Institution
Zhejiang Chinese Medical University
Recent research
- Engineering & TechnologyOpen access
The electric vehicle would represent the latest technique where the key one batteries group is too big and heavy that may influence the car rotary-inertia make the car bigger force to drive. Another one will be the battery anti-coldness capacity in north area &winter knowing how...
- BiologyOpen access
The deubiquitinating enzyme USP42 promotes lung adenocarcinoma progression through PTGS2
The ubiquitin-specific peptidase 42 (USP42) is a cysteine-dependent deubiquitinase with pro-tumorigenic roles in several cancers. In lung adenocarcinoma (LUAD), elevated USP42 expression correlates with advanced stage and poor survival, mirroring the prognostic impact of prostagl...
- BiologyOpen access
ABSTRACT Burkholderia gladioli pathovar cocovenenans produces the potent mitochondrial toxin bongkrekic acid (BA), causing severe foodborne outbreaks. Conventional detection methods are constrained by prolonged turnaround times and the need for sophisticated instruments, limiting...
- Society & EconomicsOpen access
Whether neighborhood interaction is differently associated with initiation and cessation of social participation in early old age remains unclear. We analyzed 1,688 Japanese adults surveyed at ages 65 and 70. Initiation and cessation were examined separately using modified Poisso...
- BiologyOpen access
Genetically predicted circulating polyunsaturated fatty acids and Crohn’s disease susceptibility
Crohn disease (CD) remains an increasing global health burden. Omega-3 and omega-6 polyunsaturated fatty acids participate in lipid metabolism and inflammatory regulation, but previous observational and interventional studies have produced inconsistent findings. This study aimed...
- Health & MedicineOpen access
This study aimed to retrospectively evaluate clinical outcomes, recurrence, and complications associated with interposition and transposition techniques for the management of vertebrobasilar dolichoectasia (VBD) in patients with hemifacial spasm (HFS). We retrospectively reviewed...
- Health & MedicineOpen access
Phase 3 interim reports have expanded the evidence for therapies targeting a proliferation-inducing ligand (APRIL) alone or both B-cell activating factor (BAFF) and APRIL in IgA nephropathy (IgAN). We evaluated their effects relative to placebo on proteinuria, kidney function, ph...
- BiologyOpen access
Post-stroke shoulder pain can interfere with upper-limb rehabilitation and daily functioning. This single-center retrospective cohort study evaluated whether initiation of adjunctive transcranial direct current stimulation (tDCS) within 48 h after ultrasound-guided shoulder injec...
- Climate & EnvironmentOpen access
The Boosted Research of Activating the Chinese Three Provinces GDP Status on Sustainability I
An embodied artificial intelligence as an important robot product has felt concept and behavior based on the physical body through connecting with environmental communication so as to acquire information̖ understanding problem and make decision for the sake of realizing behavior...
- Society & EconomicsOpen access
The “intention-behavior gap” represents a core bottleneck in the failure of health behavior interventions, with traditional theories offering insufficient explanations for the dynamic mechanisms from intention formation to behavior maintenance. The Multi-Process Action Control (M...
- Health & MedicineOpen access
The TOX2/MT1F Axis Mediates Breast Cancer Cell Proliferation and Xenograft Growth
Background: Aberrant DNA methylation is a key epigenetic mechanism involved in breast cancer (BC) progression. Thymocyte selection-associated high mobility group box 2 (TOX2) has been reported to undergo hypermethylation in BC; however, its functional role and downstream regulato...
- BiologyOpen access
Impact of plant sex on endophytic microbial diversity and community assembly in dioecious species
ABSTRACT Dioecious plants show marked sexual dimorphism in morphology, physiology, defense, and life-history allocation, yet differences in endophytic microbiomes remain understudied. We compared endophytic bacterial and fungal communities between male and female individuals of f...
- Health & MedicineOpen access
Whipple’s disease is a rare systemic infection caused by Tropheryma whipplei ( T. whipplei ). Pulmonary involvement is uncommon and may mimic sarcoidosis, tuberculosis, or malignancy, delaying diagnosis. Pulmonary presentations may be atypical and nonspecific. We report the case...
- AI & ComputingOpen access
The cities’ GDP will compare different ones for seeing the variation among the similar ones know how they would improve that one through analyzing the local situation and its surround cities and meantime learn the priority and better ones’ experience from other excellent places a...
- Health & Medicine
ABSTRACT Pressure ulcer (PU) typically arises as a chronic cutaneous ulcer stemming from a complex interplay of factors. However, the underlying mechanisms of this condition remain unclear. The aim of this study was to identify inflammatory biomarkers in patients with PU. In this...
- Health & MedicineOpen access
Abstract Background Women are disproportionately affected by heart failure with preserved ejection fraction (HFpEF), particularly at older ages, but this epidemiological pattern does not establish sex-modified cardiomyocyte mechanisms. We evaluated whether current evidence suppor...
- Engineering & Technology
Abstract Expanding single-tube multiplexing beyond the number of fluorescence channels on a real-time PCR instrument is a persistent challenge for point-of-care testing (POCT). Here, we break this barrier by leveraging melting temperature (Tm) as an extra information dimension. B...
- Health & MedicineOpen access
Androgen receptor pathway inhibitors (ARPIs) are widely used across multiple prostate cancer disease states, but fracture outcomes are inconsistently reported across randomized trials. We aimed to quantify the risks of all-grade and grade ≥ 3 trial-reported fracture-related adver...
- Health & MedicineOpen access
BACKGROUND: Postoperative gastrointestinal dysfunction (POGD) commonly presents with nausea, vomiting, abdominal distension, delayed flatus or stool, and prolonged intolerance to oral intake. It can cause postoperative pain, delayed gastrointestinal motility, or intestinal obstru...
- BiologyOpen access
Learning chemical-induced gene expression perturbations with WAVE
Chemical-induced transcriptional profiles facilitate systematic characterization of compound-driven perturbations, offering critical insights into mechanisms of action, especially for compounds with poorly defined molecular targets. However, experimentally profiling gene expressi...