Zhejiang Chinese Medical University

The imaging features of neurovascular compression in hemifacial spasm patients

Neurovascular compression is considered the main cause of primary hemifacial spasm. However, it also occurs on the asymptomatic facial nerves in primary hemifacial spasm patients and in healthy controls. This study aimed to compare neurovascular compression features among the thr...

Candidate Spatial Niches Associated with Gastric Cancer Metastasis and Treatment Resistance: Functional Classification, Evidence Boundaries, and a Translational Framework

Gastric cancer metastasis and poor treatment responses are spatially heterogeneous; however, single-marker positivity, cellular enrichment, or simple colocalization alone is insufficient to establish a functionally meaningful spatial niche. Within this framework, “treatment resis...

Deep learning radiomics based on preoperative multiparametric MRI in predicting breast cancer recurrence risk

Breast cancer treatments are often tailored to recurrence risk to improve outcomes, but reliable risk stratification methods are lacking. To predict preoperative breast cancer recurrence risk through a tridimensional synergy model integrating breast MRI, radiomics, and deep learn...

Risk Factors for Poor Neurological Outcomes at Discharge in Tuberculous Meningitis: Disease Severity, Host Factors, and Drug Therapy

Introduction: This study investigated independent factors associated with neurological prognosis at discharge in patients with tuberculous meningitis (TBM) and evaluated the impact of intensified treatment regimens. Methods: A retrospective analysis was conducted in 518 TBM patie...

Effect of Sequential Electroacupuncture Combined With Augmented Reality Gait Training on Walking Function and Neuromuscular Control in Subacute Stroke

OBJECTIVE: To investigate the effects of sequential electroacupuncture (EA) combined with augmented reality (AR) gait training on walking function and neuromuscular control in patients with subacute stroke (onset 1-6 mo). DESIGN: A single-blind, randomized controlled trial alloca...

Luteolin alleviates myocardial fibrosis through the ERK1/2-GATA4 pathway by inhibiting oxidative stress and EndMT

Introduction Myocardial fibrosis is a common pathological feature of cardiovascular diseases and is closely associated with oxidative stress, apoptosis, extracellular matrix remodeling, and endothelial-to-mesenchymal transition (EndMT). Luteolin (Lut), a naturally occurring flavo...

Two-stage management of traumatic comminuted trapezium fracture with severe bone defect: a case report and literature review

Trapezium fractures are rare carpal injuries, and comminuted intra-articular patterns with severe bone loss are exceptionally uncommon and challenging, with no established consensus; patient-specific 3D printing may offer a reconstructive option. We report a 51-year-old man who s...

Lymphoma presenting as chronic nonproductive cough misdiagnosed as lung cancer recurrence: a case report

Chronic nonproductive cough is a common initial symptom prompting patients to seek medical attention. Its etiology is complex and broad, often posing diagnostic challenges in clinical practice. A woman with a history of resected double primary lung cancer experienced a persistent...

Clinical characteristics and prognosis of IgA nephropathy and comorbid diabetic kidney disease

AIMS: This study characterized clinical features, pathology, treatment, and prognosis of biopsy-confirmed coexisting IgA nephropathy (IgAN) and diabetic kidney disease (DKD). METHODS: = 80), matched on age, sex and baseline serum creatinine (sCr). Baseline clinical and pathologic...

Impact of dynamic blood glucose trajectories on mortality in critically ill non-traumatic intracranial hemorrhage patients: a retrospective cohort study

Dysglycemia is frequently observed in patients with non-traumatic intracranial hemorrhage (ICH) and has been linked to adverse clinical outcomes. However, the prognostic impact of longitudinal blood glucose trajectories in critically ill non-traumatic intracranial hemorrhage rema...

Thermogenic adipose tissue as a therapeutic target: from human heterogeneity to pharmacological translation

Thermogenic adipose tissue, including classical brown adipose tissue (BAT) and inducible beige adipocytes, has re-emerged as a promising therapeutic target in the obesity field. Because BAT can convert chemical energy into heat while also playing a role in regulating systemic glu...

Multi-omics analysis deciphers tenocytes chromatin states and epigenetic regulation of tendon homeostasis

Tenocytes are the principal effector cells responsible for tendon homeostasis and repair, whose functions are governed by precise transcription programs. However, the epigenetic basis underlying the establishment and maintenance of their cellular identity, particularly the genome...

Angelica keiskei extract inhibits LPS-induced activation of microglia and ameliorates acute cerebral ischemic injury in mice

Angelica keiskei (Miq.) Koidz. [Apiaceae] is a botanical drug with dual-purpose as food and medicine and its improvement in acute cerebral ischemic injury has not been studied. In the present study, we investigated the anti-neuroinflammatory and protective effects of the ethyl ac...

Clinical application of systematic prostate biopsy combined with contrast-enhanced ultrasound guided targeted biopsy in patients with PSA gray zone

Abstract Objective To investigate the clinical value of combining systematic prostate biopsy with contrast-enhanced ultrasound (CEUS)-guided targeted biopsy in patients with serum prostate-specific antigen (PSA) levels in the gray zone. Methods A total of 167 patients in the PSA...

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

ABSTRACT Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia among the elderly, characterized by a gradual decline in memory and cognitive function. The growing body of evidence highlighting the interaction between the...

SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

ABSTRACT This study developed an integrated strategy combining surface plasmon resonance (SPR) for real‐time biomolecular interaction analysis, ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF/MS) for compound profiling,...

pH responsive nanoplatforms for radiosensitization and radioprotection in cancer therapy

Radiotherapy remains a cornerstone of cancer treatment, but its efficacy is limited by tumor hypoxia, adaptive antioxidant defenses, and the resulting radioresistance. Tumor extracellular acidity, commonly reported within an approximate pH range of 6.5–7.1, contributes to invasio...

Quality and reliability of osteoporosis-related health information on short-video platforms: a multi-source cross-sectional study

Abstract Background Osteoporosis (OP) affects approximately 145.86 million people in China, imposing substantial disease and societal burden. Effective management requires evidence-based patient education. Short-video platforms dominate health communication, yet no study has syst...

Genomic predisposition is associated with the direction of sex chromosome evolution

Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 geckos, we found that gecko sex chromosomes originated independently from 16 ances...

Cryptotanshinone inhibits Staphylococcus aureus NdhC via uncompetitive inhibition: Collateral sensitivity in respiratory-deficient SCVs

Staphylococcus aureus small colony variants (SCVs) pose a clinical challenge due to antibiotic tolerance and recurrent infections. Targeting the bacterial respiratory chain offers a potential strategy to overcome SCV-mediated resistance. Here we show that cryptotanshinone (CT) se...