Epimedii Folium, has been investigated in experimental models relevant to atherosclerosis, myocardial infarction, and ischemic tissue injury. OBJECTIVES: This review evaluates experimental evidence on ICA in atheroscler...

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) currently lacks effective targeted therapeutics, while interleukin‐22 (IL‐22) as a potential treatment approach faces challenges in the clinical translation due to off‐target risks associated with systemic delivery....

The efficacy and safety of endoscopic resection for multiple rectal neuroendocrine tumors: a retrospective cohort study from a tertiary center

Multiple rectal neuroendocrine tumors (MR-NETs) are rare. There is no consensus on their characteristics and treatment. We aimed to evaluate the efficacy and safety of endoscopic resection (ER) for MR-NETs. We performed a retrospective review of 24 patients with 57 rectal NETs wh...

Self-buoyant cell-spheroid culture programming multi-spheroid assembly

Tempo-spatially controlled culture and assembly of cellular spheroids are fundamental in engineering tissue-like assembloids for scalable application, yet remain a technical challenge. Here, we show self-buoyant culture of cell spheroids and programmable assembly of multi-spheroi...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Macrophage-derived MMP14 fosters immunosuppressive tumor microenvironment by regulating soluble semaphorin 4D

Abstract High expression of semaphorin 4D (SEMA4D) in tumor cells fosters an immunosuppressive tumor microenvironment (TME), yet the underlying tumor-macrophage crosstalk remains poorly understood. Here, we investigated this regulatory axis using in vitro co-cultures and SEMA4D g...

TRIM3 functions as a tumor suppressor and predicts prognosis in triple-negative breast cancer: a multi-omics study with clinical cohort validation

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and limited treatment options. Tripartite motif-containing protein 3 (TRIM3), an E3 ubiquitin ligase, has been implicated as a tumor suppressor in several cancers; however, its biologi...

Effect of Dyadic Care Types on Knowledge‐Attitude‐Practice Relationship in Coronary Heart Disease Caring Dyads: A Moderated Mediation Model

ABSTRACT This study aimed to validate the knowledge‐attitude‐practice (KAP) model in coronary heart disease (CHD) patients and their family caregivers, and examine the moderating role of dyadic care types. Data were collected from 281 patient‐caregiver dyads, and moderated mediat...

Protocol for rolling circle amplification-based nanopore sequencing of eccDNA from cell and plasma samples

Extrachromosomal circular DNAs (eccDNAs) can drive copy number variation and genomic rearrangements and act as mobile regulators of gene expression. Here, we detail a protocol for eccDNA identification from cell and plasma samples. We describe steps for sample preprocessing with...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.

BACKGROUND: Cisplatin-based chemotherapy serves as a fundamental approach in the treatment of cervical cancer; however, its effectiveness is often hindered by the development of drug resistance, which presents a significant obstacle in clinical practice. METHODS: studies were car...

Coronary CT Angiography‐Derived Plaque and Hemodynamic Characteristics for In‐Stent Restenosis: A Self‐Controlled Study

ABSTRACT Background In‐stent restenosis (ISR) after percutaneous coronary interventions (PCI) remains a significant challenge. Aims This study aimed to investigate the predictive ability of coronary CT angiography (CTA) derived plaque and hemodynamic characteristics for ISR. Meth...

A positive feedback loop between HNRNPF and GRHL2 drives NEK8-mediated prostate cancer progression

Prostate cancer (PCa) remains a major cause of cancer-related mortality in men, especially in advanced stages. The role of Heterogeneous Nuclear Ribonucleoprotein F (HNRNPF) in PCa progression is poorly defined. The function and mechanism of HNRNPF were investigated using in vitr...

Plasma multi-omics signatures of the EAT-Lancet diet and associations with health outcomes

The EAT-Lancet diet aims to optimize human health and environmental sustainability, but the biological changes associated with this dietary pattern remain incompletely characterized. We aimed to identify plasma proteomic and metabolomic signatures associated with adherence to the...

Effects of Nominal Duty Cycle and Delayed Energization on the Reciprocating Friction and Wear Performance of GCr15 Bearing Steel

Under intermittent source-side excitation, electric-drive systems can maintain mechanical operation, so nominal energization parameters do not directly represent the interfacial electrical state. GCr15 ball-on-disk tests compared dry and polyalphaolefin (PAO 40)-lubricated condit...

Integrated postmortem brain transcriptomics identifies a five-gene Alzheimer’s disease-associated signature with a reproducible whole-blood CEBPB correlate

Transcriptomic profiling provides a systems-level view of Alzheimer’s disease (AD), capturing coordinated neuronal, glial, vascular, and immune-related changes. Yet the same breadth that makes transcriptomics informative also complicates interpretation because technical heterogen...

Coronary plaque phenotypes, inflammation and cardiovascular prognosis in metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) correlates with cardiovascular events. We sought to assess the association of coronary computed tomographic angiography (CCTA)-detected high-risk plaque characteristics (HRPC) and coronary inflammation with MASLD an...