Zhejiang University

Silicon-Based Highly c -Axis-OrientedStrontium Barium Niobate Films with Large Pockels Coefficients

Abstract To develop a new generation of high-performance silicon-based electro-optic modulators, it is necessary to find an electro-optic crystal with a simple fabrication process, stable chemical properties, and large Pockels coefficients, such as strontium barium niobate (SrxBa...

Wintertime organic carbon export provides a potential food source for zooplankton in the High Arctic

Abstract Pulsed particulate organic carbon export plays a vital role in sustaining Arctic marine ecosystems and the biological pump. Wintertime particulate organic carbon export in ice-covered Arctic waters is generally considered negligible due to light-limited local primary pro...

Draft Tube Wake Vortex Evolution and Suppression in a Pump as Turbine with Splitter Blades Based on a Modified Burgers Vortex Model

Owing to its efficient energy recovery capability, the pump as turbine (PAT) has attracted considerable attention and has been widely applied in micro hydropower systems. However, under off-design conditions, large-scale helical vortex ropes are readily induced in the draft tube,...

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

ABSTRACT Diabetic foot ulcers are a major complication of diabetes characterized by persistent inflammation and impaired tissue repair, in part driven by aberrant activation of the cGAS‐STING innate immune pathway. Precision immunomodulation in the protease‐rich wound microenviro...

Isolation, Characterization and Reverse Genetic System Establishment of a Highly Virulent PEDV Strain

Porcine epidemic diarrhea virus (PEDV) G2c variants have recently emerged, posing significant challenges to swine health management. As a major coronavirus affecting the swine industry, PEDV exhibits extensive genetic variability, which has greatly complicated disease control. Cu...

Shaking Table Test on Response of Prestressed Concrete Hybrid-Reinforced Solid Square Piles in Soft Versus Stiff Clay

Prestressed concrete hybrid-reinforced solid square (PCHSS) piles combine strands and rebars for improved ductility. This study presents large-scale shaking table tests (1:2 scale) on PCHSS pile–superstructure systems embedded in soft and stiff clay, subjected to four ground moti...

Observed CTIT onset timing is associated with platelet surveillance schedules in a real-world cohort

Chemotherapy-induced thrombocytopenia (CTIT) is detected through platelet testing, so routine-care estimates of onset and recovery may depend on surveillance schedules. We characterized within-cycle timing and assessed whether apparent differences among drug categories persisted...

Narrowband Hydrocarbon Emitters Enabled by Stereo‐Locked Through‐Space Interactions

ABSTRACT High‐purity emitters with a narrowband emission are a critical requirement for next‐generation displays and lighting, yet it remains a formidable challenge for purely organic materials, particularly in the pure‐violet region. Herein, a general molecular design strategy b...

An Adaptive In SituBiointerfacial Armoring Platformfor Long-Term Gut Microbiota Modulation

Abstract Despite the immense potential against diverse chronic inflammatory and metabolic disorders, the clinical translation of microbial therapies is largely thwarted by the delivery challenges of live biotherapeutics. Probiotics often succumb to harsh gastrointestinal conditio...

Adaptive Lagrangian Penalty-Enhanced Proximal Policy Optimization for Flexible Job Shop Rescheduling with Worker Workload Constraints Under Concurrent Dynamic Disturbances

When flexible job shop scheduling faces concurrent disturbances such as machine failures and rush orders, worker-centric constraints emphasized under Industry 5.0 must also be satisfied. Existing deep reinforcement learning methods for the Dynamic Flexible Job Shop Scheduling Pro...

Narrowband Hydrocarbon Emitters Enabled by Stereo‐Locked Through‐Space Interactions

ABSTRACT High‐purity emitters with a narrowband emission are a critical requirement for next‐generation displays and lighting, yet it remains a formidable challenge for purely organic materials, particularly in the pure‐violet region. Herein, a general molecular design strategy b...

Airway administered artificial mitochondria-enriched nanovesicles for efficient and selective mitochondria transfer to intervene in pulmonary fibrosis

Mitochondrial transplantation is a promising therapeutic approach involving the transfer of exogenous mitochondria into diseased cells to restore impaired mitochondrial homeostasis. However, its clinical translation is severely limited by the lack of efficient methods for precise...

Large Herbivores as Overlooked Vectors of Fungal and Oomycete Pathogens

Dispersal mechanisms of phytopathogenic fungi and oomycetes are critical components of forest disease dynamics. While wind and water are well-studied pathways, the role of large forest herbivores as passive vectors remains significantly overlooked. This study quantifies and compa...

“Jun-Chen-Zuo-Shi” - the Chinese medical perspective on clinical oncology nutritional therapy

Abstract Cancer-associated malnutrition and cachexia are common, clinically consequential syndromes that compromise treatment tolerance, increase postoperative and therapy-related complications, diminish quality of life, and shorten survival. Nutritional therapy is therefore incr...

Deformation behavior of plastic-metal hybrid components for optical image stabilization: from injection molding to thermal processing

Abstract Micro-structured plastic-metal hybrid (MPMH) components fabricated by insert injection molding are widely used in miniaturized optical modules because of their structural integration and multifunctional performance. However, the multi-stage processes from injection moldi...

Stability‐Enhanced Therapeutic Artificial Cells Based on a Lipid–Polymer Integrated Architecture

ABSTRACT Current artificial cells often lack robustness in the face of the complex physiological milieu. Additionally, the strategies for mimicking natural cargo exchange mostly rely on biological techniques, which involve integrating native channel proteins or adopting intact na...

Drainage Performance Degradation of Stone Columns Caused by Fine-Particle Migration during Shaking in Centrifuge Model Test

Abstract Stone columns are widely used in mitigating liquefaction hazards by accelerating the dissipation of excess pore pressure. However, studies on shaking-induced fine-particle migration and clogging in stone columns remain scarce. In this study, a dynamic centrifuge model te...

Machine Learning-Guided Stress Atlases Reveal Co-Expression Rewiring and Divergent Cellular Deployment of Abiotic Stress Programs in Rice and Wheat

Abiotic stress limits cereal productivity, yet whether conserved stress-responsive genes retain similar transcriptional network organization and cellular deployment across cereal species remains unknown. Here, we developed a machine learning-guided comparative framework to integr...

Security in the Fine‐Tuning Lifecycle of Large Language Models: Threats, Defenses, Evaluation, and Future Directions

ABSTRACT Background Fine‐tuning has become a core mechanism for adapting pretrained Large Language Models (LLMs) to downstream tasks. However, the dependence of fine‐tuning on training data, parameter update mechanisms, and reusable components provides entry points for attackers....

Translational control by RPL22L1-specific ribosomes enhances DNA repair and chemoresistance

Ribosome heterogeneity has emerged as a regulatory layer in gene expression, yet its biological roles in cancers remain poorly characterized. Here, we identify RPL22L1, a paralog of the ribosomal protein RPL22, as a key modulator of DNA damage response (DDR) in colorectal cancer...